Search Results - "PEPPERKOK, R"

The potential of high‐content high‐throughput microscopy in drug discovery by Starkuviene, V, Pepperkok, R

“…Fluorescence microscopy is a powerful method to study protein function in its natural habitat, the living cell. With the availability of the green fluorescent…”
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Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1 by Moudry, P, Lukas, C, Macurek, L, Neumann, B, Heriche, J-K, Pepperkok, R, Ellenberg, J, Hodny, Z, Lukas, J, Bartek, J

“…53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling…”
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Membrane dynamics in the early secretory pathway [Erratum: 2007, v. 26, issue 5-6, p. 285.] by Robinson, D.G, Herranz, M.C, Bubeck, J, Pepperkok, R, Ritzenthaler, C

“…All eukaryotes possess a secretory pathway, and the major molecular players involved in secretion are well conserved. However, the morphological manifestation…”
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S274: A NOVEL SUBTYPE OF ANEMIA CAUSED BY MUTATIONS IN TFRC GENE by Colucci, S., Venturi, V., Nicole, F., Jové Solavera, D., Zimon, M., Richter‐Pechanska, P., Hernandez, G., Unal, S., Gumruk, F., Diaz‐Conradi, A., Romero‐Cortadellas, L., Ferrer‐Cortès, X., Olivella, M., Erlacher, M., Niemeyer, C., Wiesel, T., Pepperkok, R., Fleming, M. D., Kulozik, A. E., Sanchez, M., Muckenthaler, M. U.

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Cyclin A is required at two points in the human cell cycle by Pagano, M., Pepperkok, R., Verde, F., Ansorge, W., Draetta, G.

“…Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of…”
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Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway by VERISSIMO, F, SILVA, E, MORRIS, J. D, PEPPERKOK, R, JORDAN, P

“…The subfamily of WNK (with no K= lysine) protein kinases has four human members and germline mutations in the WNK1 and WNK4 genes were recently found to cause…”
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The Many Ways to Cross the Plasma Membrane by Stephens, David J., Pepperkok, Rainer

“…The temporal and spatial regulation of protein systems that underlie basic cellular functions is examined, focusing on current methodologies for the…”
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WS20.6 High throughput screening as a source for novel cystic fibrosis therapeutic targets by Botelho, H.M, Dahimène, S, Uliyakina, I, Neumann, B, Tischer, C, Pepperkok, R, Amaral, M.D

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The p24 family member p23 is required for early embryonic development by Denzel, A., Otto, F., Girod, A., Pepperkok, R., Watson, R., Rosewell, I., Bergeron, J.J.M., Solarie, R.C.E., Owen, M.J.

“…The p24 family of type I integral-membrane proteins, which are localised in the endoplasmic reticulum (ER) [1–3], the intermediate compartment and the Golgi…”
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Regulation of G1 progression by E2A and Id helix‐loop‐helix proteins by Peverali, F.A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M.V., Philipson, L.

“…In NIH3T3 fibroblasts, the ubiquitous helix‐loop‐helix (HLH) protein E2A (E12/E47) and the myogenic HLH proteins MyoD, MRF4 and myogenin are growth‐inhibitory,…”
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Casein kinase II is required for transition of G0/G1, early G1, and G1/S phases of the cell cycle by PEPPERKOK, R, LORENZ, P, ANSORGE, W, PYERIN, W

“…Casein kinase II (CKII) is a ubiquitous serine/threonine protein kinase with many cellular functions, including participation in mitogenic signaling by…”
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The Src Family Tyrosine Kinases are Required for Platelet-Derived Growth Factor-Mediated Signal Transduction in NIH 3T3 Cells by Twamley-Stein, Geraldine M., Pepperkok, Rainer, Ansorge, Wilhelm, Courtneidge, Sara A.

“…Three members of the Src family of protein tyrosine kinases Src, Fyn, and Yes associate with the activated platelet-derived growth factor (PDGF) receptor in…”
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Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo by Pepperkok, R, Scheel, J, Horstmann, H, Hauri, H P, Griffiths, G, Kreis, T E

“…Microinjection of antibodies against a synthetic peptide of a non-clathrin-coated vesicle-associated coat protein, beta-COP, blocks transport of a…”
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Transcription-Dependent Colocalization of the U1, U2, U4/U6, and U5 snRNPs in Coiled Bodies by Carmo-Fonseca, Maria, Pepperkok, Rainer, Carvalho, Maria Teresa, Lamond, Angus I.

“…We have recently shown that discrete foci are present in the nuclei of mammalian cells in which each of the U1, U2, U4/U6, and U5 snRNPs involved in pre-mRNA…”
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Id Proteins Control Growth Induction in Mammalian Cells by Barone, M. Vittoria, Pepperkok, Rainer, Peverali, Fiorenzo A., Philipson, Lennart

“…Id1, Id2, and Id3 (HLH462) dimerize with members of the basic helix-loop-helix protein family, but due to the absence of the basic region, the resulting…”
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The Golgi complex serves as a platform for the DNA damage response pathways by Kuodyte, K., Galea, G., Käller Lundberg, Emma, Pepperkok, R.

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The Golgi complex serves as a platform for the DNA damage response pathways by Kuodyte, K., Galea, G., Käller Lundberg, Emma, Pepperkok, R.

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Cell biological studies with monoclonal and polyclonal antibodies against human casein kinase II subunit beta demonstrate participation of the kinase in mitogenic signaling by Lorenz, P, Pepperkok, R, Ansorge, W, Pyerin, W

“…Casein kinase II (CKII) is a highly conserved ubiquitous serine/threonine kinase composed of two catalytically active (alpha and/or alpha') and two regulatory…”
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Dyskerin Localizes to the Nucleolus and Its Mislocalization Is Unlikely to Play a Role in the Pathogenesis of Dyskeratosis Congenita by Heiss, Nina S., Girod, Andreas, Salowsky, Rudiger, Wiemann, Stefan, Pepperkok, Rainer, Poustka, Annemarie

“…Mutations in the DKC1 gene are responsible for causing the bone marrow failure syndrome, dyskeratosis congenita (DKC; OMIM 305000). The majority of mutations…”
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High-throughput microscopy profiling of LDLR variants by Graça, R., Zimon, M., Alves, A.C., Pepperkok, R., Bourbon, M.

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