Search Results - "PERKINS, MICHAEL"

3-Methoxy-2-phenylimidazo[1,2-b]pyridazines highly active against Mycobacterium tuberculosis and Mycobacterium marinum by Farrell, Kyle D., Gao, Yamin, Hughes, Deborah A., Henches, Robin, Tu, Zhengchao, Perkins, Michael V., Zhang, Tianyu, Francis, Craig L.

“…A series of 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivatives which were highly active against autoluminescent Mycobacterium tuberculosis (Mtb) and…”
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Electrochemical Synthesis of Poly(trisulfides) by Pople, Jasmine M. M., Nicholls, Thomas P., Pham, Le Nhan, Bloch, Witold M., Lisboa, Lynn S., Perkins, Michael V., Gibson, Christopher T., Coote, Michelle L., Jia, Zhongfan, Chalker, Justin M.

“…With increasing interest in high sulfur content polymers, there is a need to develop new methods for their synthesis that feature improved safety and control…”
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Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges by Norris, Matthew D, Perkins, Michael V

“…Covering: up to early 2016Marine sponges are widely known as a rich source of natural products, especially of polyketide origin, with a wealth of chemical…”
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Proteome‐Wide Survey of Cysteine Oxidation by Using a Norbornene Probe by Alcock, Lisa J., Langini, Maike, Stühler, Kai, Remke, Marc, Perkins, Michael V., Bernardes, Gonçalo J. L., Chalker, Justin M.

“…Rapid detection of cysteine oxidation in living cells is critical in advancing our understanding of responses to reactive oxygen species (ROS) and oxidative…”
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Recent advances in DDAH1 inhibitor design and discovery: insights from structure-activity relationships and X-ray crystal structures by Doman, Anthony J, Perkins, Michael V, Tommasi, Sara, Mangoni, Arduino A, Nair, Pramod C

“…Nitric oxide (NO) is an important signalling molecule which modulates several biological and pathological processes. Dimethylarginine dimethylaminohydrolase 1…”
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New marine natural products from sponges (Porifera) of the order Dictyoceratida (2001 to 2012); a promising source for drug discovery, exploration and future prospects by Mehbub, Mohammad F, Perkins, Michael V, Zhang, Wei, Franco, Christopher M M

“…The discovery of new drugs can no longer rely primarily on terrestrial resources, as they have been heavily exploited for over a century. During the last few…”
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Integrative taxonomy reveals two new narrowly-endemic crayfish species (Decapoda: Cambaridae) from the Yadkin River Basin in western North Carolina, USA by Perkins, Michael A, Williams, Bronwyn W, Russ, William T

“…Two new species of stream-dwelling crayfish, Cambarus lapidosus, the Stony Fork Crayfish, and Cambarus burchfielae, the Falls Crayfish, are described from the…”
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Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway by Doman, Anthony J., Tommasi, Sara, Perkins, Michael V., McKinnon, Ross A., Mangoni, Arduino A., Nair, Pramod C.

“…[Display omitted] Nitric oxide (NO) is a signalling molecule that controls a multitude of regulatory functions including neurotransmission, vascular tone,…”
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Reaction of [ 18 F]Fluoride at Heteroatoms and Metals for Imaging of Peptides and Proteins by Positron Emission Tomography by Scroggie, Kymberley R, Perkins, Michael V, Chalker, Justin M

“…The ability to radiolabel proteins with [ F]fluoride enables the use of positron emission tomography (PET) for the early detection, staging and diagnosis of…”
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Phosphine toxicity: a story of disrupted mitochondrial metabolism by Sciuto, Alfred M., Wong, Benjamin J., Martens, Margaret E., Hoard-Fruchey, Heidi, Perkins, Michael W.

“…Rodenticides and pesticides pose a significant threat not only to the environment but also directly to humans by way of accidental and/or intentional exposure…”
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Neogene fallout tuffs from the Yellowstone hotspot in the Columbia Plateau region, Oregon, Washington and Idaho, USA by Nash, Barbara P, Perkins, Michael E

“…Sedimentary sequences in the Columbia Plateau region of the Pacific Northwest ranging in age from 16-4 Ma contain fallout tuffs whose origins lie in volcanic…”
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Synthesis and Characterization of Novel Anchorlipids for Tethered Bilayer Lipid Membranes by Andersson, Jakob, Knobloch, Jacqueline J, Perkins, Michael V, Holt, Stephen A, Köper, Ingo

“…Tethered bilayer lipid membranes are versatile solid-supported model membrane systems. Core to these systems is an anchorlipid that covalently links a lipid…”
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Total Synthesis of Plakilactones C, B and des-Hydroxyplakilactone B by the Oxidative Cleavage of Gracilioether Furanylidenes by Norris, Matthew D., Perkins, Michael V.

“…A chemoselective oxidative cleavage of synthetic gracilioether B, 11-epi-gracilioether C benzoate, and des-hydroxy­gracilioether C with pyridinium…”
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A biomimetic cascade for the formation of the methyl [2(5H)-furanylidene]ethanoate core of spongosoritin A and the gracilioethers by Norris, Matthew D., Perkins, Michael V.

“…The polyketide secondary metabolites spongosoritin A and gracilioethers A–C contain a unique methyl [2(5H)-furanylidene]ethanoate core. A synthetic model of a…”
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Leading public service reform: Some reflections by Watt, Robert, Perkins, Michael

“…The past decade has been a period of intense reform, bookended by two crises of seismic proportions – the troika bailout of Ireland in 2010 and the Covid-19…”
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A methyltransferase essential for the methoxypyrazine‐derived flavour of wine by Dunlevy, Jake D., Dennis, Eric G., Soole, Kathleen L., Perkins, Michael V., Davies, Christopher, Boss, Paul K.

“…Summary Methoxypyrazines are a family of potent volatile compounds of diverse biological significance. They are used by insects and plants in chemical defence,…”
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Effects of inhaled aerosolized carfentanil on real-time physiological responses in mice: a preliminary evaluation of naloxone by Wong, Benjamin, Perkins, Michael W., Tressler, Justin, Rodriguez, Ashley, Devorak, Jennifer, Sciuto, Alfred M.

“…This study examined the real-time exposure-response effects of aerosolized carfentanil (CRF) on opioid-induced toxicity, respiratory dynamics and cardiac…”
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Hidden in the hills: phylogeny of the freshwater mussel genus Alasmidonta (Bivalvia: Unionidae) and description of a new species by Whelan, Nathan V, Johnson, Nathan A, Williams, Ashantye’ S, Perkins, Michael A, Beaver, Caitlin E, Mays, Jason W

“…Abstract Inaccurate taxonomy can lead to species in need of conservation being overlooked, which makes revisionary systematics crucially important for…”
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Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells by Alcock, Lisa J, Oliveira, Bruno L, Deery, Michael J, Pukala, Tara L, Perkins, Michael V, Bernardes, Gonçalo J. L, Chalker, Justin M

“…Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is…”
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A Comparative Analysis of Catheter Directed Thrombolysis with Anticoagulation Alone or Systemic tPA in Acute Pulmonary Embolism with Cor Pulmonale by Krishnan, Anand Muthu, Gadela, Naga Vaishnavi, Ramanathan, Rudra, Jha, Anil, Perkins, Michael E., Metersky, Mark L.

“…Background Pulmonary embolism (PE) with cor pulmonale causes considerable mortality and morbidity. Randomized trials have failed to show a mortality difference…”
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