Search Results - "PEPPER, Michael S"

The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review by Atashi, Fatemeh, Modarressi, Ali, Pepper, Michael S

“…Mesenchymal stromal cells (MSCs) are promising candidates for tissue engineering and regenerative medicine. The multipotent stem cell component of MSC isolates…”
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Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways by Ambele, Melvin A, Dhanraj, Priyanka, Giles, Rachel, Pepper, Michael S

“…The formation of adipocytes during embryogenesis has been largely understudied. However, preadipocytes appear to originate from multipotent mesenchymal…”
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SARS-CoV-2 Variants, Vaccines, and Host Immunity by Mistry, Priyal, Barmania, Fatima, Mellet, Juanita, Peta, Kimberly, Strydom, Adéle, Viljoen, Ignatius M, James, William, Gordon, Siamon, Pepper, Michael S

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus that emerged at the end of 2019 in the Hubei province of China…”
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A COVID-19 Vaccine: Big Strides Come with Big Challenges by Mellet, Juanita, Pepper, Michael S

“…As of 8 January 2021, there were 86,749,940 confirmed coronavirus disease 2019 (COVID-19) cases and 1,890,342 COVID-19-related deaths worldwide, as reported by…”
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Lessons Learned from Somatic Cell Nuclear Transfer by Gouveia, Chantel, Huyser, Carin, Egli, Dieter, Pepper, Michael S

“…Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell research and regenerative medicine for the past 20 years. The main…”
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The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer by Senthebane, Dimakatso Alice, Rowe, Arielle, Thomford, Nicholas Ekow, Shipanga, Hendrina, Munro, Daniella, Mazeedi, Mohammad A M Al, Almazyadi, Hashim A M, Kallmeyer, Karlien, Dandara, Collet, Pepper, Michael S, Parker, M Iqbal, Dzobo, Kevin

“…Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced…”
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Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair by André-Lévigne, Dominik, Modarressi, Ali, Pepper, Michael S, Pittet-Cuénod, Brigitte

“…Our understanding of the role of oxygen in cell physiology has evolved from its long-recognized importance as an essential factor in oxidative metabolism to…”
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Molecular mechanisms underpinning sarcomas and implications for current and future therapy by Damerell, Victoria, Pepper, Michael S., Prince, Sharon

“…Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical management is highly challenging due to their heterogeneity and insensitivity…”
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Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation by Potgieter, Marnie, Pretorius, Etheresia, Pepper, Michael S

“…Coenzyme Q10 (CoQ10) is the only lipid‐soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known…”
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An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells by Mollentze, Jamie, Durandt, Chrisna, Pepper, Michael S.

“…The use of stem cells in regenerative medicine, including tissue engineering and transplantation, has generated a great deal of enthusiasm. Mesenchymal…”
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The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms by da Silva, Carina, Durandt, Chrisna, Kallmeyer, Karlien, Ambele, Melvin A, Pepper, Michael S

“…Obesity contributes significantly to the global health burden. A better understanding of adipogenesis, the process of fat formation, may lead to the discovery…”
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Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans by Choudhury, Ananyo, Ramsay, Michèle, Hazelhurst, Scott, Aron, Shaun, Bardien, Soraya, Botha, Gerrit, Chimusa, Emile R., Christoffels, Alan, Gamieldien, Junaid, Sefid-Dashti, Mahjoubeh J., Joubert, Fourie, Meintjes, Ayton, Mulder, Nicola, Ramesar, Raj, Rees, Jasper, Scholtz, Kathrine, Sengupta, Dhriti, Soodyall, Himla, Venter, Philip, Warnich, Louise, Pepper, Michael S.

“…The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a…”
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Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion by Dessels, Carla, Durandt, Chrisna, Pepper, Michael S

“…Pooled human platelet lysate (pHPL) has been used to expand adipose-derived stromal cells (ASCs) and can be formulated using fresh or expired buffy coats (BCs)…”
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Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review by Tata, Emiliene B, Ambele, Melvin A, Pepper, Michael S

“…Clinical research in high-income countries is increasingly demonstrating the cost- effectiveness of clinical pharmacogenetic (PGx) testing in reducing the…”
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A data management plan for the NESHIE observational study by Strydom, Adéle, Van Rensburg, Jeanne, Pepper, Michael S

“…With regard to the use and transfer of research participants' personal information, samples and other data nationally and internationally, it is necessary to…”
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Extensive immunophenotypic sub-population analysis of StemRegenin1 expanded haematopoietic stem/progenitor cells by Mellet, Juanita, Hendricks, Candice L, Stivaktas, Voula, Durandt, Chrisna, Ambele, Melvin A, Pepper, Michael S

“…Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an important area of research, and has the potential to improve access to umbilical…”
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Fate of systemically and locally administered adipose‐derived mesenchymal stromal cells and their effect on wound healing by Kallmeyer, Karlien, André‐Lévigne, Dominik, Baquié, Mathurin, Krause, Karl‐Heinz, Pepper, Michael S., Pittet‐Cuénod, Brigitte, Modarressi, Ali

“…There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly…”
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Human cloning as reproductive means in future: a qualitative thematic study of underpinning values by Castelyn, Camille, Van Staden, Werdie, Pepper, Michael S

“…The possibility of using human cloning to reproduce has been met with unease, shock, and prohibition in many countries, as well as the International Committee…”
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Considerations for enhanced mesenchymal stromal/stem cell myogenic commitment in vitro by Grobbelaar, Simone, Mercier, Anne E., Bout, Iman, Durandt, Chrisna, Pepper, Michael S.

“…The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative…”
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Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules by Mercier, Anne E, Prudent, Renaud, Pepper, Michael S, De Koning, Leanne, Nolte, Elsie, Peronne, Lauralie, Nel, Marcel, Lafanechère, Laurence, Joubert, Anna M

“…The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-…”
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