Search Results - "PFÖHLER, Claudia"

Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence by Maurer, Marcus, Metz, Martin, Brehler, Randolf, Hillen, Uwe, Jakob, Thilo, Mahler, Vera, Pföhler, Claudia, Staubach, Petra, Treudler, Regina, Wedi, Bettina, Magerl, Markus

“…Omalizumab, a recombinant anti-IgE antibody, effectively treats chronic spontaneous urticaria. Evidence is lacking in patients with chronic inducible…”
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Clinical Models to Define Response and Survival With Anti-PD-1 Antibodies Alone or Combined With Ipilimumab in Metastatic Melanoma by Pires da Silva, Inês, Ahmed, Tasnia, McQuade, Jennifer L, Nebhan, Caroline A, Park, John J, Versluis, Judith M, Serra-Bellver, Patricio, Khan, Yasir, Slattery, Tim, Oberoi, Honey K, Ugurel, Selma, Haydu, Lauren E, Herbst, Rudolf, Utikal, Jochen, Pföhler, Claudia, Terheyden, Patrick, Weichenthal, Michael, Gutzmer, Ralf, Mohr, Peter, Rai, Rajat, Smith, Jessica L, Scolyer, Richard A, Arance, Ana M, Pickering, Lisa, Larkin, James, Lorigan, Paul, Blank, Christian U, Schadendorf, Dirk, Davies, Michael A, Carlino, Matteo S, Johnson, Douglas B, Long, Georgina V, Lo, Serigne N, Menzies, Alexander M

“…Currently, there are no robust biomarkers that predict immunotherapy outcomes in metastatic melanoma. We sought to build multivariable predictive models for…”
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Shortened progression free and overall survival to immune-checkpoint inhibitors in BRAF-, RAS- and NF1- (“Triple”) wild type melanomas by Jansen, Philipp, Galetzka, Wolfgang, Lodde, Georg C., Standl, Fabian, Zaremba, Anne, Herbst, Rudolf, Terheyden, Patrick, Utikal, Jochen, Pföhler, Claudia, Ulrich, Jens, Kreuter, Alexander, Mohr, Peter, Gutzmer, Ralf, Meier, Friedegund, Dippel, Edgar, Weichenthal, Michael, Placke, Jan-Malte, Landsberg, Jennifer, Möller, Inga, Sucker, Antje, Paschen, Annette, Hadaschik, Eva, Zimmer, Lisa, Livingstone, Elisabeth, Schadendorf, Dirk, Ugurel, Selma, Stang, Andreas, Griewank, Klaus G.

“…Melanomas lacking mutations in BRAF, NRAS and NF1 are frequently referred to as “triple wild-type” (tWT) melanomas. They constitute 5–10 % of all melanomas and…”
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Lipase elevation and type 1 diabetes mellitus related to immune checkpoint inhibitor therapy – A multicentre study of 90 patients from the German Dermatooncology Group by Grimmelmann, Imke, Momma, Michael, Zimmer, Lisa, Hassel, Jessica C., Heinzerling, Lucie, Pföhler, Claudia, Loquai, Carmen, Ruini, Cristel, Utikal, Jochen, Thoms, Kai-Martin, Kähler, Katharina C., Eigentler, Thomas, Herbst, Rudolf A., Meier, Friedegund, Debus, Dirk, Berking, Carola, Kochanek, Corinna, Ugurel, Selma, Gutzmer, Ralf

“…Immune checkpoint inhibition (ICI) triggers immune-related adverse events (irAEs). The relevance of lipase elevation remains unclear. Skin cancer patients with…”
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Merkel Cell Polyomavirus Status Is Not Associated with Clinical Course of Merkel Cell Carcinoma by Schrama, David, Peitsch, Wiebke K., Zapatka, Marc, Kneitz, Hermann, Houben, Roland, Eib, Steffi, Haferkamp, Sebastian, Moore, Patrick S., Shuda, Masahiro, Thompson, John F., Trefzer, Uwe, Pföhler, Claudia, Scolyer, Richard A., Becker, Jürgen C.

“…The majority of Merkel cell carcinomas (MCCs) are associated with the recently identified Merkel cell polyomavirus (MCV). However, as it is still unclear to…”
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TERT promoter mutations are associated with longer progression-free and overall survival in patients with BRAF-mutant melanoma receiving BRAF and MEK inhibitor therapy by Thielmann, Carl M., Matull, Johanna, Zaremba, Anne, Murali, Rajmohan, Chorti, Eleftheria, Lodde, Georg, Jansen, Philipp, Herbst, Rudolf, Terheyden, Patrick, Utikal, Jochen, Pföhler, Claudia, Ulrich, Jens, Kreuter, Alexander, Mohr, Peter, Gutzmer, Ralf, Meier, Friedegund, Dippel, Edgar, Weichenthal, Michael, Kretz, Julia, Möller, Inga, Sucker, Antje, Paschen, Annette, Livingstone, Elisabeth, Zimmer, Lisa, Hadaschik, Eva, Ugurel, Selma, Schadendorf, Dirk, Griewank, Klaus G.

“…Around 50% of cutaneous melanomas harbour therapeutically targetable BRAF V600 mutations. Reliable clinical biomarkers predicting duration of response to…”
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Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations by Cosgarea, Ioana, Ugurel, Selma, Sucker, Antje, Livingstone, Elisabeth, Zimmer, Lisa, Ziemer, Mirjana, Utikal, Jochen, Mohr, Peter, Pfeiffer, Christiane, Pföhler, Claudia, Hillen, Uwe, Horn, Susanne, Schadendorf, Dirk, Griewank, Klaus G, Roesch, Alexander

“…Mucosal melanoma represents ~1% of all melanomas, frequently having a poor prognosis due to diagnosis at a late stage of disease. Mucosal melanoma differs from…”
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Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study by Heppt, Markus V., Amaral, Teresa, Kähler, Katharina C., Heinzerling, Lucie, Hassel, Jessica C., Meissner, Markus, Kreuzberg, Nicole, Loquai, Carmen, Reinhardt, Lydia, Utikal, Jochen, Dabrowski, Evelyn, Gesierich, Anja, Pföhler, Claudia, Terheyden, Patrick, Thoms, Kai-Martin, Zimmer, Lisa, Eigentler, Thomas K., Kirchberger, Michael C., Stege, Henner M., Meier, Friedegund, Schlaak, Max, Berking, Carola

“…BackgroundUveal melanoma (UM) is highly refractory to treatment with dismal prognosis in advanced stages. The value of the combined checkpoint blockade with…”
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Low Vitamin D Status Predicts Poor Clinical Outcome in Advanced Melanoma Treated With Immune Checkpoint or BRAF/MEK Inhibitors: A Prospective Non-Interventional Side-by-Side Analysis by Reichrath, Jörg, Biersack, Florian, Wagenpfeil, Stefan, Schöpe, Jakob, Pföhler, Claudia, Saternus, Roman, Vogt, Thomas

“…In melanoma and other malignancies, low vitamin D status is associated with increased risk and poor prognosis. However, there are limited data of the impact of…”
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PD-L1 status does not predict the outcome of BRAF inhibitor therapy in metastatic melanoma by Schaper-Gerhardt, Katrin, Okoye, Steven, Herbst, Rudolf, Ulrich, Jens, Terheyden, Patrick, Pföhler, Claudia, Utikal, Jochen S., Kreuter, Alexander, Mohr, Peter, Dippel, Edgar, Satzger, Imke, Sucker, Antje, Schadendorf, Dirk, Ugurel, Selma, Gutzmer, Ralf

“…Targeted therapies with BRAF plus MEK inhibitors (BRAFi; MEKi) represent the major treatment strategy for patients with BRAF-mutated metastatic melanoma (MM)…”
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Anaphylaxis in Elderly Patients-Data From the European Anaphylaxis Registry by Aurich, Stefanie, Dölle-Bierke, Sabine, Francuzik, Wojciech, Bilo, Maria Beatrice, Christoff, George, Fernandez-Rivas, Montserrat, Hawranek, Thomas, Pföhler, Claudia, Poziomkowska-Gȩsicka, Iwona, Renaudin, Jean-Marie, Oppel, Eva, Scherer, Kathrin, Treudler, Regina, Worm, Margitta

“…Elicitors and symptoms of anaphylaxis are age dependent. However, little is known about typical features of anaphylaxis in patients aged 65 years or more. The…”
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Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register by Grabenhenrich, Linus B., Dölle, Sabine, Ruëff, Franziska, Renaudin, Jean-Marie, Scherer, Kathrin, Pföhler, Claudia, Treudler, Regina, Koehli, Alice, Mahler, Vera, Spindler, Thomas, Lange, Lars, Bilò, Maria Beatrice, Papadopoulos, Nikolaos G., Hourihane, Jonathan O.B., Lang, Roland, Fernández-Rivas, Montserrat, Christoff, George, Cichocka-Jarosz, Ewa, Worm, Margitta

“…Current guidelines recommend intramuscular administration of epinephrine as the first-line drug for the emergency treatment of severe allergic reactions…”
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In vitro Drug Sensitivity Predicts Response and Survival after Individualized Sensitivity-Directed Chemotherapy in Metastatic Melanoma: A Multicenter Phase II Trial of the Dermatologic Cooperative Oncology Group by Ugurel, Selma, Schadendorf, Dirk, Pföhler, Claudia, Neuber, Karsten, Thoelke, Adina, Ulrich, Jens, Hauschild, Axel, Spieth, Konstanze, Kaatz, Martin, Rittgen, Werner, Delorme, Stefan, Tilgen, Wolfgang, Reinhold, Uwe

“…Purpose: In vitro sensitivity assays are promising tools to predict the individual outcome of different chemotherapy regimens. However, a direct association…”
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Dermatological manifestations of tuberous sclerosis complex (TSC) by Ebrahimi‐Fakhari, Daniel, Meyer, Sascha, Vogt, Thomas, Pföhler, Claudia, Müller, Cornelia Sigrid Lissi

“…Summary Tuberous sclerosis complex (TSC) is a genetic multisystem disorder with prominent skin involvement that frequently occurs in early childhood…”
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Genetic Associations and Differential mRNA Expression Levels of Host Genes Suggest a Viral Trigger for Endemic Pemphigus Foliaceus by Hoch, Valéria Bumiller-Bini, Kohler, Ana Flávia, Augusto, Danillo G, Lobo-Alves, Sara Cristina, Malheiros, Danielle, Cipolla, Gabriel Adelman, Boldt, Angelica Beate Winter, Braun-Prado, Karin, Wittig, Michael, Franke, Andre, Pföhler, Claudia, Worm, Margitta, van Beek, Nina, Goebeler, Matthias, Sárdy, Miklós, Ibrahim, Saleh, Busch, Hauke, Schmidt, Enno, Hundt, Jennifer Elisabeth, Araujo-Souza, Patrícia Savio de, Petzl-Erler, Maria Luiza

“…The long search for the environmental trigger of the endemic pemphigus foliaceus (EPF, fogo selvagem) has not yet resulted in any tangible findings. Here, we…”
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Effectiveness, Safety and Utilization of Vismodegib for Locally Advanced Basal Cell Carcinoma Under Real-world Conditions: Non-interventional Cohort Study JONAS by Kaatz, Martin, Mohr, Peter, Livingstone, Elisabeth, Weichenthal, Michael, Kreuter, Alexander, Pföhler, Claudia, Leiter, Ulrike, Ulrich, Jens, Utikal, Jochen Sven, Gutzmer, Ralf, Herbst, Rudolf, Schadendorf, Dirk

“…Most patients with advanced basal cell carcinomas (BCCs) may not benefit sufficiently from standard treatment comprising surgery and radiation. Vismodegib, an…”
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Clinical and genetic characteristics of BAP1 -mutated non-uveal and uveal melanoma by Matull, Johanna, Placke, Jan-Malte, Lodde, Georg, Zaremba, Anne, Utikal, Jochen, Terheyden, Patrick, Pföhler, Claudia, Herbst, Rudolf, Kreuter, Alexander, Welzel, Julia, Kretz, Julia, Möller, Inga, Sucker, Antje, Paschen, Annette, Livingstone, Elisabeth, Zimmer, Lisa, Hadaschik, Eva, Ugurel, Selma, Schadendorf, Dirk, Thielmann, Carl Maximilian, Griewank, Klaus Georg

“…Screening for gene mutations has become routine clinical practice across numerous tumor entities, including melanoma. gene mutations have been identified in…”
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Food-Induced Anaphylaxis: Data From the European Anaphylaxis Registry by Dölle-Bierke, Sabine, Höfer, Veronika, Francuzik, Wojciech, Näher, Anatol-Fiete, Bilo, Maria Beatrice, Cichocka-Jarosz, Ewa, Lopes de Oliveira, Lucila C., Fernandez-Rivas, Montserrat, García, Blanca E., Hartmann, Karin, Jappe, Uta, Köhli, Alice, Lange, Lars, Maris, Ioana, Mustakov, Tihomir Bogdanov, Nemat, Katja, Ott, Hagen, Papadopoulos, Nikolaos G., Pföhler, Claudia, Ruëff, Franziska, Sabouraud-Leclerc, Dominique, Spindler, Thomas, Stock, Philippe, Treudler, Regina, Vogelberg, Christian, Wagner, Nicola, Worm, Margitta

“…Food is one of the most common elicitors of anaphylaxis, with an increasing incidence over recent years. To characterize elicitor-specific phenotypes and…”
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Genetic association and differential expression of HLA Complex Group lncRNAs in pemphigus by Salviano-Silva, Amanda, Becker, Mareike, Augusto, Danillo G., Busch, Hauke, Adelman Cipolla, Gabriel, Farias, Ticiana D.-J., Bumiller-Bini, Valéria, Calonga-Solís, Verónica, Munz, Matthias, Franke, Andre, Wittig, Michael, Camargo, Carolina M., Goebeler, Matthias, Hundt, Jennifer Elisabeth, Günther, Claudia, Gläser, Regine, Hadaschik, Eva, Pföhler, Claudia, Sárdy, Miklós, Van Beek, Nina, Worm, Margitta, Zillikens, Detlef, Boldt, Angelica B.W., Schmidt, Enno, Petzl-Erler, Maria Luiza, Ibrahim, Saleh, Malheiros, Danielle

“…Pemphigus is a group of bullous diseases characterized by acantholysis and skin blisters. As for other autoimmune diseases, the strongest genetic associations…”
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Adjuvant Therapy of High-Risk (Stages IIC-IV) Malignant Melanoma in the Post Interferon-Alpha Era: A Systematic Review and Meta-Analysis by Christofyllakis, Konstantinos, Pföhler, Claudia, Bewarder, Moritz, Müller, Cornelia S L, Thurner, Lorenz, Rixecker, Torben, Vogt, Thomas, Stilgenbauer, Stephan, Yordanova, Krista, Kaddu-Mulindwa, Dominic

“…Multiple agents are approved in the adjuvant setting of completely resected high-risk (stages IIC-IV) malignant melanoma. Subgroups may benefit differently…”
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