Search Results - "PERLEE, Lorah"

Environmental exposure unit simulates natural seasonal birch pollen exposures while maximizing change in allergic symptoms by Ellis, Anne K., DeVeaux, Michelle, Steacy, Lisa, Ramesh, Divya, Suprun, Maria, Langdon, Shaun, Wang, Claire Q., Adams, Daniel, Thiele, Jenny, Walker, Terry, Perlee, Lorah T., O'Brien, Meagan P.

“…Birch pollen is a prevalent aeroallergen during the springtime allergy season. In field studies, variable allergen exposure and environmental factors can…”
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Risk Alleles Associated with Neovascularization in a Pachychoroid Phenotype by Dansingani, Kunal K., MA, FRCOphth, Perlee, Lorah T., PhD, Hamon, Sara, PhD, Lee, May, MST, Shah, Vinnie P., MD, Spaide, Richard F., MD, Sorenson, John, MD, Klancnik, James M., MD, Yannuzzi, Lawrence A., MD, Barbazetto, Irene A., MD, Cooney, Michael J., MD, MBA, Engelbert, Michael, MD, PhD, Chen, Christine, PhD, FRANZCO, Hewitt, Alex W., PhD, FRANZCO, Freund, K. Bailey, MD

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Pozelimab for CHAPLE disease: results from in-trial interviews and clinical outcome assessments by Litcher-Kelly, Leighann, Ozen, Ahmet, Ollis, Sarah, Feldman, Hagit Baris, Yaworsky, Andrew, Medrano, Paolo, Chongsrisawa, Voranush, Brackin, Taylor, Perlee, Lorah, Walker, Marisa, Pradeep, Sharanya, Lenardo, Michael J, Harari, Olivier A, Jalbert, Jessica J

“…CD55 deficiency with hyper-activation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) disease is ultra-rare (< 100 children or…”
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Inclusion of Genotype with Fundus Phenotype Improves Accuracy of Predicting Choroidal Neovascularization and Geographic Atrophy by Perlee, Lorah T., PhD, Bansal, Aruna T., PhD, Gehrs, Karen, MD, Heier, Jeffrey S., MD, Csaky, Karl, MD, Allikmets, Rando, PhD, Oeth, Paul, MS, Paladino, Toni, PhD, Farkas, Daniel H., PhD, Rawlings, P. Lyle, BS, Hageman, Gregory S., PhD

“…Purpose The accuracy of predicting conversion from early-stage age-related macular degeneration (AMD) to the advanced stages of choroidal neovascularization…”
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Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration by Hageman, Gregory S, Gehrs, Karen, Lejnine, Serguei, Bansal, Aruna T, Deangelis, Margaret M, Guymer, Robyn H, Baird, Paul N, Allikmets, Rando, Deciu, Cosmin, Oeth, Paul, Perlee, Lorah T

“…Predictive tests for estimating the risk of developing late-stage neovascular age-related macular degeneration (AMD) are subject to unique challenges. AMD…”
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P797: A PHASE 2, OPEN‐LABEL STUDY EVALUATING THE SAFETY AND EFFICACY OF COMBINATION POZELIMAB AND CEMDISIRAN THERAPY IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA WHO SWITCH FROM ECULIZUMAB by Kelly, Richard, Houghton, Nicola, Munir, Talha, Muus, Petra, Youngs, Nora, Aurand, Lisa, Senk, Brian, Pavani, Rodrigo, Perlee, Lorah, Souttou, Amal, Griffin, Morag

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P782: A PHASE 2, RANDOMIZED TRIAL EVALUATING THE SAFETY AND EFFICACY OF POZELIMAB AND CEMDISIRAN IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA by Jang, Jun‐Ho, Wong, Raymond, Pavani, Rodrigo, Aurand, Lisa, Nguyen, Quang P., Perlee, Lorah, Souttou, Amal, Weyne, Jonathan, Kelly, Richard

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Cellular and tissue localization of globotriaosylceramide in Fabry disease by ASKARI, Hasan, KANESKI, Christine R, SCHIFFMANN, Raphael, SEMINO-MORA, Cristina, DESAI, Priya, ANG, Agnes, KLEINER, David E, PERLEE, Lorah T, QUEZADO, Martha, SPOLLEN, Linda E, WUSTMAN, Brandon A

“…The pathogenesis of Fabry disease is poorly understood. We used a variety of immunohistological techniques to localize globotriaosylceramide, the main…”
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Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report by Lee, Jean W, Weiner, Russ S, Sailstad, Jeff M, Bowsher, Ronald R, Knuth, Dean W, O'Brien, Peter J, Fourcroy, Jean L, Dixit, Rakesh, Pandite, Lini, Pietrusko, Robert G, Soares, Holly D, Quarmby, Valerie, Vesterqvist, Ole L, Potter, David M, Witliff, James L, Fritche, Herbert A, O'Leary, Timothy, Perlee, Lorah, Kadam, Sunil, Wagner, John A

“…Biomarkers are increasingly used in drug development to aid scientific and clinical decisions regarding the progress of candidate and marketed therapeutics…”
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Identification of Diagnostic Biomarkers for Infection in Premature Neonates by Kingsmore, Stephen F., Kennedy, Neil, Halliday, Henry L., Van Velkinburgh, Jennifer C., Zhong, Shengiang, Gabriel, Vanessa, Grant, Judith, Beavis, William D., Tchernev, Velizar T., Perlee, Lorah, Lejnine, Serguei, Grimwade, Brian, Sorette, Martin, Edgar, J. David M.

“…Infection is a leading cause of neonatal morbidity and mortality worldwide. Premature neonates are particularly susceptible to infection because of physiologic…”
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A Phase 2, Randomized Trial Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran in Patients with Paroxysmal Nocturnal Hemoglobinuria by Jang, Jun Ho, Wong, Raymond, Pavani, Rodrigo, Aurand, Lisa, Dain, Bradley, Perlee, Lorah, Souttou, Amal, Weyne, Jonathan, Kelly, Richard

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52-Week Open-Label Extension Data from a Phase 2 Study Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switched from Eculizumab by Kelly, Richard J., Houghton, Nicola, Munir, Talha, Muus, Petra, Youngs, Nora, Aurand, Lisa, Mohan, Kosalai, Senk, Brian, Pavani, Rodrigo, Perlee, Lorah, Souttou, Amal, Griffin, Morag

“…Background: Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare, acquired disorder, leading to impaired expression of complement-regulating proteins on…”
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A Single Dose Of Fel d 1 Monoclonal Antibodies Regulates Molecular Signatures of Asthma In Nasal Mucosa Upon Cat Allergen Challenge In A Phase 2 Study by OBrien, Meagan, Gayvert, Kaitlyn, Wipperman, Matthew, de Blay, Fredreic, GHERASIM, Alina, Domis, Nathalie, Meier, Pretty, DeVeaux, Michelle, Perlee, Lorah, Herman, Gary, Lim, Wei Keat, Hamilton, Jennifer, Hamon, Sara

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Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study by Gevaert, Philippe, De Craemer, Jarno, De Ruyck, Natalie, Rottey, Sylvie, de Hoon, Jan, Hellings, Peter W., Volckaert, Bram, Lesneuck, Kristof, Orengo, Jamie M., Atanasio, Amanda, Kamal, Mohamed A., Abdallah, Hisham, Kamat, Vishal, Dingman, Robert, DeVeaux, Michelle, Ramesh, Divya, Perlee, Lorah, Wang, Claire Q., Weinreich, David M., Herman, Gary, Yancopoulos, George D., O’Brien, Meagan P.

“…The efficacy of an allergen-specific IgG cocktail to treat cat allergy suggests that allergen-specific IgG may be a major protective mechanism elicited by…”
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Evaluation of Common Gamma Chain Cytokine Signaling Blockade with REGN7257, an Interleukin 2 Receptor Gamma (IL2RG) Monoclonal Antibody, on Immune Cell Populations in Monkey and Human by Le Floch-Ramondou, Audrey, Nagashima, Kirsten, Gayvert, Kaitlyn, Pan, Hao, Korgaonkar, Chandrashekhar, Shakil, Hassan, Ullman, Erica, Norton, Thomas, Perlee, Lorah, Murphy, Andrew J., Sleeman, Matthew, Orengo, Jamie

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A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of Combination Pozelimab and Cemdisiran Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switch from Eculizumab by Kelly, Richard, Houghton, Nicola, Munir, Talha, Muus, Petra, Youngs, Nora, Aurand, Lisa, Dain, Bradley, Pavani, Rodrigo, Perlee, Lorah, Souttou, Amal, Griffin, Morag

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Blockade of Common Gamma Chain Cytokine Signaling with REGN7257, an Interleukin 2 Receptor Gamma (IL2RG) Monoclonal Antibody, Protected Mice from Inflammatory and Autoimmune Diseases by Le Floch-Ramondou, Audrey, Nagashima, Kirsten, Farrales, Pamela, Tay, Amanda, Herbin, Olivier, Ajithdoss, Dharani, Norton, Thomas, Perlee, Lorah, Murphy, Andrew J., Sleeman, Matthew, Orengo, Jamie

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Single Ascending Doses of REGN7999, a Monoclonal Antibody Inhibitor of TMPRSS6, Increase Serum Hepcidin and Cause Deep, Sustained Reductions in Serum Iron in Healthy Human Volunteers by Rottey, Sylvie, Singh, Nikhil, Labriola-Tompkins, Emily, Lob, Heinrich E, Mohammadi, Kusha, Hassan, Hazem, Farrelly, Lorna, Duggal, Swati, Chin, Harvey, Hatsell, Sarah, Burczynski, Michael E., Harari, Olivier, Perlee, Lorah, Van Lancker, Griet

“…Background: Iron overload (IOL) develops in dyserythropoieses such as beta-thalassemia and myelodysplastic syndromes due both to red blood cell transfusions as…”
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REGN1908/1909 prevented cat allergen–induced early asthmatic responses in an environmental exposure unit by de Blay, Frederic J., Gherasim, Alina, Domis, Nathalie, Meier, Pretty, Shawki, Furat, Wang, Claire Q., Orengo, Jamie M., DeVeaux, Michelle, Ramesh, Divya, Jalbert, Jessica J., Kamal, Mohamed A., Abdallah, Hisham, Dingman, Robert, Perlee, Lorah, Weinreich, David.M., Herman, Gary, Yancopoulos, George D., O’Brien, Meagan P.

“…The dominant allergen in cat dander, Felis domesticus allergen 1 (Fel d 1), is a persistent trigger for allergic rhinitis and asthma symptoms. We evaluated the…”
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INTRAVITREAL NESVACUMAB (ANTIANGIOPOIETIN 2) PLUS AFLIBERCEPT IN DIABETIC MACULAR EDEMA: Phase 2 RUBY Randomized Trial by Brown, David M., Boyer, David S., Csaky, Karl, Vitti, Robert, Perlee, Lorah, Chu, Karen W., Asmus, Friedrich, Leal, Sergio, Zeitz, Oliver, Cheng, Yenchieh, Schmelter, Thomas, Heier, Jeffrey S.

“…The purpose of this study was to compare intravitreal nesvacumab (anti-angiopoietin 2) plus aflibercept with intravitreal aflibercept injection (IAI) in…”
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