Search Results - "PESCHANSKI, M"

Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening by Boissart, C, Poulet, A, Georges, P, Darville, H, Julita, E, Delorme, R, Bourgeron, T, Peschanski, M, Benchoua, A

“…Cortical neurons of the superficial layers (II-IV) represent a pivotal neuronal population involved in the higher cognitive functions of the human and are…”
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Factors predictive of leg‐ulcer healing in sickle cell disease: a multicentre, prospective cohort study by Senet, P., Blas‐Chatelain, C., Levy, P., Manea, E.M., Peschanski, M., Mirault, T., Stankovic‐Stojanovic, K., Debure, C., Debbache, K., Girot, R., Bureau, J.‐M., Bachmeyer, C., Baldeschi, C., Galacteros, F., Lionnet, F., Gellen‐Dautremer, J.

“…Summary Background Leg ulcers (LUs) are a chronic and severe complication of sickle cell disease (SCD). A prospective study in patients with SCD to identify…”
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Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study by Bloch, J, Bachoud-Lévi, A C, Déglon, N, Lefaucheur, J P, Winkel, L, Palfi, S, Nguyen, J P, Bourdet, C, Gaura, V, Remy, P, Brugières, P, Boisse, M-F, Baudic, S, Cesaro, P, Hantraye, P, Aebischer, P, Peschanski, M

“…Huntington's disease (HD) is a monogenic neurodegenerative disease that affects the efferent neurons of the striatum. The protracted evolution of the pathology…”
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Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation by Blondel, S, Egesipe, A-L, Picardi, P, Jaskowiak, A-L, Notarnicola, M, Ragot, J, Tournois, J, Le Corf, A, Brinon, B, Poydenot, P, Georges, P, Navarro, C, pitrez, P R, Ferreira, L, Bollot, G, Bauvais, C, Laustriat, D, Mejat, A, De Sandre-Giovannoli, A, Levy, N, Bifulco, M, Peschanski, M, Nissan, X

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by a dramatic appearance of premature aging. HGPS is due to a single-base…”
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S.12.02 A human pluripotent stem cell-derived neuronal model for characterisation of pathways regulating the autism and schizophrenia-related gene SHANK-3 by Darville, H, Poulet, A, Pernelle, J, Delorme, R, Coge, F, Millan, M.J, Bourgeron, T, Peschanski, M, Benchoua, A

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Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF by Bachoud-Lévi, A C, Déglon, N, Nguyen, J P, Bloch, J, Bourdet, C, Winkel, L, Rémy, P, Goddard, M, Lefaucheur, J P, Brugières, P, Baudic, S, Cesaro, P, Peschanski, M, Aebischer, P

“…Huntington's disease (HD) is an autosomal dominant genetic disease with devastating clinical effects on cognitive, psychological, and motor functions. These…”
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Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington’s disease by Peschanski, Marc, Bachoud‐Lévi, Anne‐Catherine, Hantraye, Philippe

“…Fetal neural transplants have become clinically relevant over the past 15 years for two major neurodegenerative diseases, namely Parkinson’s disease and…”
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Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease by Peschanski, M., Cesaro, P., Hantraye, P.

“…Huntington's disease is a genetic disease, autosomal and dominant, that induces motor disorders, an inexorable deterioration of higher brain functions and…”
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Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease by Bachoud-Lévi, A.-C., Bourdet, C., Brugières, P., Nguyen, J.-P., Grandmougin, T., Haddad, B., Jény, R., Bartolomeo, P., Boissé, M.-F., Barba, G.Dalla, Degos, J.-D., Ergis, A.-M., Lefaucheur, J.-P., Lisovoski, F., Pailhous, E., Rémy, P., Palfi, S., Defer, G.L., Cesaro, P., Hantraye, P., Peschanski, M.

“…This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease…”
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Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon by Peschanski, M, Defer, G, N'Guyen, J P, Ricolfi, F, Monfort, J C, Remy, P, Geny, C, Samson, Y, Hantraye, P, Jeny, R

“…Several recent reports have suggested that foetal ventral mesencephalic transplants could alleviate motor symptoms in patients with Parkinson's disease…”
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Correlation of in vitro infiltration with glioma histological type in organotypic brain slices by PALFI, S, SWANSON, K. R, DE BOÜARD, S, CHRETIEN, F, OLIVEIRA, R, GHERARDI, R. K, KROS, J. M, PESCHANSKI, M, CHRISTOV, C

“…Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal…”
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Pig xenografts to the immunocompetent rat brain: Survival rates using distinct neurotoxic lesions in the nigrostriatal pathway and two rat strains by Robichon, R., Jaafar, A., Terqui, M., Brachet, P., Peschanski, M.

“…Porcine foetal neurons for xenotransplantation in Parkinson's disease (PD) is an alternative source to human fetuses. One of the obstacles facing brain…”
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Retest effects and cognitive decline in longitudinal follow-up of patients with early HD by BACHOUD-LEVI, A.-C, MAISON, P, BARTOLOMEO, P, BOISSE, M.-F, BARBA, G. Dalla, ERGIS, A.-M, BAUDIC, S, DEGOS, J.-D, CESARO, P, PESCHANSKI, M

“…To assess the natural progression of cognitive impairment in Huntington's disease (HD) and to reveal factors that may mask this progression. Although numerous…”
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Glial changes following an excitotoxic lesion in the CNS--I. Microglia/macrophages by Marty, S, Dusart, I, Peschanski, M

“…When an area of the adult rat CNS is depleted of neurons by an in situ excitotoxic injection, afferent axons to the area exhibit morphological alterations…”
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Trigeminal afferents to the diencephalon in the rat by Peschanski, M

“…Trigemino-diencephalic connections were studied in the rat using wheat-germ agglutinin conjugated to horseradish peroxidase as an anterogradely transported…”
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Glial changes following an excitotoxic lesion in the CNS--II. Astrocytes by Dusart, I, Marty, S, Peschanski, M

“…Astrocytes are involved, as are microglia/macrophages [Marty et al. (1991) Neuroscience 45, 529-539], in the formation of a glial scar after CNS lesions. This…”
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Direct myocardial implantation of human embryonic stem cells in a dog model of Duchenne cardiomyopathy reveals poor cell survival in dystrophic tissue by Habeler, W, Ghaleh, B, Barthelemy, I, Plancheron, A, Bizé, A, Carlos-Sampedrano, C, Chetboul, V, Berdeaux, A, Pucéat, M, Peschanski, M, Blot, S, Monville, C

“…Duchenne muscular dystrophy is characterized by progressive muscle weakness and early death resulting from dystrophin deficiency. Spontaneous canine muscular…”
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The breaking of embargoes by Peschanski, Marc

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Transfer of a foreign gene into the brain using adenovirus vectors by Poenaru, Livia, Vigne, Emmanuelle, Peschanski, Marc R, Akli, Saïd, Caillaud, Catherine, Perricaudet, Michel, Stratford-Perricaudet, Leslie D, Kahn, Axel

“…The ability of a replication-deficient adenovirus vector to transfer a foreign gene into neural cells of adult rats in vivo has been analysed. A large number…”
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Efficient early and sustained transduction of human fetal mesencephalon using adeno-associated virus type 2 vectors by Tenenbaum, L, Peschanski, M, Melas, C, Rodesh, F, Lehtonen, E, Stathopoulos, A, Velu, T, Brotchi, J, Levivier, M

“…The success of transplantation of human fetal mesencephalic tissue into the putamen of patients with Parkinson's disease (PD) is still limited by the poor…”
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