Search Results - "PHANSTIEL, Otto"

An overview of polyamine metabolism in pancreatic ductal adenocarcinoma by Phanstiel, Otto

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. With current therapies only…”
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ATP13A3 facilitates polyamine transport in human pancreatic cancer cells by Sekhar, Vandana, Andl, Thomas, Phanstiel, Otto

“…The purpose of this study is to provide an increased understanding of the molecular mechanisms responsible for mammalian polyamine transport, a process that…”
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Synthesis and bioevaluation of substituted chalcones, coumaranones and other flavonoids as anti-HIV agents by Cole, Amy L., Hossain, Sandra, Cole, Alex M., Phanstiel, Otto

“…[Display omitted] A series of chalcone, flavone, coumaranone and other flavonoid compounds were screened for their anti HIV-1 activity in two cell culture…”
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Antibiotic Adjuvants: Make Antibiotics Great Again by Douafer, Hana, Andrieu, Véronique, Phanstiel, Otto, Brunel, Jean Michel

“…Multiple approaches have been developed to combat bacterial resistance. However, the combination of antibiotic resistance mechanisms by bacteria and the…”
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Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation by Arnoletti, Juan Pablo, Reza, Joseph, Rosales, Armando, Monreal, Alberto, Fanaian, Na'im, Whisner, Suzanne, Srivastava, Milan, Rivera-Otero, Julia, Yu, Gongxin, Phanstiel Iv, Otto, Altomare, Deborah A, Tran, Quang, Litherland, Sally A

“…The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of…”
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Genetic portrait of polyamine transporters in barley: insights in the regulation of leaf senescence by Stolarska, Ewelina, Tanwar, Umesh Kumar, Guan, Yufeng, Grabsztunowicz, Magda, Arasimowicz-Jelonek, Magdalena, Phanstiel, 4th, Otto, Sobieszczuk-Nowicka, Ewa

“…Nitrogen (N) is one of the most expensive nutrients to supply, therefore, improving the efficiency of N use is essential to reduce the cost of commercial…”
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Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers against Resistant Gram‐Negative Bacteria by Borselli, Diane, Blanchet, Marine, Bolla, Jean‐Michel, Muth, Aaron, Skruber, Kristen, Phanstiel, Otto, Brunel, Jean Michel

“…Dihydromotuporamine C and its derivatives were evaluated for their in vitro antimicrobial activities and antibiotic enhancement properties against…”
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Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment by Nakkina, Sai Preethi, Gitto, Sarah B, Pandey, Veethika, Parikh, Jignesh G, Geerts, Dirk, Maurer, Hans Carlo, Olive, Kenneth P, Phanstiel, 4th, Otto, Altomare, Deborah A

“…Pancreatic cancer is the fourth leading cause of cancer death. Existing therapies only moderately improve pancreatic ductal adenocarcinoma (PDAC) patient…”
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DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the Pancreatic Tumor Microenvironment by Nakkina, Sai Preethi, Gitto, Sarah B, Beardsley, Jordan M, Pandey, Veethika, Rohr, Michael W, Parikh, Jignesh G, Phanstiel, 4th, Otto, Altomare, Deborah A

“…Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor five-year survival rate of less than 10%. Immune suppression along with chemoresistance are…”
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Impact of Difluoromethylornithine and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae by Ayoola, Moses B, Shack, Leslie A, Phanstiel, 4th, Otto, Nanduri, Bindu

“…(Spn), a Gram-positive bacterium, poses a significant threat to human health, causing mild respiratory infections to severe invasive conditions. Despite the…”
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Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci by Ayoola, Moses B., Shack, Leslie A., Lee, Jung Hwa, Lim, Juhyeon, Eoh, Hyungjin, Swiatlo, Edwin, Phanstiel, Otto, Nanduri, Bindu

“…Polyamines are small cationic molecules that have been linked to various cellular processes including replication, translation, stress response and recently,…”
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The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes by Malpica-Nieves, Christian J., Rivera-Aponte, David E., Tejeda-Bayron, Flavia A., Mayor, Angel M., Phanstiel, Otto, Veh, Rüdiger W., Eaton, Misty J., Skatchkov, Serguei N.

“…Polyamines (PAs), such as spermidine (SPD) and spermine (SPM), are essential to promote cell growth, survival, proliferation, and longevity. In the adult…”
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Caenorhabditis elegans P₅B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference by Heinick, Alexander, Urban, Katja, Roth, Stefan, Spies, Danica, Nunes, Frank, Phanstiel, Otto IV, Liebau, Eva, Lüersen, Kai

“…Physiological polyamines are required in various biological processes. In the current study, we used norspermidine, a structural analog of the natural…”
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Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers by Massaro, Chelsea, Thomas, Jenna, Phanstiel Iv, Otto

“…Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer…”
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Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice by Alexander, Eric T, Fahey, Erin, Phanstiel, 4th, Otto, Gilmour, Susan K

“…GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor…”
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The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress by Sekhar, Vandana, Ikhlef, Houssine, Bunea, Alexandra, Nguyen, Viet S, Joo, Johan, Tantak, Mukund P, Moots, Holly, Phanstiel, 4th, Otto

“…Amino acid restriction induces cellular stress and cells often respond via the induction of autophagy. Autophagy or 'self-eating' enables the recycling of…”
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Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Antitumor Efficacy of PD-1 Blockade by Alexander, Eric T, Mariner, Kelsey, Donnelly, Julia, Phanstiel, 4th, Otto, Gilmour, Susan K

“…Despite unprecedented advances in the treatment of cancer through the use of immune checkpoint blockade (ICB), responses are not universal and alternative…”
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Putrescine Importer PlaP Contributes to Swarming Motility and Urothelial Cell Invasion in Proteus mirabilis by Kurihara(栗原新), Shin, Sakai(坂井友美), Yumi, Suzuki(鈴木秀之), Hideyuki, Muth, Aaron, Phanstiel, Otto, Rather, Philip N.

“…Previously, we reported that the speA gene, encoding arginine decarboxylase, is required for swarming in the urinary tract pathogen Proteus mirabilis. In…”
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Elucidating the Role of Chmp1 Overexpression in the Transport of Polyamines in Drosophila melanogaster by Stump, Coryn L, Casero, Jr, Robert A, Phanstiel, 4th, Otto, DiAngelo, Justin R, Nowotarski, Shannon L

“…Polyamines are small organic cations that are essential for many biological processes such as cell proliferation and cell cycle progression. While the…”
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Polyamine Transport Inhibitors: Design, Synthesis, and Combination Therapies with Difluoromethylornithine by Muth, Aaron, Madan, Meenu, Archer, Jennifer Julian, Ocampo, Nicolette, Rodriguez, Luis, Phanstiel, Otto

“…The development of polyamine transport inhibitors (PTIs), in combination with the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), provides a…”
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