Search Results - "PEREIRA, Manuela M."

Taxonomic distribution, structure/function relationship and metabolic context of the two families of sulfide dehydrogenases: SQR and FCSD by Sousa, Filipe M., Pereira, Juliana G., Marreiros, Bruno C., Pereira, Manuela M.

“…Hydrogen sulfide (H2S) is a versatile molecule with different functions in living organisms: it can work as a metabolite of sulfur and energetic metabolism or…”
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The Ion-Translocating NrfD-Like Subunit of Energy-Transducing Membrane Complexes by Calisto, Filipa, Pereira, Manuela M

“…Several energy-transducing microbial enzymes have their peripheral subunits connected to the membrane through an integral membrane protein, that interacts with…”
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Structural basis for energy transduction by respiratory alternative complex III by Sousa, Joana S., Calisto, Filipa, Langer, Julian D., Mills, Deryck J., Refojo, Patrícia N., Teixeira, Miguel, Kühlbrandt, Werner, Vonck, Janet, Pereira, Manuela M.

“…Electron transfer in respiratory chains generates the electrochemical potential that serves as energy source for the cell. Prokaryotes can use a wide range of…”
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A missing link between complex I and group 4 membrane-bound [NiFe] hydrogenases by Marreiros, Bruno C., Batista, Ana P., Duarte, Afonso M.S., Pereira, Manuela M.

“…Complex I of respiratory chains is an energy transducing enzyme present in most bacteria, mitochondria and chloroplasts. It catalyzes the oxidation of NADH and…”
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Type II NADH:quinone oxidoreductase family: phylogenetic distribution, structural diversity and evolutionary divergences by Marreiros, Bruno C., Sena, Filipa V., Sousa, Filipe M., Batista, Ana P., Pereira, Manuela M.

“…Summary Type II NADH:quinone oxidoreductases (NDH‐2s) are membrane proteins, crucial for the catabolic metabolism, because they contribute to the maintenance…”
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Type‐II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction by Sena, Filipa V., Batista, Ana P., Catarino, Teresa, Brito, José A., Archer, Margarida, Viertler, Martin, Madl, Tobias, Cabrita, Eurico J., Pereira, Manuela M.

“…Summary A prerequisite for any rational drug design strategy is understanding the mode of protein–ligand interaction. This motivated us to explore…”
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The Alternative complex III: Properties and possible mechanisms for electron transfer and energy conservation by Refojo, Patrícia N., Teixeira, Miguel, Pereira, Manuela M.

“…Alternative complexes III (ACIII) are recently identified membrane-bound enzymes that replace functionally the cytochrome bc1/b6f complexes. In general, ACIII…”
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Catalytic Activity and Proton Translocation of Reconstituted Respiratory Complex I Monitored by Surface-Enhanced Infrared Absorption Spectroscopy by Gutiérrez-Sanz, Oscar, Forbrig, Enrico, Batista, Ana P, Pereira, Manuela M, Salewski, Johannes, Mroginski, Maria A, Götz, Robert, De Lacey, Antonio L, Kozuch, Jacek, Zebger, Ingo

“…Respiratory complex I (CpI) is a key player in the way organisms obtain energy, being an energy transducer, which couples nicotinamide adenine dinucleotide…”
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A bioinformatics classifier and database for heme-copper oxygen reductases by Sousa, Filipa L, Alves, Renato J, Pereira-Leal, José B, Teixeira, Miguel, Pereira, Manuela M

“…Heme-copper oxygen reductases (HCOs) are the last enzymatic complexes of most aerobic respiratory chains, reducing dioxygen to water and translocating up to…”
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In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal Activity in Leishmania infantum by Stevanović, Strahinja, Perdih, Andrej, Senćanski, Milan, Glišić, Sanja, Duarte, Margarida, Tomás, Ana M, Sena, Filipa V, Sousa, Filipe M, Pereira, Manuela M, Solmajer, Tom

“…There is an urgent need for the discovery of new antileishmanial drugs with a new mechanism of action. Type 2 NADH dehydrogenase from ( NDH2) is an enzyme of…”
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The two alternative NADH:quinone oxidoreductases from Staphylococcus aureus : two players with different molecular and cellular roles by Sena, Filipa V, Sousa, Filipe M, Pereira, Ana R, Catarino, Teresa, Cabrita, Eurico J, Pinho, Mariana G, Pinto, Francisco R, Pereira, Manuela M

“…is an opportunistic pathogen that has emerged as a major public health threat due to the increased incidence of its drug resistance. presents a remarkable…”
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The alternative complex III: A different architecture using known building modules by Refojo, Patrícia N., Sousa, Filipa L., Teixeira, Miguel, Pereira, Manuela M.

“…Until recently cytochrome bc 1 complexes were the only enzymes known to be able to transfer electrons from reduced quinones to cytochrome c. However, a complex…”
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Regulation of the mechanism of Type-II NADH: Quinone oxidoreductase from S. aureus by Sena, Filipa V., Sousa, Filipe M., Oliveira, A. Sofia F., Soares, Cláudio M., Catarino, Teresa, Pereira, Manuela M.

“…Type-II NADH:quinone oxidoreductases (NDH-2s) are membrane proteins involved in respiratory chains and the only enzymes with NADH:quinone oxidoreductase…”
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Looking for the minimum common denominator in haem–copper oxygen reductases: Towards a unified catalytic mechanism by Pereira, Manuela M., Sousa, Filipa L., Veríssimo, Andreia F., Teixeira, Miguel

“…Haem–copper oxygen reductases are transmembrane protein complexes that reduce dioxygen to water and pump protons across the mitochondrial or periplasmatic…”
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Proximal mutations at the type 1 copper site of CotA laccase: spectroscopic, redox, kinetic and structural characterization of I494A and L386A mutants by Durão, Paulo, Chen, Zhenjia, Silva, Catarina S, Soares, Cláudio M, Pereira, Manuela M, Todorovic, Smilja, Hildebrandt, Peter, Bento, Isabel, Lindley, Peter F, Martins, Lígia O

“…In the present study the CotA laccase from Bacillus subtilis has been mutated at two hydrophobic residues in the vicinity of the type 1 copper site. The…”
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Modularity of membrane-bound charge-translocating protein complexes by Calisto, Filipa, Pereira, Manuela M

“…Energy transduction is the conversion of one form of energy into another; this makes life possible as we know it. Organisms have developed different systems…”
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Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway by TAN, Chalet, DE NORONHA, Rita G, WEI ZHOU, OLSON, Jeffrey J, PEREIRA, M. Manuela, NICOLAOU, K. C, VAN MEIR, Erwin G, ROECKER, Anthony J, PYRZYNSKA, Beata, KHWAJA, Fatima, ZHAOBIN ZHANG, HUANCHUN ZHANG, QUINCY TENG, NICHOLSON, Ainsley C, GIANNAKAKOU, Paraskevi

“…Hypoxia-inducible factor 1 (HIF-1) is the central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for…”
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The role of proton and sodium ions in energy transduction by respiratory complex I by Batista, Ana P., Marreiros, Bruno C., Pereira, Manuela M.

“…Respiratory complex I plays a central role in energy transduction. It catalyzes the oxidation of NADH and the reduction of quinone, coupled to cation…”
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Decoupling of the Catalytic and Transport Activities of Complex I from Rhodothermus marinus by Sodium/Proton Antiporter Inhibitor by Batista, Ana P, Marreiros, Bruno C, Pereira, Manuela M

“…The energy transduction by complex I from Rhodothermus marinus was addressed by studying the influence of 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on the…”
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The alternative complex III from Rhodothermus marinus – A prototype of a new family of quinol:electron acceptor oxidoreductases by Pereira, Manuela M., Refojo, Patricia N., Hreggvidsson, Gudmundur O., Hjorleifsdottir, Sigridur, Teixeira, Miguel

“…The biochemical and genetic search for a bc 1 complex in Rhodothermus marinus was always fruitless; however, a functional equivalent, i.e. having…”
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