Search Results - "PFEFFER, M"

Apoptosis: A Target for Anticancer Therapy by Pfeffer, Claire M, Singh, Amareshwar T K

“…Apoptosis, the cell's natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to…”
Get full text

Luminescent probes for the bioimaging of small anionic species in vitro and in vivo by Ashton, Trent D, Jolliffe, Katrina A, Pfeffer, Frederick M

“…The ability to spatiotemporally identify the formation of specific anionic species, or track changes in their concentration inside living systems, is of…”
Get more information

The Role of miR-21 in Cancer by Pfeffer, Susan R., Yang, Chuan He, Pfeffer, Lawrence M.

“…ABSTRACT Preclinical Research MicroRNAs (miRNAs) are small endogenous noncoding RNAs that suppress gene expression at the post‐transcriptional level. In the…”
Get full text

Colorimetric and fluorescent anion sensors: an overview of recent developments in the use of 1,8-naphthalimide-based chemosensors by Duke, Rebecca M, Veale, Emma B, Pfeffer, Frederick M, Kruger, Paul E, Gunnlaugsson, Thorfinnur

“…This critical review focuses on the development of anion sensors, being either fluorescent and/or colorimetric, based on the use of the 1,8-naphthalimide…”
Get more information

The role of nuclear factor κB in the interferon response by Pfeffer, Lawrence M

“…The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel…”
Get more information

The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo by Yang, Chuan He, Yue, Junming, Sims, Michelle, Pfeffer, Lawrence M

“…EF24 is a curcumin analog that has improved anticancer activity over curcumin, but its therapeutic potential and mechanism of action is unknown, which is…”
Get full text

Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells by Ganguly, Debolina, Sims, Michelle, Cai, Chun, Fan, Meiyun, Pfeffer, Lawrence M.

“…Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor that is refractory to existing therapeutic regimens, which reflects the presence…”
Get full text

Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition by Zhang, Ruitao, Zhao, Guannan, Shi, Huirong, Zhao, Xinxin, Wang, Baojin, Dong, Peixin, Watari, Hidemichi, Pfeffer, Lawrence M., Yue, Junming

“…The trace element zinc plays an indispensable role in human health and diseases including cancer due to its antioxidant properties. While zinc supplements have…”
Get full text

IFN Induces miR-21 through a Signal Transducer and Activator of Transcription 3-Dependent Pathway as a Suppressive Negative Feedback on IFN-Induced Apoptosis by CHUAN HE YANG, JUNMING YUE, MEIYUN FAN, PFEFFER, Lawrence M

“…The microRNA miR-21 is overexpressed in many human cancers, wherein accumulating evidence indicates that it functions as an oncogene. Here, we report that the…”
Get full text

Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer by Niu, J, Xue, A, Chi, Y, Xue, J, Wang, W, Zhao, Z, Fan, M, Yang, C H, Shao, Z-M, Pfeffer, L M, Wu, J, Wu, Z-H

“…Acquired therapeutic resistance is the major drawback to effective systemic therapies for cancers. Aggressive triple-negative breast cancers (TNBC) develop…”
Get full text

Stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreatic cancer: A multi-center, open-label phase 2 study by Chuong, Michael D., Lee, Percy, Low, Daniel A., Kim, Joshua, Mittauer, Kathryn E., Bassetti, Michael F., Glide-Hurst, Carri K., Raldow, Ann C., Yang, Yingli, Portelance, Lorraine, Padgett, Kyle R., Zaki, Bassem, Zhang, Rongxiao, Kim, Hyun, Henke, Lauren E., Price, Alex T., Mancias, Joseph D., Williams, Christopher L., Ng, John, Pennell, Ryan, Raphael Pfeffer, M., Levin, Daphne, Mueller, Adam C., Mooney, Karen E., Kelly, Patrick, Shah, Amish P., Boldrini, Luca, Placidi, Lorenzo, Fuss, Martin, Jitendra Parikh, Parag

“…•This is the first prospective study of ablative 5-fraction stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) for borderline resectable…”
Get full text

A Multi-Institutional Phase 2 Trial of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer by Parikh, Parag Jitendra, Lee, Percy, Low, Daniel A., Kim, Joshua, Mittauer, Kathryn E., Bassetti, Michael F., Glide-Hurst, Carri K., Raldow, Ann C., Yang, Yingli, Portelance, Lorraine, Padgett, Kyle R., Zaki, Bassem, Zhang, Rongxiao, Kim, Hyun, Henke, Lauren E., Price, Alex T., Mancias, Joseph D., Williams, Christopher L., Ng, John, Pennell, Ryan, Pfeffer, M. Raphael, Levin, Daphne, Mueller, Adam C., Mooney, Karen E., Kelly, Patrick, Shah, Amish P., Boldrini, Luca, Placidi, Lorenzo, Fuss, Martin, Chuong, Michael D.

“…Magnetic resonance (MR) image guidance may facilitate safe ultrahypofractionated radiation dose escalation for inoperable pancreatic ductal adenocarcinoma. We…”
Get full text

Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates by Li, Kui, Li, Nan L., Wei, Dahai, Pfeffer, Susan R., Fan, Meiyun, Pfeffer, Lawrence M.

“…Chemokines and inflammatory cytokines are key regulators of immunity and inflammation during viral infections. Hepatitis C virus (HCV) is a hepatotropic RNA…”
Get full text

MicroRNA miR-21 Regulates the Metastatic Behavior of B16 Melanoma Cells by Yang, Chuan He, Yue, Junming, Pfeffer, Susan R., Handorf, Charles R., Pfeffer, Lawrence M.

“…MicroRNA-21 (miR-21) is overexpressed in many human tumors and has been linked to various cellular processes altered in cancer. miR-21 is also up-regulated by…”
Get full text

Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial by Connolly, S, Pogue, J, Hart, R, Pfeffer, M, Hohnloser, S, Chrolavicius, S, Yusuf, S

“…Oral anticoagulation therapy reduces risk of vascular events in patients with atrial fibrillation. However, long-term monitoring is necessary and many patients…”
Get full text

The Oncogenic MicroRNA-21 Inhibits the Tumor Suppressive Activity of FBXO11 to Promote Tumorigenesis by Yang, Chuan He, Pfeffer, Susan R., Sims, Michelle, Yue, Junming, Wang, Yinan, Linga, Vijay G., Paulus, Elena, Davidoff, Andrew M., Pfeffer, Lawrence M.

“…The microRNA miR-21 is overexpressed in most human cancers and accumulating evidence indicates that it functions as an oncogene. Since miRNAs suppress the…”
Get full text

Editorial: Radiation therapy using MRI-LINAC - the right way to start: a guide for physicians and physicists, volume II by Pfeffer, Raphael M, Oyzar, Enis, David, Merav A Ben

Get full text

The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis by Chen, Hongfeng, Fan, Meiyun, Pfeffer, Lawrence M, Laribee, R Nicholas

“…Epigenetic changes in chromatin through histone post-translational modifications are essential for altering gene transcription in response to environmental…”
Get full text

miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway by Wang, Baojin, Li, Xia, Zhao, Guannan, Yan, Huan, Dong, Peixin, Watari, Hidemichi, Sims, Michelle, Li, Wei, Pfeffer, Lawrence M, Guo, Yuqi, Yue, Junming

“…We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting…”
Get full text

Survival time of Leptospira kirschneri serovar Grippotyphosa under different environmental conditions by Nau, L. H, Obiegala, A, Król, N, Mayer-Scholl, A, Pfeffer, M

“…Leptospirosis is a re-emerging zoonotic disease of high medical importance that affects humans worldwide. Humans or animals acquire an infection with…”
Get full text