Search Results - "PEYSER, Patricia"

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology by Chen, Vincent L., Du, Xiaomeng, Chen, Yanhua, Kuppa, Annapurna, Handelman, Samuel K., Vohnoutka, Rishel B., Peyser, Patricia A., Palmer, Nicholette D., Bielak, Lawrence F., Halligan, Brian, Speliotes, Elizabeth K.

“…Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of…”
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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations by Kowalski, Madeline H, Qian, Huijun, Hou, Ziyi, Rosen, Jonathan D, Tapia, Amanda L, Shan, Yue, Jain, Deepti, Argos, Maria, Arnett, Donna K, Avery, Christy, Barnes, Kathleen C, Becker, Lewis C, Bien, Stephanie A, Bis, Joshua C, Blangero, John, Boerwinkle, Eric, Bowden, Donald W, Buyske, Steve, Cai, Jianwen, Cho, Michael H, Choi, Seung Hoan, Choquet, Hélène, Cupples, L Adrienne, Cushman, Mary, Daya, Michelle, de Vries, Paul S, Ellinor, Patrick T, Faraday, Nauder, Fornage, Myriam, Gabriel, Stacey, Ganesh, Santhi K, Graff, Misa, Gupta, Namrata, He, Jiang, Heckbert, Susan R, Hidalgo, Bertha, Hodonsky, Chani J, Irvin, Marguerite R, Johnson, Andrew D, Jorgenson, Eric, Kaplan, Robert, Kardia, Sharon L R, Kelly, Tanika N, Kooperberg, Charles, Lasky-Su, Jessica A, Loos, Ruth J F, Lubitz, Steven A, Mathias, Rasika A, McHugh, Caitlin P, Montgomery, Courtney, Moon, Jee-Young, Morrison, Alanna C, Palmer, Nicholette D, Pankratz, Nathan, Papanicolaou, George J, Peralta, Juan M, Peyser, Patricia A, Rich, Stephen S, Rotter, Jerome I, Silverman, Edwin K, Smith, Jennifer A, Smith, Nicholas L, Taylor, Kent D, Thornton, Timothy A, Tiwari, Hemant K, Tracy, Russell P, Wang, Tao, Weiss, Scott T, Weng, Lu-Chen, Wiggins, Kerri L, Wilson, James G, Yanek, Lisa R, Zöllner, Sebastian, North, Kari E, Auer, Paul L, Raffield, Laura M, Reiner, Alexander P, Li, Yun

“…Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of…”
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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps by Mahajan, Anubha, Taliun, Daniel, Thurner, Matthias, Robertson, Neil R., Torres, Jason M., Rayner, N. William, Payne, Anthony J., Steinthorsdottir, Valgerdur, Scott, Robert A., Grarup, Niels, Schmidt, Ellen M., Wuttke, Matthias, Sarnowski, Chloé, Mägi, Reedik, Nano, Jana, Gieger, Christian, Trompet, Stella, Lecoeur, Cécile, Preuss, Michael H., Prins, Bram Peter, Guo, Xiuqing, Bielak, Lawrence F., Below, Jennifer E., Bowden, Donald W., Kim, Young Jin, Petty, Lauren E., Sim, Xueling, Bennett, Amanda J., Bork-Jensen, Jette, Brummett, Chad M., Canouil, Mickaël, Ec kardt, Kai-Uwe, Fischer, Krista, Kardia, Sharon L. R., Kronenberg, Florian, Läll, Kristi, Luan, Jian’an, Ntalla, Ioanna, Nylander, Vibe, Schönherr, Sebastian, Schurmann, Claudia, Yengo, Loïc, Bottinger, Erwin P., Brandslund, Ivan, Christensen, Cramer, Dedoussis, George, Florez, Jose C., Ford, Ian, Franco, Oscar H., Frayling, Timothy M., Giedraitis, Vilmantas, Hackinger, Sophie, Hattersley, Andrew T., Herder, Christian, Ikram, M. Arfan, Jørgensen, Marit E., Jørgensen, Torben, Kriebel, Jennifer, Kuusisto, Johanna, Ligthart, Symen, Linneberg, Allan, Lyssenko, Valeriya, Mamakou, Vasiliki, Meitinger, Thomas, Morris, Andrew D., Nadkarni, Girish, Pankow, James S., Peters, Annette, Sattar, Naveed, Stančáková, Alena, Strauch, Konstantin, Taylor, Kent D., Thorand, Barbara, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tuomilehto, Jaakko, Witte, Daniel R., Dupuis, Josée, Peyser, Patricia A., Zeggini, Eleftheria, Froguel, Philippe, Ingelsson, Erik, Lind, Lars, Laakso, Markku, Collins, Francis S., Jukema, J. Wouter, Grallert, Harald, Metspalu, Andres, Köttgen, Anna, Abecasis, Goncalo R., Meigs, James B., Rotter, Jerome I., Marchini, Jonathan, Hansen, Torben, Langenberg, Claudia, Wareham, Nicholas J., Stefansson, Kari, Morris, Andrew P., Boehnke, Michael, McCarthy, Mark I.

“…We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density…”
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Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes by Ng, Maggie C Y, Shriner, Daniel, Chen, Brian H, Li, Jiang, Chen, Wei-Min, Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J, Yanek, Lisa R, Nalls, Michael A, Comeau, Mary E, Rasmussen-Torvik, Laura J, Jensen, Richard A, Evans, Daniel S, Sun, Yan V, An, Ping, Patel, Sanjay R, Lu, Yingchang, Long, Jirong, Armstrong, Loren L, Wagenknecht, Lynne, Yang, Lingyao, Snively, Beverly M, Palmer, Nicholette D, Mudgal, Poorva, Langefeld, Carl D, Keene, Keith L, Freedman, Barry I, Mychaleckyj, Josyf C, Nayak, Uma, Raffel, Leslie J, Goodarzi, Mark O, Chen, Y-D Ida, Taylor, Jr, Herman A, Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S, Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Chen, Guanjie, Mathias, Rasika A, Vaidya, Dhananjay, Singleton, Andrew B, Zonderman, Alan B, Igo, Jr, Robert P, Sedor, John R, Kabagambe, Edmond K, Siscovick, David S, McKnight, Barbara, Rice, Kenneth, Liu, Yongmei, Hsueh, Wen-Chi, Zhao, Wei, Bielak, Lawrence F, Kraja, Aldi, Province, Michael A, Bottinger, Erwin P, Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J, Lowe, William L, Pacheco, Jennifer A, Crawford, Dana C, Grundberg, Elin, Rich, Stephen S, Hayes, M Geoffrey, Shu, Xiao-Ou, Loos, Ruth J F, Borecki, Ingrid B, Peyser, Patricia A, Cummings, Steven R, Psaty, Bruce M, Fornage, Myriam, Iyengar, Sudha K, Evans, Michele K, Becker, Diane M, Kao, W H Linda, Wilson, James G, Rotter, Jerome I, Sale, Michèle M, Liu, Simin, Rotimi, Charles N, Bowden, Donald W

“…Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite…”
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Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease by Rule, Andrew D, Bailey, Kent R, Lieske, John C, Peyser, Patricia A, Turner, Stephen T

“…Chronic kidney disease risk factors may associate with the estimated glomerular filtration rate (eGFR) differently than with the measured GFR. To examine this,…”
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A Statistical Approach for Testing Cross-Phenotype Effects of Rare Variants by Broadaway, K. Alaine, Cutler, David J., Duncan, Richard, Moore, Jacob L., Ware, Erin B., Jhun, Min A., Bielak, Lawrence F., Zhao, Wei, Smith, Jennifer A., Peyser, Patricia A., Kardia, Sharon L.R., Ghosh, Debashis, Epstein, Michael P.

“…Increasing empirical evidence suggests that many genetic variants influence multiple distinct phenotypes. When cross-phenotype effects exist, multivariate…”
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Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection by Pollin, Toni I, Damcott, Coleen M, Shen, Haiqing, Ott, Sandra H, Shelton, John, Horenstein, Richard B, Post, Wendy, McLenithan, John C, Bielak, Lawrence F, Peyser, Patricia A, Mitchell, Braxton D, Miller, Michael, O'Connell, Jeffrey R, Shuldiner, Alan R

“…Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in coronary artery disease. Through a genome-wide association study,…”
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Author Correction: Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology by Chen, Vincent L., Du, Xiaomeng, Chen, Yanhua, Kuppa, Annapurna, Handelman, Samuel K., Vohnoutka, Rishel B., Peyser, Patricia A., Palmer, Nicholette D., Bielak, Lawrence F., Halligan, Brian, Speliotes, Elizabeth K.

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Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease by Chen, Yanhua, Du, Xiaomeng, Kuppa, Annapurna, Feitosa, Mary F., Bielak, Lawrence F., O’Connell, Jeffrey R., Musani, Solomon K., Guo, Xiuqing, Kahali, Bratati, Chen, Vincent L., Smith, Albert V., Ryan, Kathleen A., Eirksdottir, Gudny, Allison, Matthew A., Bowden, Donald W., Budoff, Matthew J., Carr, John Jeffrey, Chen, Yii-Der I., Taylor, Kent D., Oliveri, Antonino, Correa, Adolfo, Crudup, Breland F., Kardia, Sharon L. R., Mosley, Thomas H., Norris, Jill M., Terry, James G., Rotter, Jerome I., Wagenknecht, Lynne E., Halligan, Brian D., Young, Kendra A., Hokanson, John E., Washko, George R., Gudnason, Vilmundur, Province, Michael A., Peyser, Patricia A., Palmer, Nicholette D., Speliotes, Elizabeth K.

“…Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no effective treatments. We carried out a genome-wide association study…”
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Association between BMD and coronary artery calcification: an observational and Mendelian randomization study by Lu, Haojie, Lary, Christine W, Hodonsky, Chani J, Peyser, Patricia A, Bos, Daniel, van der Laan, Sander W, Miller, Clint L, Rivadeneira, Fernando, Kiel, Douglas P, Kavousi, Maryam, Medina-Gomez, Carolina

“…Observational studies have reported inconsistent associations between bone mineral density (BMD) and coronary artery calcification (CAC). We examined the…”
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Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease by Ward-Caviness, Cavin K, de Vries, Paul S, Wiggins, Kerri L, Huffman, Jennifer E, Yanek, Lisa R, Bielak, Lawrence F, Giulianini, Franco, Guo, Xiuqing, Kleber, Marcus E, Kacprowski, Tim, Groß, Stefan, Petersman, Astrid, Davey Smith, George, Hartwig, Fernando P, Bowden, Jack, Hemani, Gibran, Müller-Nuraysid, Martina, Strauch, Konstantin, Koenig, Wolfgang, Waldenberger, Melanie, Meitinger, Thomas, Pankratz, Nathan, Boerwinkle, Eric, Tang, Weihong, Fu, Yi-Ping, Johnson, Andrew D, Song, Ci, de Maat, Moniek P M, Uitterlinden, André G, Franco, Oscar H, Brody, Jennifer A, McKnight, Barbara, Chen, Yii-Der Ida, Psaty, Bruce M, Mathias, Rasika A, Becker, Diane M, Peyser, Patricia A, Smith, Jennifer A, Bielinski, Suzette J, Ridker, Paul M, Taylor, Kent D, Yao, Jie, Tracy, Russell, Delgado, Graciela, Trompet, Stella, Sattar, Naveed, Jukema, J Wouter, Becker, Lewis C, Kardia, Sharon L R, Rotter, Jerome I, März, Winfried, Dörr, Marcus, Chasman, Daniel I, Dehghan, Abbas, O'Donnell, Christopher J, Smith, Nicholas L, Peters, Annette, Morrison, Alanna C

“…Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary…”
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Associations Between Inflammation and Cognitive Function in African Americans and European Americans by Windham, B. Gwen, Simpson, Brittany N., Lirette, Seth, Bridges, John, Bielak, Lawrence, Peyser, Patricia A., Kullo, Iftikhar, Turner, Stephen, Griswold, Michael E., Mosley, Thomas H.

“…Objectives To examine associations between specific inflammatory biomarkers and cognitive function in African Americans (AAs) and European Americans (EAs) with…”
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Kidney Stones Associate with Increased Risk for Myocardial Infarction by RULE, Andrew D, ROGER, Veronique L, MELTON, L. Joseph, BERGSTRALH, Eric J, XUJIAN LI, PEYSER, Patricia A, KRAMBECK, Amy E, LIESKE, John C

“…Kidney stones are a risk factor for chronic kidney disease (CKD), which, in turn, is a risk factor for myocardial infarction (MI). The objective of this study…”
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Characterization of european ancestry nonalcoholic fatty liver disease‐associated variants in individuals of african and hispanic descent by Palmer, Nicholette D., Musani, Solomon K., Yerges‐Armstrong, Laura M., Feitosa, Mary F., Bielak, Lawrence F., Hernaez, Ruben, Kahali, Bratati, Carr, J. Jeffrey, Harris, Tamara B., Jhun, Min A., Kardia, Sharon L.R., Langefeld, Carl D., Mosley, Thomas H., Norris, Jill M., Smith, Albert V., Taylor, Herman A., Wagenknecht, Lynne E., Liu, Jiankang, Borecki, Ingrid B., Peyser, Patricia A., Speliotes, Elizabeth K.

“…Nonalcoholic fatty liver disease (NAFLD) is an obesity‐related condition affecting over 50% of individuals in some populations and is expected to become the…”
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Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization by Zheng, Jie, Wheeler, Eleanor, Pietzner, Maik, Andlauer, Till F M, Yau, Michelle S, Hartley, April E, Brumpton, Ben Michael, Rasheed, Humaira, Kemp, John P, Frysz, Monika, Robinson, Jamie, Reppe, Sjur, Prijatelj, Vid, Gautvik, Kaare M, Falk, Louise, Maerz, Winfried, Gergei, Ingrid, Peyser, Patricia A, Kavousi, Maryam, de Vries, Paul S, Miller, Clint L, Bos, Maxime, van der Laan, Sander W, Malhotra, Rajeev, Herrmann, Markus, Scharnagl, Hubert, Kleber, Marcus, Dedoussis, George, Zeggini, Eleftheria, Nethander, Maria, Ohlsson, Claes, Lorentzon, Mattias, Wareham, Nick, Langenberg, Claudia, Holmes, Michael V, Davey Smith, George, Tobias, Jonathan H

“…In this study, we aimed to establish the causal effects of lowering sclerostin, target of the antiosteoporosis drug romosozumab, on atherosclerosis and its…”
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Coronary Computed Tomography Angiography After Stress Testing by Chinnaiyan, Kavitha M., MD, Raff, Gilbert L., MD, Goraya, Tauqir, MD, PhD, Ananthasubramaniam, Karthikeyan, MD, Gallagher, Michael J., MD, Abidov, Aiden, MD, PhD, Boura, Judith A., MS, Share, David, MD, Peyser, Patricia A., PhD

“…Objectives This study was conducted to evaluate the correlation between stress test results and coronary computed tomography angiography (CCTA) findings and…”
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Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans by Ammous, Farah, Zhao, Wei, Ratliff, Scott M, Mosley, Thomas H, Bielak, Lawrence F, Zhou, Xiang, Peyser, Patricia A, Kardia, Sharon L R, Smith, Jennifer A

“…Cardiovascular disease (CVD) is the leading cause of mortality among US adults. African Americans have higher burden of CVD morbidity and mortality compared to…”
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Genome-wide association study of gene by smoking interactions in coronary artery calcification by Polfus, Linda M, Smith, Jennifer A, Shimmin, Lawrence C, Bielak, Lawrence F, Morrison, Alanna C, Kardia, Sharon L R, Peyser, Patricia A, Hixson, James E

“…Many GWAS have identified novel loci associated with common diseases, but have focused only on main effects of individual genetic variants rather than…”
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Genome-wide association of body fat distribution in African ancestry populations suggests new loci by Liu, Ching-Ti, Monda, Keri L, Taylor, Kira C, Lange, Leslie, Demerath, Ellen W, Palmas, Walter, Wojczynski, Mary K, Ellis, Jaclyn C, Vitolins, Mara Z, Liu, Simin, Papanicolaou, George J, Irvin, Marguerite R, Xue, Luting, Griffin, Paula J, Nalls, Michael A, Adeyemo, Adebowale, Liu, Jiankang, Li, Guo, Ruiz-Narvaez, Edward A, Chen, Wei-Min, Chen, Fang, Henderson, Brian E, Millikan, Robert C, Ambrosone, Christine B, Strom, Sara S, Guo, Xiuqing, Andrews, Jeanette S, Sun, Yan V, Mosley, Thomas H, Yanek, Lisa R, Shriner, Daniel, Haritunians, Talin, Rotter, Jerome I, Speliotes, Elizabeth K, Smith, Megan, Rosenberg, Lynn, Mychaleckyj, Josyf, Nayak, Uma, Spruill, Ida, Garvey, W Timothy, Pettaway, Curtis, Nyante, Sarah, Bandera, Elisa V, Britton, Angela F, Zonderman, Alan B, Rasmussen-Torvik, Laura J, Chen, Yii-Der Ida, Ding, Jingzhong, Lohman, Kurt, Kritchevsky, Stephen B, Zhao, Wei, Peyser, Patricia A, Kardia, Sharon L R, Kabagambe, Edmond, Broeckel, Ulrich, Chen, Guanjie, Zhou, Jie, Wassertheil-Smoller, Sylvia, Neuhouser, Marian L, Rampersaud, Evadnie, Psaty, Bruce, Kooperberg, Charles, Manson, Joann E, Kuller, Lewis H, Ochs-Balcom, Heather M, Johnson, Karen C, Sucheston, Lara, Ordovas, Jose M, Palmer, Julie R, Haiman, Christopher A, McKnight, Barbara, Howard, Barbara V, Becker, Diane M, Bielak, Lawrence F, Liu, Yongmei, Allison, Matthew A, Grant, Struan F A, Burke, Gregory L, Patel, Sanjay R, Schreiner, Pamela J, Borecki, Ingrid B, Evans, Michele K, Taylor, Herman, Sale, Michele M, Howard, Virginia, Carlson, Christopher S, Rotimi, Charles N, Cushman, Mary, Harris, Tamara B, Reiner, Alexander P, Cupples, L Adrienne, North, Kari E, Fox, Caroline S

“…Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately…”
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Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction by Palmer, Nicholette D, Kahali, Bratati, Kuppa, Annapurna, Chen, Yanhua, Du, Xiaomeng, Feitosa, Mary F, Bielak, Lawrence F, O'Connell, Jeffrey R, Musani, Solomon K, Guo, Xiuqing, Smith, Albert V, Ryan, Kathleen A, Eirksdottir, Gudny, Allison, Matthew A, Bowden, Donald W, Budoff, Matthew J, Carr, J Jeffrey, Chen, Yii-Der I, Taylor, Kent D, Correa, Adolfo, Crudup, Breland F, Halligan, Brian, Yang, Jian, Kardia, Sharon L R, Launer, Lenore J, Fu, Yi-Ping, Mosley, Thomas H, Norris, Jill M, Terry, James G, O'Donnell, Christopher J, Rotter, Jerome I, Wagenknecht, Lynne E, Gudnason, Vilmundur, Province, Michael A, Peyser, Patricia A, Speliotes, Elizabeth K

“…Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from…”
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