Search Results - "PERRY, V. H"

Systemic inflammation and disease progression in Alzheimer disease by HOLMES, C, CUNNINGHAM, C, ZOTOVA, E, WOOLFORD, J, DEAN, C, KERR, S, CULLIFORD, D, PERRY, V. H

“…Acute and chronic systemic inflammation are characterized by the systemic production of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha)…”
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Review: Activation patterns of microglia and their identification in the human brain by Boche, D., Perry, V. H., Nicoll, J. A. R.

“…Microglia in the central nervous system are usually maintained in a quiescent state. When activated, they can perform many diverse functions which may be…”
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Proinflammatory cytokines, sickness behavior, and Alzheimer disease by HOLMES, C, CUNNINGHAM, C, ZOTOVA, E, CULLIFORD, D, PERRY, V. H

“…In Alzheimer disease (AD), systemic inflammation is known to give rise to a delirium. However, systemic inflammation also gives rise to other centrally…”
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Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology by Carare, R. O., Bernardes-Silva, M., Newman, T. A., Page, A. M., Nicoll, J. A. R., Perry, V. H., Weller, R. O.

“…Elimination of interstitial fluid and solutes plays a role in homeostasis in the brain, but the pathways are unclear. Previous work suggests that interstitial…”
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Systemic infection, interleukin 1β, and cognitive decline in Alzheimer’s disease by Holmes, C, El-Okl, M, Williams, A L, Cunningham, C, Wilcockson, D, Perry, V H

“…Activated microglia, the resident macrophages of the brain, are a feature of Alzheimer’s disease. Animal models suggest that when activated microglia are…”
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Axonal damage in acute multiple sclerosis lesions by FERGUSON, B, MATYSZAK, M. K, ESIRI, M. M, PERRY, V. H

“…One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the…”
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Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease by Combrinck, M.I., Perry, V.H., Cunningham, C.

“…Peripheral infections in mammals are characterised by local, systemic and CNS effects. The latter give rise to sickness behaviour. Pro-inflammatory cytokines…”
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Mechanisms to explain the reverse perivascular transport of solutes out of the brain by Schley, D., Carare-Nnadi, R., Please, C.P., Perry, V.H., Weller, R.O.

“…Experimental studies and observations in the human brain indicate that interstitial fluid and solutes, such as amyloid- β ( A β ) , are eliminated from grey…”
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Focal Lesions in the Rat Central Nervous System Induced by Endothelin-1 by HUGHES, P M, ANTHONY, D C, RUDDIN, M, BOTHAM, M S, RANKINE, E L, SABLONE, M, BAUMANN, D, MIR, A K, PERRY, V H

“…Axon injury following cerebral ischemia has received little scientific attention compared to the abundance of information dealing with the pathophysiology of…”
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Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease by Cunningham, C., Deacon, R., Wells, H., Boche, D., Waters, S., Diniz, C. Picanco, Scott, H., Rawlins, J. N. P., Perry, V. H.

“…Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by amyloid deposition, astrogliosis, microglial activation, tissue…”
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Cytokine-induced Acute Inflammation in the Brain and Spinal Cord by Schnell, L, Fearn, S, Schwab, M E, Perry, V H, Anthony, D C

“…Different compartments in the central nervous system mount distinct inflammatory responses. The meninges and choroid plexus respond to pro-inflammatory stimuli…”
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T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases by Newman, T. A., Woolley, S. T., Hughes, P. M., Sibson, N. R., Anthony, D. C., Perry, V. H.

“…Recent evidence has highlighted the fact that axon injury is an important component of multiple sclerosis pathology. The issue of whether a CNS…”
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Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines by Teeling, J.L, Felton, L.M, Deacon, R.M.J, Cunningham, C, Rawlins, J.N.P, Perry, V.H

“…Abstract Systemic inflammation impacts on the brain and gives rise to behavioral changes, often referred to as ‘sickness behavior’. These symptoms are thought…”
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Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury by Gomes-Leal, W., Corkill, D.J., Freire, M.A.M., Picanço-Diniz, C.W., Perry, V.H.

“…Glial activation and degeneration are important outcomes in the pathophysiology of acute brain and spinal cord injury (SCI). Our main goal was to investigate…”
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Age-related effects of interleukin-1β on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats by ANTHONY, D. C, BOLTON, S. J, FEARN, S, PERRY, V. H

“…In adult rats, 50,000 units of recombinant interleukin-1 beta (IL-1 beta) injected into the brain parenchyma produced an intense meningitis and disruption of…”
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The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system by Matyszak, M.K, Perry, V.H

“…Dendritic cells of the rat were studied immunohistochemically with MRC OX62 monoclonal antibody and using electron microscopy. In normal CNS, a small number of…”
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Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy by Stuckey, D. J., Anthony, D. C., Lowe, J. P., Miller, J., Palm, W. M., Styles, P., Perry, V. H., Blamire, A. M., Sibson, N. R.

“…Macrophages are key components of the inflammatory response to tissue injury, but their activities can exacerbate neuropathology. High‐resolution magnetic…”
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Interleukin-1β-Induced Changes in Blood–Brain Barrier Permeability, Apparent Diffusion Coefficient, and Cerebral Blood Volume in the Rat Brain: A Magnetic Resonance Study by Blamire, A. M., Anthony, D. C., Rajagopalan, B., Sibson, N. R., Perry, V. H., Styles, P.

“…The cytokine interleukin-1β (IL-1β) is implicated in a broad spectrum of CNS pathologies, in which it is thought to exacerbate neuronal loss. Here, the effects…”
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Turnover of resident microglia in the normal adult mouse brain by Lawson, L J, Perry, V H, Gordon, S

“…We undertook this study to determine whether the microglia, the resident macrophages of the central nervous system, turn over in the steady-state. The turnover…”
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Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms by Teeling, J.L, Perry, V.H

“…Abstract We have all at some time experienced the non-specific symptoms that arise from being ill following a systemic infection. These symptoms, such as…”
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