Search Results - "PETITOU, M"

Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as potent angiogenesis and heparanase inhibitor for cancer applications by Kuhnast, B, El Hadri, A, Boisgard, R, Hinnen, F, Richard, S, Caravano, A, Nancy-Portebois, V, Petitou, M, Tavitian, B, Dollé, F

“…Heparan Sulfate (HS) mimetics are able to block crucial interactions of the components of the extracellular matrix in angiogenic processes and as such,…”
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Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy by SAVI, P., HERAULT, J. P., DUCHAUSSOY, P., MILLET, L., SCHAEFFER, P., PETITOU, M., BONO, F., HERBERT, J. M.

“…Objective: In order to obtain a neutralizable antithrombotic, a chimeric molecule (SSR126517E) containing the sequence of a long‐lasting antithrombin…”
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First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action by Gueret, Pierre, Combe, S., Krezel, C., Fuseau, E., van Giersbergen, P. L. M., Petitou, M., Neuhart, E.

“…Summary EP217609 is a parenteral antithrombotic compound combining in one molecule an indirect anti-factor Xa inhibitor, a direct thrombin active site…”
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Neutralization of EP217609, a new dual-action FIIa/FXa anticoagulant, by its specific antidote avidin: a phase I study by Gueret, P., Combe, S., Krezel, C., Fuseau, E., van Giersbergen, P. L. M., Petitou, M., Neuhart, E.

“…Introduction EP217609 is a representative of a new class of synthetic parenteral anticoagulants with a dual mechanism of action. It combines in a single…”
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EP42675, a synthetic parenteral dual‐action anticoagulant: pharmacokinetics, pharmacodynamics, and absence of interactions with antiplatelet drugs by Gueret, P., Krezel, C., Fuseau, E., Giersbergen, P. L. M., Petitou, M., Neuhart, E.

“…Summary Background EP42675 is a first‐in‐class, synthetic, parenteral, anticoagulant combining in a single molecule a direct thrombin inhibitor and an indirect…”
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Biochemical and Pharmacological Properties of SANORG 34006, a Potent and Long-Acting Synthetic Pentasaccharide by Herbert, J.M., Hérault, J.P., Bernat, A., van Amsterdam, R.G.M., Lormeau, J.C., Petitou, M., van Boeckel, C., Hoffmann, P., Meuleman, D.G.

“…SANORG 34006 is a new sulfated pentasaccharide obtained by chemical synthesis. It is an analog of the “synthetic pentasaccharide” (SR 90107/ ORG 31540) which…”
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Conformation of heparin pentasaccharide bound to antithrombin III by Hricovíni, M, Guerrini, M, Bisio, A, Torri, G, Petitou, M, Casu, B

“…The interaction, in aqueous solution, of the synthetic pentasaccharide AGA*IA(M) (GlcN,6-SO(3)alpha 1-4GlcA beta 1-4GlcN,3,6-SO(3)alpha 1-4IdoA,2-SO(3)alpha…”
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Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy by SAVI, P., HERAULT, J.P., DUCHAUSSOY, P., MILLET, L., SCHAEFFER, P., PETITOU, M., BONO, F., HERBERT, J.M.

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SR123781A, a synthetic heparin mimetic by Herbert, J M, Hérault, J P, Bernat, A, Savi, P, Schaeffer, P, Driguez, P A, Duchaussoy, P, Petitou, M

“…SR123781A, a synthetic hexadecasaccharide comprising an antithrombin (AT) binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide…”
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Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans by Casu, B, Petitou, M, Provasoli, M, Sinaÿ, P

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1976–1983, a critical period in the history of heparin: the discoveryof the antithrombin binding site by Petitou, Maurice, Casu, Benito, Lindahl, Ulf

“…Heparin inhibits blood coagulation by binding to the protease inhibitor antithrombin, thus promoting inactivation of the protease “factors” of the coagulation…”
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Pharmacokinetics of new synthetic heparin mimetics by Hérault, J P, Bernat, A, Roye, F, Michaux, C, Schaeffer, P, Bono, F, Petitou, M, Herbert, J M

“…Pharmacokinetics of oligosaccharides displaying various affinities for antithrombin (AT) allowed us to show that there was a close relationship between the…”
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The structure of synthetic oligosaccharides in relation to factor IXa inhibition by Hérault, J P, Gaich, C, Bono, F, Driguez, P A, Duchaussoy, P, Petitou, M, Herbert, J M

“…We investigated the effect of various oligosaccharides (OS) on the inhibition of factor IXa by antithrombin (AT) in a purified system. The OS comprised the…”
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Experimental Proof for the Structure of a Thrombin-Inhibiting Heparin Molecule by Petitou, Maurice, Imberty, Anne, Duchaussoy, Philippe, Driguez, Pierre-Alexandre, Ceccato, Marie-Line, Gourvenec, Françoise, Sizun, Philippe, Hérault, Jean-Pascal, Pérez, Serge, Herbert, Jean-Marc

“…Kinetic studies of thrombin inhibition by antithrombin in the presence of heparin have shown that thrombin binds to heparin in a preformed heparin–antithrombin…”
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Comparative effects of two synthetic oligosaccharides on platelet activation induced by plasma from HIT patients by Savi, P., Pflieger, A‐M., Hérault, J‐P., Michaux, C., Duchaussoy, P., Petitou, M., Herbert, J‐M.

“…Heparin‐induced thrombocytopenia (HIT) is a serious secondary event encountered in the clinical use of heparin. HIT results from the consumption of platelets…”
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Biochemical and Pharmacological Properties of SANORG 32701: Comparison With the `Synthetic Pentasaccharide' (SR 90107/ORG 31540) and Standard Heparin by Herbert, J.M, Herault, J.P, Bernat, A, van Amsterdam, R.G.M, Vogel, G.M.T, Lormeau, J.C, Petitou, M, Meuleman, D.G

“…SANORG 32701 is a new sulfated pentasaccharide obtained by total chemical synthesis. It is an analogue of the ``synthetic pentasaccharide'' (SR 90107/ORG…”
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Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators by Han, Z. C., Bellucci, S., Shen, Z. X., Maffrand, J. P., Pascal, M., Petitou, M., Lormeau, J., Caen, J. P.

“…We have previously reported that heparin is capable of stimulating in vitro and in vivo megakaryocytopoiesis in mice and has a thrombopoietic effect when given…”
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A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next? by Petitou, Maurice, van Boeckel, Constant A. A.

“…Heparin is a sulfated glycosaminoglycan isolated from animal organs that has been used clinically as an antithrombotic agent since the 1940s. In the early…”
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Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity by Choay, J, Petitou, M, Lormeau, J C, Sinaÿ, P, Casu, B, Gatti, G

“…The structures of the tetrasaccharide (beta-D-glucuronic acid)1 leads to 4 (N-sulfate-3,6-di-0-sulfate-alpha-D-glucosamine)1 leads to…”
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Inhibition of leucocyte elastase by heparin and its derivatives by Redini, F, Tixier, J M, Petitou, M, Choay, J, Robert, L, Hornebeck, W

“…Leucocyte proteinases, e.g. leucocyte elastase and cathepsin G, are inhibited by heparin. The activities of pig pancreatic and Pseudomonas aeruginosa elastases…”
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