Search Results - "PHAROAH, Pdp"

Explaining Disparities in Ovarian Cancer Incidence Rates between Women of African and European Ancestry: The Role of Genetic Factors by Mullins, M, Mukherjee, B, Wu, AH, Pike, M, Pharoah, PDP, Berchuck, A, Pearce, CL

“…Abstract Non-Hispanic White (NHW) women are at higher risk of ovarian cancer than African-American (AA) women. Approximately 30% of the difference in…”
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A multi-center study to evaluate the impact of germline BRCA1 and BRCA2 mutations on ovarian cancer survival by Bolton, KL, Chenevix-Trench, G, Goh, C, Sadetzki, S, Ramus, SJ, Gayther, SA, Chanock, SJ, Antoniou, AC, Pharoah, PDP

“…Doc number: A27…”
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A Mendelian randomization analysis of circulating lipid traits and breast cancer risk by Beeghly-Fadiel, Alicia, Khankari, Nikhil K, Delahanty, Ryan J, Shu, Xiao-Ou, Lu, Yingchang, Schmidt, Marjanka K, Bolla, Manjeet K, Michailidou, Kyriaki, Wang, Qin, Dennis, Joe, Yannoukakos, Drakoulis, Dunning, Alison M, Pharoah, Paul D P, Chenevix-Trench, Georgia, Milne, Roger L, Hunter, David J, Per, Hall, Kraft, Peter, Simard, Jacques, Easton, Douglas F, Zheng, Wei

“…Abstract Background Conventional epidemiologic studies have evaluated associations between circulating lipid levels and breast cancer risk, but results have…”
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Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis by Rontogianni, Marina O., Bouras, Emmanouil, Aglago, Elom Kouassivi, Freisling, Heinz, Murphy, Neil, Cotterchio, Michelle, Hampe, Jochen, Lindblom, Annika, Pai, Rish K., Pharoah, Paul D. P., Phipps, Amanda I., van Duijnhoven, Franzel J. B., Visvanathan, Kala, van Guelpen, Bethany, Li, Christopher I., Brenner, Hermann, Pellatt, Andrew J., Ogino, Shuji, Gunter, Marc J., Peters, Ulrike, Christakoudi, Sofia, Tsilidis, Konstantinos K.

“…Background Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal…”
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Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics by Jia, Guochong, Ping, Jie, Shu, Xiang, Yang, Yaohua, Cai, Qiuyin, Kweon, Sun-Seog, Choi, Ji-Yeob, Kubo, Michiaki, Park, Sue K., Bolla, Manjeet K., Dennis, Joe, Wang, Qin, Guo, Xingyi, Li, Bingshan, Tao, Ran, Aronson, Kristan J., Chan, Tsun L., Gao, Yu-Tang, Hartman, Mikael, Ho, Weang Kee, Ito, Hidemi, Iwasaki, Motoki, Iwata, Hiroji, John, Esther M., Kasuga, Yoshio, Kim, Mi-Kyung, Kurian, Allison W., Kwong, Ava, Li, Jingmei, Lophatananon, Artitaya, Low, Siew-Kee, Mariapun, Shivaani, Matsuda, Koichi, Matsuo, Keitaro, Muir, Kenneth, Noh, Dong-Young, Park, Boyoung, Park, Min-Ho, Shen, Chen-Yang, Shin, Min-Ho, Spinelli, John J., Takahashi, Atsushi, Tseng, Chiuchen, Tsugane, Shoichiro, Wu, Anna H., Yamaji, Taiki, Zheng, Ying, Dunning, Alison M., Pharoah, Paul D.P., Teo, Soo-Hwang, Kang, Daehee, Easton, Douglas F., Simard, Jacques, Shu, Xiao-ou, Long, Jirong, Zheng, Wei

“…By combining data from 160,500 individuals with breast cancer and 226,196 controls of Asian and European ancestry, we conducted genome- and transcriptome-wide…”
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Validation of the online prediction tool PREDICT v. 2.0 in the Dutch breast cancer population by van Maaren, M.C., van Steenbeek, C.D., Pharoah, P.D.P., Witteveen, A., Sonke, G.S., Strobbe, L.J.A., Poortmans, P.M.P., Siesling, S.

“…PREDICT version 2.0 is increasingly used to estimate prognosis in breast cancer. This study aimed to validate this tool in specific prognostic subgroups in the…”
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PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2 by Wishart, G C, Bajdik, C D, Dicks, E, Provenzano, E, Schmidt, M K, Sherman, M, Greenberg, D C, Green, A R, Gelmon, K A, Kosma, V-M, Olson, J E, Beckmann, M W, Winqvist, R, Cross, S S, Severi, G, Huntsman, D, Pylkäs, K, Ellis, I, Nielsen, T O, Giles, G, Blomqvist, C, Fasching, P A, Couch, F J, Rakha, E, Foulkes, W D, Blows, F M, Bégin, L R, van't Veer, L J, Southey, M, Nevanlinna, H, Mannermaa, A, Cox, A, Cheang, M, Baglietto, L, Caldas, C, Garcia-Closas, M, Pharoah, P D P

“…Background: Predict ( www.predict.nhs.uk ) is an online, breast cancer prognostication and treatment benefit tool. The aim of this study was to incorporate the…”
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Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium by Kapoor, Pooja Middha, Lindström, Sara, Behrens, Sabine, Wang, Xiaoliang, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Dunning, Alison M, Pharoah, Paul D P, Schmidt, Marjanka K, Kraft, Peter, García-Closas, Montserrat, Easton, Douglas F, Milne, Roger L, Chang-Claude, Jenny

“…Abstract Background Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest…”
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Abstract P3-08-02: Validation of the online prediction tool PREDICT v. 2.0: A large population-based study in the Netherlands by van Maaren, MC, van Steekbeek, CD, Pharoah, PDP, Witteveen, A, Sonke, GS, Strobbe, LJA, Poortmans, PMP, Siesling, S

“…Abstract Background This study aimed to validate the online prediction tool PREDICT version 2.0 on a large population-based cohort in the Netherlands. Separate…”
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Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families by Pharoah, Paul D.P., Guilford, Parry, Caldas, Carlos, The International Gastric Cancer Linkage Consortium

“…Germline mutations in CDH1 are known to cause hereditary diffuse gastric cancer (HDGC). Breast and colorectal cancer have also been reported in…”
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Association studies for finding cancer-susceptibility genetic variants by Ponder, Bruce A. J, Pharoah, Paul D. P, Dunning, Alison M, Easton, Douglas F

“…Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of…”
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Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry by Wen, Wanqing, Shu, Xiao-Ou, Guo, Xingyi, Cai, Qiuyin, Long, Jirong, Bolla, Manjeet K, Michailidou, Kyriaki, Dennis, Joe, Wang, Qin, Gao, Yu-Tang, Zheng, Ying, Dunning, Alison M, García-Closas, Montserrat, Brennan, Paul, Chen, Shou-Tung, Choi, Ji-Yeob, Hartman, Mikael, Ito, Hidemi, Lophatananon, Artitaya, Matsuo, Keitaro, Miao, Hui, Muir, Kenneth, Sangrajrang, Suleeporn, Shen, Chen-Yang, Teo, Soo H, Tseng, Chiu-Chen, Wu, Anna H, Yip, Cheng Har, Simard, Jacques, Pharoah, Paul D P, Hall, Per, Kang, Daehee, Xiang, Yongbing, Easton, Douglas F, Zheng, Wei

“…Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in…”
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Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies by Antoniou, A., Pharoah, P.D.P., Narod, S., Risch, H.A., Eyfjord, J.E., Hopper, J.L., Loman, N., Olsson, H., Johannsson, O., Borg, Å., Pasini, B., Radice, P., Manoukian, S., Eccles, D.M., Tang, N., Olah, E., Anton-Culver, H., Warner, E., Lubinski, J., Gronwald, J., Gorski, B., Tulinius, H., Thorlacius, S., Eerola, H., Nevanlinna, H., Syrjäkoski, K., Kallioniemi, O.-P., Thompson, D., Evans, C., Peto, J., Lalloo, F., Evans, D.G., Easton, D.F.

“…Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on…”
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Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer by Wichert, Katharina, Hoppe, Reiner, Ickstadt, Katja, Behrens, Thomas, Winter, Stefan, Herold, Robert, Terschüren, Claudia, Lo, Wing-Yee, Guénel, Pascal, Truong, Thérèse, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Lush, Michael, Andrulis, Irene L., Brenner, Hermann, Chang-Claude, Jenny, Cox, Angela, Cross, Simon S., Czene, Kamila, Eriksson, Mikael, Figueroa, Jonine D., García-Closas, Montserrat, Goldberg, Mark S., Hamann, Ute, He, Wei, Holleczek, Bernd, Hopper, John L., Jakubowska, Anna, Ko, Yon-Dschun, Lubiński, Jan, Mulligan, Anna Marie, Obi, Nadia, Rhenius, Valerie, Shah, Mitul, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C., Zheng, Wei, Dunning, Alison M., Pharoah, Paul D. P., Hall, Per, Easton, Douglas F., Brüning, Thomas, Brauch, Hiltrud, Harth, Volker, Rabstein, Sylvia

“…Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We…”
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Polygenic susceptibility to breast cancer and implications for prevention by Pharoah, Paul D.P, Antoniou, Antonis, Bobrow, Martin, Zimmern, Ron L, Easton, Douglas F, Ponder, Bruce A.J

“…The knowledge of human genetic variation that will come from the human genome sequence makes feasible a polygenic approach to disease prevention, in which it…”
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A Transforming Growth Factor beta 1 Signal Peptide Variant Increases Secretion in Vitro and Is Associated with Increased Incidence of Invasive Breast Cancer by Dunning, A M, Ellis, P D, McBride, S, Kirschenlohr, H L, Healey, C S, Kemp, PR, Luben, R N, Chang-Claude, J, Mannermaa, A, Kataja, V, Pharoah, PDP, Easton, D F, Ponder, BAJ, Metcalfe, J C

“…There is evidence that transforming growth factor (TGF) beta acts as a suppressor of tumor initiation but also as a promoter of tumor progression when the…”
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The association between weight at birth and breast cancer risk revisited using Mendelian randomisation by Kar, Siddhartha P., Andrulis, Irene L., Brenner, Hermann, Burgess, Stephen, Chang-Claude, Jenny, Considine, Daniel, Dörk, Thilo, Evans, Dafydd Gareth R., Gago-Domínguez, Manuela, Giles, Graham G., Hartman, Mikael, Huo, Dezheng, Kaaks, Rudolf, Li, Jingmei, Lophatananon, Artitaya, Margolin, Sara, Milne, Roger L., Muir, Kenneth R., Olsson, Håkan, Punie, Kevin, Radice, Paolo, Simard, Jacques, Tamimi, Rulla M., Van Nieuwenhuysen, Els, Wendt, Camilla, Zheng, Wei, Pharoah, Paul D. P.

“…Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample…”
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Public health genomics and personalized prevention: lessons from the COGS project by Pashayan, N., Hall, A., Chowdhury, S., Dent, T., Pharoah, P. D. P., Burton, H.

“…Using the principles of public health genomics, we examined the opportunities and challenges of implementing personalized prevention programmes for cancer at…”
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Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases

“…Estimates of the contribution of BRCA1 and BRCA2 to breast cancer incidence in outbred populations have been based on studies that are either small or have…”
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A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes by Antoniou, A C, Pharoah, P D P, McMullan, G, Day, N E, Stratton, M R, Peto, J, Ponder, B J, Easton, D F

“…In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic counselling purposes, it is important to allow for the fact that other breast…”
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