Search Results - "PERMAR, Sallie"

chngpt: threshold regression model estimation and inference by Fong, Youyi, Huang, Ying, Gilbert, Peter B, Permar, Sallie R

“…Threshold regression models are a diverse set of non-regular regression models that all depend on change points or thresholds. They provide a simple but…”
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Routine SARS‐CoV‐2 vaccination for all children by De Paris, Kristina, Permar, Sallie R.

“…Summary The SARS‐CoV‐2 pandemic has resulted in unprecedented health and economic losses. Children generally present with less severe disease from this virus…”
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Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries by Otero, Claire E, Langel, Stephanie N, Blasi, Maria, Permar, Sallie R

“…Rotavirus (RV) vaccine efficacy is significantly reduced in lower- and middle-income countries (LMICs) compared to high-income countries. This review…”
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Derisking Human Cytomegalovirus Vaccine Clinical Development in Relevant Preclinical Models by Permar, Sallie R, Kaur, Amitinder, Fruh, Klaus

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Maternal immune protection against infectious diseases by Langel, Stephanie N, Blasi, Maria, Permar, Sallie R

“…The maternal immune system protects developing offspring against pathogens before birth via transplacental transfer and after birth through secreted milk. This…”
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Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health by Fries, Chelsea N., Curvino, Elizabeth J., Chen, Jui-Lin, Permar, Sallie R., Fouda, Genevieve G., Collier, Joel H.

“…Despite the overwhelming success of vaccines in preventing infectious diseases, there remain numerous globally devastating diseases without fully protective…”
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Progress toward Development of a Vaccine against Congenital Cytomegalovirus Infection by Schleiss, Mark R, Permar, Sallie R, Plotkin, Stanley A

“…A vaccine against congenital human cytomegalovirus (CMV) infection is a major public health priority. Congenital CMV causes substantial long-term morbidity,…”
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Protective mechanisms of nonneutralizing antiviral antibodies by Chandler, Tawny L, Yang, Agnes, Otero, Claire E, Permar, Sallie R, Caddy, Sarah L

“…Antibodies that can bind to viruses but are unable to block infection in cell culture are known as "nonneutralizing antibodies." Such antibodies are nearly…”
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COVID-19 Research Delays Disproportionately Affected Pediatrician-Scientists from Backgrounds Under-Represented in Medicine by Nelson, Adin, Lam, Janet, Permar, Sallie R, Abramson, Erika

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Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections by Permar, Sallie R, Schleiss, Mark R, Plotkin, Stanley A

“…Human cytomegalovirus (HCMV) is the most common congenitally transmitted pathogen worldwide, impacting an estimated 1 million newborns annually. Congenital…”
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Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome by Handley, Scott A., Thackray, Larissa B., Zhao, Guoyan, Presti, Rachel, Miller, Andrew D., Droit, Lindsay, Abbink, Peter, Maxfield, Lori F., Kambal, Amal, Duan, Erning, Stanley, Kelly, Kramer, Joshua, Macri, Sheila C., Permar, Sallie R., Schmitz, Joern E., Mansfield, Keith, Brenchley, Jason M., Veazey, Ronald S., Stappenbeck, Thaddeus S., Wang, David, Barouch, Dan H., Virgin, Herbert W.

“…Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate…”
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A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus by Jenks, Jennifer A, Amin, Sharmi, Sponholtz, Madeline R, Kumar, Amit, Wrapp, Daniel, Venkatayogi, Sravani, Tu, Joshua J, Karthigeyan, Krithika, Valencia, Sarah M, Connors, Megan, Harnois, Melissa J, Hora, Bhavna, Rochat, Eric, McLellan, Jason S, Wiehe, Kevin, Permar, Sallie R

“…Cytomegalovirus (CMV) is a leading cause of infant hearing loss and neurodevelopmental delay, but there are no clinically licensed vaccines to prevent…”
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Children are the key to the Endgame: A case for routine pediatric COVID vaccination by Schleiss, Mark R., John, Chandy C., Permar, Sallie R.

“…The situation will only worsen as students go back to the classroom this fall. Since the pandemic began, children have accounted for ~14.0% of total cumulated…”
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Leveraging preclinical study designs to close gaps in vaccine development for perinatal pathogens by Crooks, Chelsea M, Chan, Cliburn, Permar, Sallie R

“…Vaccines to perinatal pathogens are critical for both reducing the burden of endemic pathogens and preparing for the next pandemic. Although they are often at…”
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Human Cytomegalovirus Infection Primes Fetal Natural Killer Cells for Fc-Mediated Antiviral Defense by Semmes, Eleanor C, Permar, Sallie R

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The March towards a Vaccine for Congenital CMV: Rationale and Models by Bialas, Kristy M, Permar, Sallie R

“…  [...]defining the CMV immunogens which elicit the most robust protective immune responses and block infection of both fibroblast and epithelial cell types is…”
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Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection by Langel, Stephanie N, Otero, Claire E, Martinez, David R, Permar, Sallie R

“…About the Authors: Stephanie N. Langel * E-mail: stephanie.langel@duke.edu (SNL); sallie.permar@duke.edu (SRR) Affiliations Duke Human Vaccine Institute, Duke…”
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Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface by Yang, Liheng, Semmes, Eleanor C, Ovies, Cristian, Megli, Christina, Permar, Sallie, Gilner, Jennifer B, Coyne, Carolyn B

“…Infections at the maternal-fetal interface can directly harm the fetus and induce complications that adversely impact pregnancy outcomes. Innate immune…”
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HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions by Nelson, Cody S., Huffman, Tori, Jenks, Jennifer A., de la Rosa, Eduardo Cisneros, Xie, Guanhua, Vandergrift, Nathan, Pass, Robert F., Pollara, Justin, Permar, Sallie R.

“…Human cytomegalovirus (HCMV) is the most common congenital infection worldwide, frequently causing hearing loss and brain damage in afflicted infants. A…”
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Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques by Ram, Daniel R, Manickam, Cordelia, Hueber, Brady, Itell, Hannah L, Permar, Sallie R, Varner, Valerie, Reeves, R Keith

“…Natural killer (NK) cells classically typify the nonspecific effector arm of the innate immune system, but have recently been shown to possess memory-like…”
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