Search Results - "PERKINS, D. O"

Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics by McClay, J L, Adkins, D E, Åberg, K, Stroup, S, Perkins, D O, Vladimirov, V I, Lieberman, J A, Sullivan, P F, van den Oord, E J C G

“…Schizophrenia is an often devastating neuropsychiatric illness. Understanding the genetic variation affecting response to antipsychotics is important to…”
Get full text

Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors by Leserman, J, Petitto, J M, Gu, H, Gaynes, B N, Barroso, J, Golden, R N, Perkins, D O, Folds, J D, Evans, D L

“…The primary aim of this study is to examine prospectively the association of stressful life events, social support, depressive symptoms, anger, serum cortisol…”
Get more information

Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia by PERKINS, D. O, JEFFRIES, C, SULLIVAN, P

“…It is now evident that nonprotein coding RNA (ncRNA) plays a critical role in regulating the timing and rate of protein translation. The potential importance…”
Get full text

The Effects of Atypical Antipsychotic Drugs on Neurocognitive Impairment in Schizophrenia: A Review and Meta-analysis by Keefe, Richard S. E., Silva, Susan G., Perkins, Diana O., Lieberman, Jeffrey A.

“…Cognitive deficits are a fundamental feature of the psychopathology of schizophrenia. Yet the effect of treatment on this dimension of the illness has been…”
Get full text

Substance use in individuals at clinical high risk of psychosis by Buchy, L, Cadenhead, K S, Cannon, T D, Cornblatt, B A, McGlashan, T H, Perkins, D O, Seidman, L J, Tsuang, M T, Walker, E F, Woods, S W, Heinssen, R, Bearden, C E, Mathalon, D, Addington, J

“…A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of…”
Get more information

Neurocognitive predictors of metacognition in individuals at clinical high risk for psychosis by Shakeel, M K, Lu, L, Woods, S W, Perkins, D O, Addington, J

“…Metacognition refers to the ability to evaluate and control our cognitive processes. While studies have investigated metacognition in schizophrenia and…”
Get more information

Relationship of low vitamin D status with positive, negative and cognitive symptom domains in people with first-episode schizophrenia by Graham, K.A., Keefe, R.S., Lieberman, J.A., Calikoglu, A.S., Lansing, K.M., Perkins, D.O.

“…Aim Deficient vitamin D levels are very common among Americans of all ages and ethnicities, but little is known about its prevalence or associated problems…”
Get full text

Neuropsychological status of subjects at high risk for a first episode of psychosis by Hawkins, K.A., Addington, J., Keefe, R.S.E., Christensen, B., Perkins, D.O., Zipurksy, R., Woods, S.W., Miller, T.J., Marquez, E., Breier, A., McGlashan, T.H.

“…Thirty-six subjects aged 16 years or older judged at risk for a first episode of psychosis within a North American multi-site study of the schizophrenia…”
Get full text

The Early Psychosis Screener (EPS): Item development and qualitative validation by Brodey, B.B., Addington, J., First, M.B., Perkins, D.O., Woods, S.W., Walker, E.F., Walsh, B., Nieri, J.M., Nunn, M.B., Putz, J., Brodey, I.S.

“…A panel of experts assembled and analyzed a comprehensive item bank from which a highly sensitive and specific early psychosis screener could be developed…”
Get full text

The Early Psychosis Screener (EPS): Quantitative validation against the SIPS using machine learning by Brodey, B.B., Girgis, R.R., Favorov, O.V., Addington, J., Perkins, D.O., Bearden, C.E., Woods, S.W., Walker, E.F., Cornblatt, B.A., Brucato, G., Walsh, B., Elkin, K.A., Brodey, I.S.

“…Machine learning techniques were used to identify highly informative early psychosis self-report items and to validate an early psychosis screener (EPS)…”
Get full text

Longitudinal changes in social cognition in individuals at clinical high risk for psychosis: An outcome based analysis by Shakeel, M.K., Lu, L., Cannon, T.D., Cadenhead, K.S., Cornblatt, B.A., McGlashan, T.H., Perkins, D.O., Seidman, L.J., Tsuang, M.T., Woods, S.W., Walker, E.F., Mathalon, D.H., Bearden, C.E., Addington, J.

“…Social cognition deficits have been observed in individuals at clinical high risk (CHR) for psychosis. Longitudinal change in social cognition were analyzed in…”
Get full text

Olanzapine and haloperidol in first episode psychosis: Two-year data by Green, A.I., Lieberman, J.A., Hamer, R.M., Glick, I.D., Gur, R.E., Kahn, R.S., McEvoy, J.P., Perkins, D.O., Rothschild, A.J., Sharma, T., Tohen, M.F., Woolson, S., Zipursky, R.B.

“…Few studies have assessed the comparative efficacy and safety of atypical and typical antipsychotic medications in patients within their first episode of…”
Get full text

Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to AIDS by Leserman, Jane, Petitto, John M., Golden, Robert N., Gaynes, Bradley N., Gu, Hongbin, Perkins, Diana O., Silva, Susan G., Folds, James D., Evans, Dwight L.

“…OBJECTIVE: This study examined prospectively the effects of stressful events, depressive symptoms, social support, coping methods, and cortisol levels on…”
Get full text

Factorial structure of the Scale of Prodromal Symptoms by Hawkins, K.A., McGlashan, T.H., Quinlan, D., Miller, T.J., Perkins, D.O., Zipursky, R.B., Addington, J., Woods, S.W.

“…Data from the Scale of Prodromal Symptoms (SOPS) [Early Intervention in Psychotic Disorders, pp. 135–150] on 94 hitherto never-psychotic individuals were…”
Get full text

Penny-wise and pound-foolish: the impact of measurement error on sample size requirements in clinical trials by Perkins, Diana O, Wyatt, Richard Jed, Bartko, John J

“…Background: Clinical research studies must compensate for measurement error by increasing the number of subjects that are studied, thereby increasing the…”
Get full text

The Relationship of Neurocognition and Negative Symptoms to Social and Role Functioning Over Time in Individuals at Clinical High Risk in the First Phase of the North American Prodrome Longitudinal Study by MEYER, Eric C, CARRION, Ricardo E, WOODS, Scott W, HEINSSEN, Robert, SEIDMAN, Larry J, CORNBLATT, Barbara A, ADDINGTON, Jean, CADENHEAD, Kristin S, CANNON, Tyrone D, MCGIASHAN, Thomas H, PERKINS, Diana O, TSUANG, Ming T, WALKER, Elaine F

“…Impaired social, role, and neurocognitive functioning are preillness characteristics of people who later develop psychosis. In people with schizophrenia,…”
Get full text

Characterizing and dating the onset of symptoms in psychotic illness: the Symptom Onset in Schizophrenia (SOS) inventory by Perkins, Diana O., Leserman, Jane, Jarskog, L.Fredrik, Graham, Karen, Kazmer, Janet, Lieberman, Jeffrey A.

“…Prodromal symptoms, including disturbances of perceptions, beliefs, cognition, affect, and behavior, are often the first symptoms of schizophrenia. Little is…”
Get full text

Premorbid social adjustment and association with attenuated psychotic symptoms in clinical high-risk and help-seeking youth by Tarbox-Berry, S I, Perkins, D O, Woods, S W, Addington, J

“…Attenuated positive symptom syndrome (APSS), characterized by 'putatively prodromal' attenuated psychotic-like pathology, indicates increased risk for…”
Get more information

Persistent negative symptoms in youth at clinical high risk for psychosis: A longitudinal study by Devoe, D.J., Lu, L., Cannon, T.D., Cadenhead, K.S., Cornblatt, B.A., McGlashan, T.H., Perkins, D.O., Seidman, L.J., Tsuang, M.T., Woods, S.W., Walker, E.F., Mathalon, D.H., Bearden, C.E., Addington, J.

“…Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area…”
Get full text

Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder by Charney, A W, Ruderfer, D M, Stahl, E A, Moran, J L, Chambert, K, Belliveau, R A, Forty, L, Gordon-Smith, K, Di Florio, A, Lee, P H, Bromet, E J, Buckley, P F, Escamilla, M A, Fanous, A H, Fochtmann, L J, Lehrer, D S, Malaspina, D, Marder, S R, Morley, C P, Nicolini, H, Perkins, D O, Rakofsky, J J, Rapaport, M H, Medeiros, H, Sobell, J L, Green, E K, Backlund, L, Bergen, S E, Juréus, A, Schalling, M, Lichtenstein, P, Roussos, P, Knowles, J A, Jones, I, Jones, L A, Hultman, C M, Perlis, R H, Purcell, S M, McCarroll, S A, Pato, C N, Pato, M T, Craddock, N, Landén, M, Smoller, J W, Sklar, P

“…We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar…”
Get full text