Search Results - "PETRENKO, Oleksi"

KRAS drives immune evasion in a genetic model of pancreatic cancer by Ischenko, Irene, D’Amico, Stephen, Rao, Manisha, Li, Jinyu, Hayman, Michael J., Powers, Scott, Petrenko, Oleksi, Reich, Nancy C.

“…Immune evasion is a hallmark of KRAS-driven cancers, but the underlying causes remain unresolved. Here, we use a mouse model of pancreatic ductal…”
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STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer by D'Amico, Stephen, Kirillov, Varvara, Petrenko, Oleksi, Reich, Nancy C

“…Oncogenic mutations in KRAS are among the most common in cancer. Classical models suggest that loss of epithelial characteristics and the acquisition of…”
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Direct reprogramming by oncogenic Ras and Myc by Ischenko, Irene, Zhi, Jizu, Moll, Ute M., Nemajerova, Alice, Petrenko, Oleksi

“…Genetically or epigenetically defined reprogramming is a hallmark of cancer cells. However, a causal association between genome reprogramming and cancer has…”
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The MDM2-p53 Interaction by Moll, Ute M, Petrenko, Oleksi

“…Activation of the p53 protein protects the organism against the propagation of cells that carry damaged DNA with potentially oncogenic mutations. MDM2, a…”
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Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas by Ischenko, Irene, Petrenko, Oleksi, Hayman, Michael J.

“…Pancreatic cancer is one of the deadliest human malignancies. A striking feature of pancreatic cancer is that activating Kras mutations are found in ∼90% of…”
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Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer by Sivaram, Nithya, McLaughlin, Patrick A, Han, Han V, Petrenko, Oleksi, Jiang, Ya-Ping, Ballou, Lisa M, Pham, Kien, Liu, Chen, van der Velden, Adrianus W.M, Lin, Richard Z

“…The presence of tumor-infiltrating T cells is associated with favorable patient outcomes, yet most pancreatic cancers are immunologically silent and resistant…”
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A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells by Ischenko, Irene, Petrenko, Oleksi, Hayman, Michael J

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive, metastatic disease with limited treatment options. Factors contributing to the metastatic…”
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p53 Has a Direct Apoptogenic Role at the Mitochondria by Mihara, Motohiro, Erster, Susan, Zaika, Alexander, Petrenko, Oleksi, Chittenden, Thomas, Pancoska, Petr, Moll, Ute M.

“…p53 induces apoptosis by target gene regulation and transcription-independent signaling. However, a mechanism for the latter was unknown. We recently reported…”
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IL-6 promotes MYC-induced B cell lymphomagenesis independent of STAT3 by Petrenko, Oleksi, Li, Jinyu, Cimica, Velasco, Mena-Taboada, Patricio, Shin, Ha Youn, D'Amico, Stephen, Reich, Nancy C

“…The inflammatory cytokine IL-6 is known to play a causal role in the promotion of cancer, although the underlying mechanisms remain to be completely…”
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In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation by Erster, Susan, Mihara, Motohiro, Kim, Roger H., Petrenko, Oleksi, Moll, Ute M.

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ΔNp73 Facilitates Cell Immortalization and Cooperates with Oncogenic Ras in Cellular Transformation In Vivo by Petrenko, Oleksi, Zaika, Alexander, Moll, Ute M.

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Mitochondrially targeted p53 has tumor suppressor activities in vivo by TALOS, Flaminia, PETRENKO, Oleksi, MENA, Patricio, MOLL, Ute M

“…Complex proapoptotic functions are essential for the tumor suppressor activity of p53. We recently described a novel transcription-independent mechanism that…”
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A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism by Nikiforov, Mikhail A., Chandriani, Sanjay, O'Connell, Brenda, Petrenko, Oleksi, Kotenko, Iulia, Beavis, Andrew, Sedivy, John M., Cole, Michael D.

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Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis by Nemajerova, Alice, Palacios, Gustavo, Nowak, Norma J, Matsui, Sei-Ichi, Petrenko, Oleksi

“…Transcriptional silencing of the p73 gene through methylation has been demonstrated in human leukemias and lymphomas. However, the role of p73 in the malignant…”
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Macrophage Migration Inhibitory Factor Coordinates DNA Damage Response with the Proteasomal Control of the Cell Cycle by Nemajerova, Alice, Moll, Ute M., Petrenko, Oleksi, Fingerle-Rowson, Günter

“…Proper repair of DNA damage is critical for protecting genomic stability, cellular viability and suppression of tumorigenesis. Both p53-dependent and…”
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MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models by Fingerle-Rowson, Günter, Petrenko, Oleksi

“…Macrophage migration inhibitory factor (MIF) is a ubiquitously expressed pro-inflammatory mediator that has also been implicated in the process of oncogenic…”
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E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression by Palacios, Gustavo, Talos, Flaminia, Nemajerova, Alice, Moll, Ute M, Petrenko, Oleksi

“…To better understand the role of E2F1 in tumor formation, we analyzed spontaneous tumorigenesis in p53-/-E2F1+/+ and p53-/-E2F1-/- mice. We show that the…”
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Macrophage Migration Inhibitory Factor Deficiency Is Associated with Altered Cell Growth and Reduced Susceptibility to Ras-mediated Transformation by Petrenko, O, Fingerle-Rowson, G, Peng, T, Mitchell, R A, Metz, C N

“…Macrophage migration inhibitory factor (MIF) has been shown to functionally inactivate the p53 tumor suppressor and to inhibit p53-responsive gene expression…”
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Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase by ISCHENKO, Irene, PETRENKO, Oleksi, GU, Haihua, HAYMAN, Michael J

“…Transformation of fibroblasts by V-SEA involves activation of the ERK and phosphatidylinositol 3-kinase (PI3K) pathways. Effector proteins that are key…”
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STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer by D'Amico, Stephen, Kirillov, Varvara, Petrenko, Oleksi, Reich, Nancy C

“…Oncogenic mutations in KRAS are among the most common in cancer. Classical models suggest that loss of epithelial characteristics and the acquisition of…”
Get full text