Search Results - "PETTERSEN, JOHN C."

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2) by Futatsugi, Kentaro, Kung, Daniel W, Orr, Suvi T. M, Cabral, Shawn, Hepworth, David, Aspnes, Gary, Bader, Scott, Bian, Jianwei, Boehm, Markus, Carpino, Philip A, Coffey, Steven B, Dowling, Matthew S, Herr, Michael, Jiao, Wenhua, Lavergne, Sophie Y, Li, Qifang, Clark, Ronald W, Erion, Derek M, Kou, Kou, Lee, Kyuha, Pabst, Brandon A, Perez, Sylvie M, Purkal, Julie, Jorgensen, Csilla C, Goosen, Theunis C, Gosset, James R, Niosi, Mark, Pettersen, John C, Pfefferkorn, Jeffrey A, Ahn, Kay, Goodwin, Bryan

“…The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit 1…”
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Discovery of a Clinical Candidate from the Structurally Unique Dioxa-bicyclo[3.2.1]octane Class of Sodium-Dependent Glucose Cotransporter 2 Inhibitors by Mascitti, Vincent, Maurer, Tristan S, Robinson, Ralph P, Bian, Jianwei, Boustany-Kari, Carine M, Brandt, Thomas, Collman, Benjamin M, Kalgutkar, Amit S, Klenotic, Michelle K, Leininger, Michael T, Lowe, André, Maguire, Robert J, Masterson, Victoria M, Miao, Zhuang, Mukaiyama, Emi, Patel, Jigna D, Pettersen, John C, Préville, Cathy, Samas, Brian, She, Li, Sobol, Zhanna, Steppan, Claire M, Stevens, Benjamin D, Thuma, Benjamin A, Tugnait, Meera, Zeng, Dongxiang, Zhu, Tong

“…Compound 4 (PF-04971729) belongs to a new class of potent and selective sodium-dependent glucose cotransporter 2 inhibitors incorporating a unique…”
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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis by Futatsugi, Kentaro, Cabral, Shawn, Kung, Daniel W., Huard, Kim, Lee, Esther, Boehm, Markus, Bauman, Jonathan, Clark, Ronald W., Coffey, Steven B., Crowley, Collin, Dechert-Schmitt, Anne-Marie, Dowling, Matthew S., Dullea, Robert, Gosset, James R., Kalgutkar, Amit S., Kou, Kou, Li, Qifang, Lian, Yajing, Loria, Paula M., Londregan, Allyn T., Niosi, Mark, Orozco, Christine, Pettersen, John C., Pfefferkorn, Jeffrey A., Polivkova, Jana, Ross, Trenton T., Sharma, Raman, Stock, Ingrid A., Tesz, Gregory, Wisniewska, Hanna, Goodwin, Bryan, Price, David A.

“…Discovery efforts leading to the identification of ervogastat (PF-06865571), a systemically acting diacylglycerol acyltransferase (DGAT2) inhibitor that has…”
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Harmonized 3Rs-based non-mutagenic impurity qualification study designs developed using the results of an IQ consortium survey by Mitra, Mayur S., Datta, Kaushik, Hutchinson, Richard, Nicolette, John J., Pettersen, John C., Wegesser, Teresa C., Bercu, Joel P.

“…As per the ICH Q3A(R2) and Q3B(R2) regulatory guidelines, safety studies may be needed when an impurity in new drug substances or products is above the…”
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Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator by Sharma, Raman, Litchfield, John, Atkinson, Karen, Eng, Heather, Amin, Neeta B, Denney, William S, Pettersen, John C, Goosen, Theunis C, Di, Li, Lee, Esther, Pfefferkorn, Jeffrey A, Dalvie, Deepak K, Kalgutkar, Amit S

“…The present article summarizes Metabolites in Safety Testing (MIST) studies on a glucokinase activator,…”
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The PPARα Agonists Fenofibrate and CP-778875 Cause Increased β-Oxidation, Leading to Oxidative Injury in Skeletal and Cardiac Muscle in the Rat by Pettersen, John C., Pruimboom-Brees, Ingrid, Francone, Omar L., Amacher, David E., Boldt, Sherri E., Kerlin, Roy L., Ballinger, William E.

“…Weak peroxisome proliferator–activated receptor (PPAR) α agonists (fibrates) are used to treat dyslipidemia. This study compared the effects of the potent and…”
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The Relationship of Glucokinase Activator–induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies by Pettersen, John C., Litchfield, John, Neef, Natasha, Schmidt, Stephen P., Shirai, Norimitsu, Walters, Karen M., Enerson, Bradley E., Chatman, Linda A., Pfefferkorn, Jeffrey A.

“…Glucokinase activators (GKAs) are being developed for the treatment of type 2 diabetes. The toxicity of 4 GKAs (PF-04279405, PF-04651887, piragliatin, and…”
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The Development of Subcutaneous Sarcomas in Rodents Exposed to Peroxisome Proliferators Agonists: Hypothetical Mechanisms of Action and De-Risking Attitude by Pruimboom-Brees, Ingrid M., Francone, Omar, Pettersen, John C., Kerlin, Roy L., Will, Yvonne, Amacher, David E., Boucher, Germaine G., Morton, Daniel

“…Peroxisome proliferator-activated receptors (PPARs) represent therapeutic targets for the management of type 2 diabetes mellitus and dyslipidemia. Rodent…”
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Neurotoxic Effects of Zoniporide: A Selective Inhibitor of the Na+/H+ Exchanger Isoform 1 by Pettersen, John C., Chouinard, Luc, Kerlin, Roy L., Groom, Simon N., Botts, Suzanne, Arezzo, Joseph C., Boucher, Mary A., Frazier, Donald E., Buchholz, Allan R.

“…Zoniporide, an inhibitor of the Na+-H+ exchanger-1, was administered by continuous intravenous infusion to rats and dogs for up to 1 month. In 1-month studies,…”
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Discovery and biological characterization of capromorelin analogues with extended half-lives by Carpino, Philip A., Lefker, Bruce A., Toler, Steven M., Pan, Lydia C., Hadcock, John R., Murray, Marianne C., Cook, Ewell R., DiBrino, Joseph N., DeNinno, Shari L., Chidsey-Frink, Kristin L., Hada, William A., Inthavongsay, John, Lewis, Sharon K., Mangano, F.Michael, Mullins, Michelle A., Nickerson, David F., Ng, Oicheng, Pirie, Christine M., Ragan, John A., Rose, Colin R., Tess, David A., Wright, Ann S., Yu, Li, Zawistoski, Michael P., Pettersen, John C., DaSilva-Jardine, Paul A., Wilson, Theresa C., Thompson, David D.

“…New tert-butyl, picolyl and fluorinated analogues of capromorelin ( 3), a short-acting growth hormone secretagogue (GHS), were prepared as part of a program to…”
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The effects of cyanide on brain mitochondrial cytochrome oxidase and respiratory activities by Pettersen, J C, Cohen, S D

“…Brain mitochondrial cytochrome oxidase and respiratory activities were compared after in vivo and in vitro exposure to cyanide. For the in vivo studies, mice…”
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Neurotoxic Effects of Zoniporide: A Selective Inhibitor of the Na super(+)/H super(+) Exchanger Isoform 1 by Pettersen, John C, Chouinard, Luc, Kerlin, Roy L, Groom, Simon N, Botts, Suzanne, Arezzo, Joseph C, Boucher, Mary A, Frazier, Donald E, Buchholz, Allan R

“…Zoniporide, an inhibitor of the Na super(+)-H super(+) exchanger-1, was administered by continuous intravenous infusion to rats and dogs for up to 1 month. In…”
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A 2-Year Comparison Study of Crl:CD BR and Hsd:Sprague-Dawley SD Rats by PETTERSEN, JOHN C., MORRISSEY, ROBERT L., SAUNDERS, DONALD R., PAVKOV, KENNETH L., LUEMPERT, LOUIS G., TURNIER, JOHN C., MATHESON, DALE W., SCHWARTZ, DANIEL R.

“…In this 2-year study, the suitability of the Hsd:Sprague-Dawley SD (SD) as a replacement for the Crl:CD BR (CD) rat was assessed by comparing survival rates,…”
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Twenty-six week toxicity study with KASAL® (basic sodium aluminum phosphate) in beagle dogs by Pettersen, J C, Hackett, D S, Zwicker, G M, Sprague, G L

“…Relatively few long-term studies in laboratory animals have been reported. Because sodium aluminum phosphate formulations are potentially important sources of…”
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Antagonism of cyanide poisoning by chlorpromazine and sodium thiosulfate by Pettersen, J C, Cohen, S D

“…Anti-cyanide action by sodium thiosulfate (ST) was enhanced by prior administration of chlorpromazine (CPZ). However, CPZ (alone) provided no protection…”
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A 2-Year Comparison Study of Crl:CD BR and Hsd:Sprague–Dawley SD Rats by Pettersen, John C., Morrissey, Robert L., Saunders, Donald R., Pavkov, Kenneth L., Luempert III, Louis G., Turnier, John C., Matheson, Dale W., Schwartz, Daniel R.

“…In this 2-year study, the suitability of the Hsd:Sprague–Dawley SD (SD) as a replacement for the Crl:CD BR (CD) rat was assessed by comparing survival rates,…”
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Noninvasive measurement of systemic arterial blood pressure in the conscious beagle dog by Pettersen, J C, Linartz, R R, Hamlin, R L, Stoll, R E

“…The objectives of this study were to evaluate a technique for routine, noninvasive measurement of systemic arterial blood pressure and heart rate (HR) in…”
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