Search Results - "PERRIN, Charles L."

Symmetry of Hydrogen Bonds: Application of NMR Method of Isotopic Perturbation and Relevance of Solvatomers by Perrin, Charles L

“…Short, strong, symmetric, low-barrier hydrogen bonds (H-bonds) are thought to be of special significance. We have been searching for symmetric H-bonds by using…”
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Symmetry of hydrogen bonds in solution by Perrin, Charles L.

“…A classic question regarding hydrogen bonds (H-bonds) concerns their symmetry. Is the hydrogen centered or is it closer to one donor and jumping between them?…”
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Protein-like proton exchange in a synthetic host cavity by Hart-Cooper, William M., Sgarlata, Carmelo, Perrin, Charles L., Toste, F. Dean, Bergman, Robert G., Raymond, Kenneth N.

“…The mechanism of proton exchange in ametal–ligand enzyme active site mimic (compound 1) is described through amide hydrogen–deuterium exchange kinetics. The…”
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Are Short, Low-Barrier Hydrogen Bonds Unusually Strong? by Perrin, Charles L

“…In a symmetric hydrogen bond (H-bond), the hydrogen atom is perfectly centered between the two donor atoms. The energy diagram for hydrogen motion is thus a…”
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Selectivity and Isotope Effects in Hydronation of a Naked Aryl Anion by Perrin, Charles L, Reyes-Rodríguez, Gabriel J

“…An aryl anion is produced by rapid addition of iodide to the p-benzyne diradical formed by cycloaromatization of an enediyne. The aryl anion is then hydronated…”
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On the Intramolecular Hydrogen Bond in Solution: Car–Parrinello and Path Integral Molecular Dynamics Perspective by Dopieralski, Przemyslaw, Perrin, Charles L, Latajka, Zdzislaw

“…The issue of the symmetry of short, low-barrier hydrogen bonds in solution is addressed here with advanced ab initio simulations of a hydrogen maleate anion in…”
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Secondary Deuterium Isotope Effects on the Acidity of Carboxylic Acids and Phenols by Perrin, Charles L, Dong, Yanmei

“…Secondary deuterium isotope effects (IEs) on acidities have been accurately measured by an NMR titration method applicable to a mixture of isotopologues…”
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Linear or Nonlinear Least-Squares Analysis of Kinetic Data? by Perrin, Charles L

“…The disadvantages of the usual linear least-squares analysis of first- and second-order kinetic data are described, and nonlinear least-squares fitting is…”
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ipso by Perrin, Charles L

“…On a substituted benzene ring the position that bears the substituent is designated as the ipso position. This Perspective presents the history behind that…”
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Malonic Anhydrides, Challenges from a Simple Structure by Perrin, Charles L.

“…After many years of unsuccessful attempts, monomeric malonic anhydrides were prepared by ozonolysis of ketene dimers, a procedure validated by model studies…”
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My first publication by Perrin, Charles L.

“…An undergraduate lab course in the physics department was what led me to a 50+ ‐year career in physical organic chemistry, solving a wide range of puzzles…”
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The Complete Mechanism of an Aldol Condensation by Perrin, Charles L, Chang, Kuei-Lin

“…Although aldol condensation is one of the most important organic reactions, capable of forming new C–C bonds, its mechanism has never been fully established…”
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Cyclohexeno[3,4]cyclodec-1,5-diyne-3-ene: A Convenient Enediyne by Shrinidhi, Annadka, Perrin, Charles L

“…Enediynes are widely studied to understand their cycloaromatization and the trapping of the resulting p-dehydrobenzene diradical. However, few model substrates…”
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Symmetry of Hydrogen Bonds in Two Enols in Solution by Perrin, Charles L, Wu, Yifan

“…The enols of 4-cyano-2,2,6,6-tetramethyl-3,5-heptanedione and of nitromalonamide were prepared as statistical mixtures of 18O n (n = 0, 1, 2) isotopologues…”
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The Logic behind a Physical–Organic Chemist’s Research Topics by Perrin, Charles L

“…Although my research has no common theme or defining area, a coherence connects the diverse topics insofar as one project leads logically to another. Thus,…”
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Reactivity of nucleophiles toward a p-benzyne derived from an enediyne by Perrin, Charles L., Reyes-Rodríguez, Gabriel J.

“…Enediynes undergo cycloaromatization to p‐benzyne diradicals. A new reaction of p‐benzynes is here presented. Instead of their usual radical reactivity, they…”
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Enthalpic and entropic contributions to the basicity of cycloalkylamines by Perrin, Charles L, Shrinidhi, Annadka

“…Large-ring cycloalkylamines are slightly less basic than other cycloalkylamines such as cyclohexylamine, even though all have tetrahedral carbons and are…”
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pH-Free Measurement of Relative Acidities, Including Isotope Effects by Perrin, Charles L

“…A powerful pH-free multicomponent NMR titration method can measure relative acidities, even of closely related compounds, with excellent accuracy. The history…”
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Isotopic-Perturbation NMR Study of Hydrogen-Bond Symmetry in Solution: Temperature Dependence and Comparison of OHO and ODO Hydrogen Bonds by Perrin, Charles L, Shrinidhi, Annadka, Burke, Kathryn D

“…Is a hydrogen bond symmetric, with the hydrogen centered between two donor atoms, or is it asymmetric, with the hydrogen closer to one but jumping to the…”
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Polynomial coefficients. Application to spin–spin splitting by N equivalent nuclei of spin I > 1/2 by Perrin, Charles L.

“…The NMR intensity pattern of a nucleus split by N identical nuclei of spin 1/2 is given by the binomial coefficients. These are conveniently obtained from…”
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