Search Results - "PETROVAS, Constantinos"

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration by Cooper, Arik, García, Mayra, Petrovas, Constantinos, Yamamoto, Takuya, Koup, Richard A., Nabel, Gary J.

“…HIV-1 causes CD4 + T-cell death through viral integration by stimulation of DNA-dependent protein kinase (DNA-PK), a protein known to act in the p53 damage…”
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Editorial: Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure by Petrovas, Constantinos, Velu, Vijayakumar

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The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses by Moysi, Eirini, Petrovas, Constantinos, Koup, Richard A

“…The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no…”
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Editorial: CD4+ T cells in HIV: A Friend or a Foe? by Govindaraj, Sakthivel, Babu, Hemalatha, Kannanganat, Sunil, Vaccari, Monica, Petrovas, Constantinos, Velu, Vijayakumar

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Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection by Boswell, Kristin L, Paris, Robert, Boritz, Eli, Ambrozak, David, Yamamoto, Takuya, Darko, Sam, Wloka, Kaska, Wheatley, Adam, Narpala, Sandeep, McDermott, Adrian, Roederer, Mario, Haubrich, Richard, Connors, Mark, Ake, Julie, Douek, Daniel C, Kim, Jerome, Petrovas, Constantinos, Koup, Richard A

“…The interaction between follicular T helper cells (TFH) and B cells in the lymph nodes and spleen has a major impact on the development of antigen-specific B…”
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Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination by Amodio, Donato, Cotugno, Nicola, Macchiarulo, Giulia, Rocca, Salvatore, Dimopoulos, Yiannis, Castrucci, Maria Rita, De Vito, Rita, Tucci, Filippo M, McDermott, Adrian B, Narpala, Sandeep, Rossi, Paolo, Koup, Richard A, Palma, Paolo, Petrovas, Constantinos

“…Generation of Ag-specific humoral responses requires the orchestrated development and function of highly specialized immune cells in secondary lymphoid organs…”
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Immunogenicity of Protein Therapeutics: A Lymph Node Perspective by Fu, Kristy, March, Kylie, Alexaki, Aikaterini, Fabozzi, Giulia, Moysi, Eirini, Petrovas, Constantinos

“…The continuous development of molecular biology and protein engineering technologies enables the expansion of the breadth and complexity of protein…”
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RAIN: machine learning-based identification for HIV-1 bNAbs by Foglierini, Mathilde, Nortier, Pauline, Schelling, Rachel, Winiger, Rahel R., Jacquet, Philippe, O’Dell, Sijy, Demurtas, Davide, Mpina, Maxmillian, Lweno, Omar, Muller, Yannick D., Petrovas, Constantinos, Daubenberger, Claudia, Perreau, Matthieu, Doria-Rose, Nicole A., Gottardo, Raphael, Perez, Laurent

“…Broadly neutralizing antibodies (bNAbs) are promising candidates for the treatment and prevention of HIV-1 infections. Despite their critical importance,…”
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A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells by Joo, Victor, Petrovas, Constantinos, de Leval, Laurence, Noto, Alessandra, Obeid, Michel, Fenwick, Craig, Pantaleo, Giuseppe

“…Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical…”
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Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes by Watson, Dionysios C, Moysi, Eirini, Valentin, Antonio, Bergamaschi, Cristina, Devasundaram, Santhi, Fortis, Sotirios P, Bear, Jenifer, Chertova, Elena, Bess, Jr, Julian, Sowder, Ray, Venzon, David J, Deleage, Claire, Estes, Jacob D, Lifson, Jeffrey D, Petrovas, Constantinos, Felber, Barbara K, Pavlakis, George N

“…B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly…”
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Visualizing the Immune System: Providing Key Insights into HIV/SIV Infections by Estes, Jacob D, LeGrand, Roger, Petrovas, Constantinos

“…Immunological inductive tissues, such as secondary lymphoid organs, are composed of distinct anatomical microenvironments for the generation of immune…”
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Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates by Francica, Joseph R, Laga, Richard, Lynn, Geoffrey M, Mužíková, Gabriela, Androvič, Ladislav, Aussedat, Baptiste, Walkowicz, William E, Padhan, Kartika, Ramirez-Valdez, Ramiro Andrei, Parks, Robert, Schmidt, Stephen D, Flynn, Barbara J, Tsybovsky, Yaroslav, Stewart-Jones, Guillaume B E, Saunders, Kevin O, Baharom, Faezzah, Petrovas, Constantinos, Haynes, Barton F, Seder, Robert A

“…Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other…”
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Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections by Promsote, Wanwisa, Xu, Ling, Hataye, Jason, Fabozzi, Giulia, March, Kylie, Almasri, Cassandra G., DeMouth, Megan E., Lovelace, Sarah E., Talana, Chloe Adrienna, Doria-Rose, Nicole A., McKee, Krisha, Hait, Sabrina Helmold, Casazza, Joseph P., Ambrozak, David, Beninga, Jochen, Rao, Ercole, Furtmann, Norbert, Birkenfeld, Joerg, McCarthy, Elizabeth, Todd, John-Paul, Petrovas, Constantinos, Connors, Mark, Hebert, Andrew T., Beck, Jeremy, Shen, Junqing, Zhang, Bailin, Levit, Mikhail, Wei, Ronnie R., Yang, Zhi-yong, Pegu, Amarendra, Mascola, John R., Nabel, Gary J., Koup, Richard A.

“…Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising…”
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Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective by Aid, Malika, Dupuy, Frank P, Moysi, Eirini, Moir, Susan, Haddad, Elias K, Estes, Jacob D, Sekaly, Rafick Pierre, Petrovas, Constantinos, Ribeiro, Susan Pereira

“…Effective antiretroviral therapy (ART) has prevented the progression to AIDS and reduced HIV-related morbidities and mortality for the majority of infected…”
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HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue by Reuter, Morgan A., Del Rio Estrada, Perla M., Buggert, Marcus, Petrovas, Constantinos, Ferrando-Martinez, Sara, Nguyen, Son, Sada Japp, Alberto, Ablanedo-Terrazas, Yuria, Rivero-Arrieta, Amaranta, Kuri-Cervantes, Leticia, Gunzelman, Heidi M., Gostick, Emma, Price, David A., Koup, Richard A., Naji, Ali, Canaday, David H., Reyes-Terán, Gustavo, Betts, Michael R.

“…Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8+ T cells play a critical role in control of HIV, but their…”
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Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence by Pino, Maria, Paganini, Sara, Deleage, Claire, Padhan, Kartika, Harper, Justin L, King, Colin T, Micci, Luca, Cervasi, Barbara, Mudd, Joseph C, Gill, Kiran P, Jean, Sherrie M, Easley, Kirk, Silvestri, Guido, Estes, Jacob D, Petrovas, Constantinos, Lederman, Michael M, Paiardini, Mirko

“…Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing…”
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Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection by Dias, Joana, Fabozzi, Giulia, Fourati, Slim, Chen, Xuejun, Liu, Cuiping, Ambrozak, David R., Ransier, Amy, Laboune, Farida, Hu, Jianfei, Shi, Wei, March, Kylie, Maximova, Anna A., Schmidt, Stephen D., Samsel, Jakob, Talana, Chloe A., Ernste, Keenan, Ko, Sung Hee, Lucas, Margaret E., Radecki, Pierce E., Boswell, Kristin L., Nishimura, Yoshiaki, Todd, John-Paul, Martin, Malcolm A., Petrovas, Constantinos, Boritz, Eli A., Doria-Rose, Nicole A., Douek, Daniel C., Sékaly, Rafick-Pierre, Lifson, Jeffrey D., Asokan, Mangaiarkarasi, Gama, Lucio, Mascola, John R., Pegu, Amarendra, Koup, Richard A.

“…Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab…”
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In Situ Characterization of Follicular Helper CD4 T Cells Using Multiplexed Imaging by Ioannidou, Kalliopi, Ndiaye, Daba-Rokhya, Noto, Alessandra, Fenwick, Craig, Fortis, Sotirios P, Pantaleo, Giuseppe, Petrovas, Constantinos, de Leval, Laurence

“…Follicular helper CD4 T (Tfh) cells play an essential role in the formation of germinal centers (GCs), where mature B cells proliferate, differentiate, and…”
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In Situ Characterization of Human Lymphoid Tissue Immune Cells by Multispectral Confocal Imaging and Quantitative Image Analysis; Implications for HIV Reservoir Characterization by Moysi, Eirini, Del Rio Estrada, Perla M., Torres-Ruiz, Fernanda, Reyes-Terán, Gustavo, Koup, Richard A., Petrovas, Constantinos

“…CD4 T cells are key mediators of adaptive immune responses during infection and vaccination. Within secondary lymphoid organs, helper CD4 T cells, particularly…”
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Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells by Abdi, Kaveh, Laky, Karen, Padhan, Kartika, Petrovas, Constantinos, Skinner, Jeff, Kabat, Juraj, Dorward, David W, Brzostowski, Joseph, Long, Eric O, Trinchieri, Giorgio, Varma, Rajat

“…Early secretion of IL-12 by mouse dendritic cells (DCs) instructs T cells to make IFN-γ. However, only activated, but not naive T cells are able to license DCs…”
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