Search Results - "PERVIN, Shehla"

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues by Singh, Rajan, Barrios, Albert, Dirakvand, Golnaz, Pervin, Shehla

“…Obesity-associated metabolic abnormalities comprise a cluster of conditions including dyslipidemia, insulin resistance, diabetes and cardiovascular diseases…”
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Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders by Pervin, Shehla, Reddy, Srinivasa T, Singh, Rajan

“…Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and…”
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Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues by Singh, Rajan, Braga, Melissa, Reddy, Srinivasa T., Lee, Se-Jin, Parveen, Meher, Grijalva, Victor, Vergnes, Laurent, Pervin, Shehla

“…We previously demonstrated that Fst expression is highest in brown adipose tissue (BAT) and skeletal muscle, but is also present at substantial levels in…”
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Follistatin promotes adipocyte differentiation, browning, and energy metabolism[S] by Braga, Melissa, Reddy, Srinivasa T., Vergnes, Laurent, Pervin, Shehla, Grijalva, Victor, Stout, David, David, John, Li, Xinmin, Tomasian, Venina, Reid, Christopher B., Norris, Keith C., Devaskar, Sherin U., Reue, Karen, Singh, Rajan

“…Follistatin (Fst) functions to bind and neutralize the activity of members of the transforming growth factor-β superfamily. Fst has a well-established role in…”
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Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells : Involvement of mammalian target of rapamycin/eIF4E pathway by PERVIN, Shehla, SINGH, Rajan, HERNANDEZ, Estebes, GUOYAO WU, CHAUDHURI, Gautam

“…Nitric oxide (NO) in nanomolar (nmol/L) concentrations is consistently detected in tumor microenvironment and has been found to promote tumorigenesis. The…”
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Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice by Singh, Rajan, Parveen, Meher, Basgen, John M, Fazel, Sayeda, Meshesha, Meron F, Thames, Easter C, Moore, Brandis, Martinez, Luis, Howard, Carolyn B, Vergnes, Laurent, Reue, Karen, Pervin, Shehla

“…The initiation and progression of breast cancer is a complex process that is influenced by heterogeneous cell populations within the tumor microenvironment…”
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Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy by Pervin, Shehla, Hewison, Martin, Braga, Melissa, Tran, Lac, Chun, Rene, Karam, Amer, Chaudhuri, Gautam, Norris, Keith, Singh, Rajan

“…Vitamin D signaling in mammary cancer stem cells (MCSCs), which are implicated in the initiation and progression of breast cancer, is poorly understood. In…”
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Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth by Pervin, Shehla, Singh, Rajan, Sinha, Satyesh, Collazo, Javier, Tucker, Alexandria, Singh, Vineeta, Vadgama, Jaydutt, Friedman, Theodore, Jimenez, Thalia, Hikim, Amiya Sinha

“…Breast cancer results from a complex interplay of genetics and environment that alters immune and inflammatory systems to promote tumorigenesis. Obesity and…”
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Proteomic identification of mitochondrial targets of arginase in human breast cancer by Singh, Rajan, Avliyakulov, Nuraly K, Braga, Melissa, Haykinson, Michael J, Martinez, Luis, Singh, Vikash, Parveen, Meher, Chaudhuri, Gautam, Pervin, Shehla

“…We have previously reported arginase expression in human breast cancer cells and demonstrated that the inhibition of arginase by N(ω) hydroxy L-arginine (NOHA)…”
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NO to breast: when, why and why not? by Pervin, Shehla, Chaudhuri, Gautam, Singh, Rajan

“…Nitric oxide is a pleiotropic ancestral molecule, which elicits beneficial effect in many physiological settings but is also tenaciously expressed in numerous…”
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Nitric Oxide-Induced Cytostasis and Cell Cycle Arrest of a Human Breast Cancer Cell Line (MDA-MB-231): Potential Role of Cyclin D1 by Pervin, Shehla, Singh, Rajan, Chaudhuri, Gautam

“…DETA-NONOate, a nitric oxide (NO) donor, induced cytostasis in the human breast cancer cells MDA-MB-231, and the cells were arrested in the G1 phase of the…”
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A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors by Miranda-Carboni, Gustavo A, Krum, Susan A, Yee, Kathleen, Nava, Miguel, Deng, Qiming E, Pervin, Shehla, Collado-Hidalgo, Alicia, Galic, Zoran, Zack, Jerome A, Nakayama, Keiko, Nakayama, Keiichi I, Lane, Timothy F

“…Loss of the CDK inhibitor p27(KIP1) is widely linked with poor prognosis in human cancer. In Wnt10b-expressing mammary tumors, levels of p27(KIP1) were…”
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Correction: Proteomic Identification of Mitochondrial Targets of Arginase in Human Breast Cancer by Singh, Rajan, Avliyakulov, Nuraly K., Braga, Melissa, Haykinson, Michael J., Martinez, Luis, Singh, Vikash, Parveen, Meher, Chaudhuri, Gautam, Pervin, Shehla

“…Download corrected item. https://doi.org/10.1371/annotation/7e9bf57e-a45f-4a22-95ee-eece21d282c8.s001.cn Citation: Singh R, Avliyakulov NK, Braga M, Haykinson…”
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Castration Increases and Androgens Decrease Nitric Oxide Synthase Activity in the Brain: Physiologic Implications by Singh, Rajan, Pervin, Shehla, Shryne, James, Gorski, Roger, Chaudhuri, Gautam

“…Sex differences in nitric oxide synthase (NOS) activity in different regions of the rat brain and effects of testosterone and dihydrotestosterone (DHT)…”
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Abstract P6-06-12: Upregulation of beige adipocytes in African-American triple negative breast tumors induce tumorigenesis by promoting anti-inflammatory microenvironment by Moore, Brandis A., Osorio, Briana, Singh, Rajan, Pervin, Shehla

“…Abstract Background: The complexity of breast cancer (BC) development and progression is heavily influenced by the cross-talk of critical cell types within the…”
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Inhibition of in vitro and in vivo brown fat differentiation program by myostatin by Braga, Melissa, Pervin, Shehla, Norris, Keith, Bhasin, Shalender, Singh, Rajan

“…Objective: Obesity arises mainly due to the imbalance between energy storage and its expenditure. Metabolically active brown adipose tissue (BAT) has recently…”
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Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: Potential role of follistatin in mediating testosterone action by Braga, Melissa, Bhasin, Shalender, Jasuja, Ravi, Pervin, Shehla, Singh, Rajan

“…Testosterone (T) administration is associated with increased satellite cell number and skeletal muscle hypertrophy, although there is considerable…”
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Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis by Martinez, Luis, Thames, Easter, Kim, Jinna, Chaudhuri, Gautam, Singh, Rajan, Pervin, Shehla

“…Breast cancer is a complex heterogeneous disease where many distinct subtypes are found. Younger African American (AA) women often present themselves with…”
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Modulation of transforming growth factor-β/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders by Pervin, Shehla, Singh, Vineeta, Tucker, Alexandria, Collazo, Javier, Singh, Rajan

“…Obesity is a major risk factor for the development of diabetes, insulin resistance, dyslipidemia, cardiovascular disease and other related metabolic…”
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Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ β-Catenin and Follistatin/Transforming Growth Factor-β Signaling Pathways by Singh, Rajan, Bhasin, Shalender, Braga, Melissa, Artaza, Jorge N, Pervin, Shehla, Taylor, Wayne E, Krishnan, Venkatesh, Sinha, Satyesh K, Rajavashisth, Tripathi B, Jasuja, Ravi

“…Androgens are important regulators of body composition and promote myogenic differentiation and inhibit adipogenesis of mesenchymal, multipotent cells. Here,…”
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