Search Results - "PETULLO, David M"

An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes by SOARS, Matthew G, PETULLO, David M, ECKSTEIN, James A, KASPER, Steve C, WRIGHTON, Steven A

“…Uridine diphosphate glucuronosyltransferases (UGTs) catalyze the glucuronidation of a wide range of xenobiotics and endogenous substrates. However, there is a…”
Get full text

THE USE OF A SUBSTRATE CASSETTE STRATEGY TO IMPROVE THE CAPACITY AND THROUGHPUT OF CYTOCHROME P450 INDUCTION STUDIES IN HUMAN HEPATOCYTES by MOHUTSKY, Michael A, PETULLO, David M, WRIGHTON, Steven A

“…The gold standard for estimating the ability of a new chemical entity to induce the human cytochromes P450 (P450s) is to determine the increase in catalytic…”
Get full text

A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro by Fayer, Jessica L, Petullo, David M, Ring, Barbara J, Wrighton, Steven A, Ruterbories, Kenneth J

“…Introduction: In order to examine CYP3A-mediated metabolism in vitro, a unique analytical assay was developed to detect the formation of 6β-hydroxytestosterone…”
Get full text