Search Results - "PERS, J. O"

Are the B cells cast with the leading part in the Sjogren's syndrome scenario? by Pers, J-O, Youinou, P

“…The autoimmune exocrinopathy Sjögren's syndrome (SS) is characterized by mononuclear cell (MNC) infiltrates of exocrine glands and overactivity of B…”
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B-Cells induce regulatory T cells through TGF-β/IDO production in A CTLA-4 dependent manner by Nouël, A, Pochard, P, Simon, Q, Ségalen, I, Le Meur, Y, Pers, J.O, Hillion, S

“…Abstract A number of studies have suggested that B cell mediated-regulation contributes to the establishment of immunological tolerance. However, the precise…”
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Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration by Konsta, O.D, Le Dantec, C, Charras, A, Cornec, D, Kapsogeorgou, E.K, Tzioufas, A.G, Pers, J.O, Renaudineau, Y

“…Abstract The pathogenesis of primary Sjögren's syndrome (pSS) is complex, in part due to DNA methylation abnormalities. This study was undertaken to evaluate…”
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Is the blood B-cell subset profile diagnostic for Sjogren syndrome? by Binard, A, Le Pottier, L, Devauchelle-Pensec, V, Saraux, A, Youinou, P, Pers, J-O

“…To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome. The distribution of mature blood B cells from Bm1 through…”
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Role of B-cell antigen receptor-associated molecules and lipid rafts in CD5-induced apoptosis of B CLL cells by RENAUDINEAU, Y, NEDELLEC, S, BERTHOU, C, LYDYARD, P. M, YOUINOU, P, PERS, J-O

“…A total of 40 patients with B-CLL were investigated for CD5-triggered apoptosis and categorized as 20 resistant (group I) and 20 sensitive patients (group II)…”
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Salivary gland ultrasonography improves the diagnostic performance of the 2012 American College of Rheumatology classification criteria for Sjögren's syndrome by Cornec, Divi, Jousse-Joulin, Sandrine, Marhadour, Thierry, Pers, Jacques-Olivier, Boisramé-Gastrin, Sylvie, Renaudineau, Yves, Saraux, Alain, Devauchelle-Pensec, Valérie

“…The aim of this study was to evaluate whether salivary gland ultrasonography (SGUS) improves the diagnostic performance of the 2012 ACR classification criteria…”
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Viruses contribute to the development of Sjögren's syndrome by Youinou, P., Pers, J.‐O., Saraux, A., Pennec, Y.‐L.

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BAFF and rheumatic autoimmune disorders: implications for disease management and therapy by Bosello, S, Pers, J-O, Rochas, C, Devauchelle, V, De Santis, M, Daridon, C, Saraux, A, Ferraccioli, G F, Youinou, P

“…Interest in B-cells has been revived due to the description of new functions. Supporting a role for B-cells in the genesis of autoimmune diseases is the fact…”
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Recent Progress in the Understanding of B‐Cell Functions in Autoimmunity by Porakishvili, N., Mageed, R., Jamin, C., Pers, J.‐O., Kulikova, N., Renaudineau, Y., Lydyard, P. M., Youinou, P.

“…Our early concepts of the normal role of B cells in immunity focused on their ability to produce antibodies (Ab) and in the case of autoimmune diseases…”
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CD5-induced apoptosis of B cells in some patients with chronic lymphocytic leukemia by PERS, J. O, BERTHOU, C, PORAKISHVILI, N, BURDJANADZE, M, LE CALVEZ, G, ABGRALL, J. F, LYDYARD, P. M, YOUINOU, P, JAMIN, C

“…Although B chronic lymphocytic leukemia (B-CLL) is characterized by prolonged survival of CD5(+) B cells in vivo, these cells apoptose spontaneously in vitro…”
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Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis by Ruiz-Limon, Patricia, Ortega-Castro, Rafaela, Barbarroja, Nuria, Perez-Sanchez, Carlos, Jamin, Christophe, Patiño-Trives, Alejandra Maria, Luque-Tevar, Maria, Ibáñez-Costa, Alejandro, Perez-Sanchez, Laura, de la Rosa, Iván Arias, Abalos-Aguilera, MaCarmen, Jimenez-Gomez, Yolanda, Calvo-Gutierrez, Jerusalem, Font, Pilar, Escudero-Contreras, Alejandro, Alarcon-Riquelme, Marta E, Collantes-Estevez, Eduardo, López-Pedrera, Chary

“…This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the…”
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BAFF Overexpression Is Associated with Autoantibody Production in Autoimmune Diseases by PERS, JACQUES-OLIVIER, DARIDON, CAPUCINE, DEVAUCHELLE, VALÉRIE, JOUSSE, SANDRINE, SARAUX, ALAIN, JAMIN, CHRISTOPHE, YOUINOU, PIERRE

“…: The B‐cell activity factor (BAFF) acts as a positive regulator of B‐cell function. To gain further insight into the understanding of B‐cell hyperactivity in…”
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B lymphocytes in nonorgan-specific autoimmune diseases: implications for therapy by Youinou, P, Pers, J-O

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Effects of rituximab therapy on quality of life in patients with primary Sjögren's syndrome by DEVAUCHELLE-PENSEC, V, MORVAN, J, YOUINOU, P, SARAUX, A, RAT, A. C, JOUSSE-JOULIN, S, PENNEC, Y, PERS, J. O, JAMIN, C, RENAUDINEAU, Y, QUINTIN ROUE, I, COCHENER, B

“…To assess the efficacy of the anti-CD20 antibody rituximab in improving physical function and health-related quality of life (HRQoL) in patients with active…”
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Ligation of CD5 on resting B cells, but not on resting T cells, results in apoptosis by Pers, Jacques‐Olivier, Jamin, Christophe, Corre, Rozenn Le, Lydyard, Peter M., Youinou, Pierre

“…The CD5 molecule is expressed by a B cell subset. We have demonstrated that resting B cells do not proliferate in response to CD5 ligation, whereas cells…”
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Absence of up-regulation for a proliferation-inducing ligand in Sjögren's sialadenitis lesions by Lombardi, Tommaso, Moll, Solange, Youinou, Pierre, Pers, Jacques-Olivier, Tzankov, Alexander, Gabay, Cem, Santiago-Raber, Marie-Laure, Chizzolini, Carlo, Huard, Bertrand

“…Objective. To determine whether a proliferation-inducing ligand (APRIL) has a role in the survival of plasma cells infiltrating salivary glands from SS…”
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Differential effects of anti-FcγRIIIb autoantibodies on polymorphonuclear neutrophil apoptosis and function by Durand, Véronique, Pers, Jacques‐Olivier, Renaudineau, Yves, Saraux, Alain, Youinou, Pierre, Jamin, Christophe

“…Anti‐Fcγ receptor IIIb (FcγRIIIb) human autoantibodies (Ab) have been classified previously into three groups, based on the results of an indirect…”
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B Lymphocytes in Primary Sjögren’s Syndrome by Pers, J.-O, Youinou, P

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Updating the physiology, exploration and disease relevance of complement factor H by Buhé, V, Loisel, S, Pers, J O, Le Ster, K, Berthou, C, Youinou, P

“…The factor H (FH) protein (also known as beta1H globulin) is the main regulator of the complement alternative pathway. It exhibits multivalent binding sites to…”
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Practical usefulness of IgA-containing immune complex determination in the serum of patients with primary Sjögren's syndrome by Basset, C, Pers, J O, Youinou, P, Pennec, Y L

“…To evaluate the relevance of IgA-containing immune complexes (IC) as a predictor of lymphocytic infiltration of the minor salivary glands, and thus to…”
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