Search Results - "PERNA, ALESSANDRA F"
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Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic Toxins
Published in International journal of molecular sciences (01-03-2023)“…Chronic kidney disease (CKD) is an increasing health care problem. About 10% of the general population is affected by CKD, representing the sixth cause of…”
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Does gut microbiota dysbiosis impact the metabolic alterations of hydrogen sulfide and lanthionine in patients with chronic kidney disease?
Published in BMC microbiology (26-10-2024)“…Chronic Kidney Disease (CKD) is characterized by a methionine-related metabolic disorder involving reduced plasma levels of hydrogen sulfide (H S) and…”
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3
COVID-19, Low-Molecular-Weight Heparin, and Hemodialysis
Published in Kidney & blood pressure research (01-05-2020)“…According to another report, related to another university dialysis facility (Renmin Hospital) in Wuhan, China, in the period between January 14, 2020, when…”
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Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes
Published in Toxins (01-03-2023)“…Impaired polymorphonuclear leukocyte (PMNL) functions contribute to increased infections and cardiovascular diseases in chronic kidney disease (CKD). Uremic…”
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Impact of the uremic milieu on the osteogenic potential of mesenchymal stem cells
Published in PloS one (30-01-2015)“…Human mesenchymal stem cells (hMSCs), the precursors of osteoblasts during osteogenesis, play a role in the balance of bone formation and resorption, but their…”
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6
Therapeutic Plasmapheresis: A Revision of Literature
Published in Kidney & blood pressure research (01-01-2023)“…Abstract Background: Therapeutic plasmapheresis (TP) is an extracorporeal therapy that allows the removal of pathogens from plasma. The role of TP in…”
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Two Different Serum MiRNA Signatures Correlate with the Clinical Outcome and Histological Subtype in Pleural Malignant Mesothelioma Patients
Published in PloS one (11-08-2015)“…Pleural malignant mesothelioma (MPM) is a detrimental neoplasm affecting pleural sheets and determining a high rate of mortality. In this study, we have…”
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Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway
Published in Scientific reports (31-03-2020)“…Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a…”
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Homocysteine Solution-Induced Response in Aerosol Jet Printed OECTs by Means of Gold and Platinum Gate Electrodes
Published in International journal of molecular sciences (25-10-2021)“…Homocysteine (Hcy) is a non-protein, sulfur-containing amino acid, which is recognized as a possible risk factor for coronary artery and other pathologies when…”
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10
The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?
Published in Biology (Basel, Switzerland) (20-01-2023)“…Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy…”
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The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin
Published in Toxins (10-01-2017)“…Lanthionine is a nonproteinogenic amino acid, composed of two alanine residues that are crosslinked on their β-carbon atoms by a thioether linkage. It is…”
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Uremic Toxin Lanthionine Interferes with the Transsulfuration Pathway, Angiogenetic Signaling and Increases Intracellular Calcium
Published in International journal of molecular sciences (08-05-2019)“…(1) The beneficial effects of hydrogen sulfide (H S) on the cardiovascular and nervous system have recently been re-evaluated. It has been shown that…”
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13
Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine
Published in International journal of molecular sciences (29-04-2018)“…The non-proteinogenic amino acid lanthionine is a byproduct of hydrogen sulfide biosynthesis: the third endogenous vasodilator gas, after nitric oxide and…”
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14
Inflammation and Aortic Pulse Wave Velocity: A Multicenter Longitudinal Study in Patients With Inflammatory Bowel Disease
Published in Journal of the American Heart Association (05-02-2019)“…Background Inflammatory bowel disease ( IBD ) is characterized by a low prevalence of traditional risk factors, an increased aortic pulse-wave velocity ( aPWV…”
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Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed
Published in Journal of personalized medicine (11-05-2023)“…Thyroid cancers require complex and heterogeneous therapies with different impacts on renal function. In our systematic literature review, we analyzed several…”
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Lab on a Chip Device for Diagnostic Evaluation and Management in Chronic Renal Disease: A Change Promoting Approach in the Patients' Follow Up
Published in Biosensors (Basel) (01-03-2023)“…Lab-on-a-chip (LOC) systems are miniaturized devices aimed to perform one or several analyses, normally carried out in a laboratory setting, on a single chip…”
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Next-Generation Sequencing (NGS) Analysis Illustrates the Phenotypic Variability of Collagen Type IV Nephropathies
Published in Genes (21-03-2023)“…Mutations in cause a spectrum of glomerular disorders, including thin basement membrane nephropathy (TBMN) and Alport syndrome (AS). The wide application of…”
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A case series of adult patients affected by EAST/SeSAME syndrome suggests more severe disease in subjects bearing KCNJ10 truncating mutations
Published in Intractable & Rare Diseases Research (01-05-2021)“…EAST/SeSAME syndrome is a rare disease affecting the Central Nervous System (CNS), inner ear, and kidney. The syndrome is due to loss-of-function mutations in…”
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Uremic Toxin Lanthionine Induces Endothelial Cell Mineralization In Vitro
Published in Biomedicines (14-02-2022)“…Vascular calcification (VC) is a pathological event caused by the unusual deposition of minerals in the vascular system, representing the leading cause of…”
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Corrigendum: Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice
Published in Frontiers in physiology (29-11-2018)“…[This corrects the article DOI: 10.3389/fphys.2018.01273.]…”
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