Search Results - "PENNATI, M"

Targeting survivin in cancer therapy: fulfilled promises and open questions by Pennati, Marzia, Folini, Marco, Zaffaroni, Nadia

“…Survivin is a bifunctional protein that acts as a suppressor of apoptosis and plays a central role in cell division. The protein is strongly expressed in the…”
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Comparative diagnostic performance of rapid antigen detection tests for COVID-19 in a hospital setting by Bruzzone, Bianca, De Pace, Vanessa, Caligiuri, Patrizia, Ricucci, Valentina, Guarona, Giulia, Pennati, Beatrice M., Boccotti, Simona, Orsi, Andrea, Domnich, Alexander, Da Rin, Giorgio, Icardi, Giancarlo

“…•Not all available rapid SARS-CoV-2 antigen tests have a sensitivity of ≥80/90%.•Sensitivity of rapid SARS-CoV-2 antigen tests is primarily driven by viral…”
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Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)- 1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsentin analogues by Carbone, A, Pennati, M, Barraja, P, Montalbano, A, Parrino, B, Spanò, V, Lopergolo, A, Sbarra, S, Doldi, V, Zaffaroni, N, Cirrincione, G, Diana, P

“…A large number of indolyl-4-azaindolyl thiazoles, nortopsentin analogues, were conveniently synthesized. The antiproliferative activity of the new derivatives…”
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Pazopanib in advanced germ cell tumors after chemotherapy failure: results of the open-label, single-arm, phase 2 Pazotest trial by Necchi, A., Lo Vullo, S., Giannatempo, P., Raggi, D., Calareso, G., Togliardi, E., Crippa, F., Pennati, M., Zaffaroni, N., Perrone, F., Busico, A., Colecchia, M., Nicolai, N., Mariani, L., Salvioni, R.

“…Therapeutic options for patients with chemoresistant germ cell tumors (GCTs) are limited. Pazopanib is a selective tyrosine kinase inhibitor with distinct…”
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PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1, in pre-treated patients with urothelial cancer: an open label, single-group, phase 2 trial by Necchi, A., Giannatempo, P., Mariani, L., Farè, E., Raggi, D., Pennati, M., Zaffaroni, N., Crippa, F., Marchianò, A., Nicolai, N., Maffezzini, M., Togliardi, E., Daidone, M. G., Gianni, A. M., Salvioni, R., De Braud, F.

“…Summary Despite a compelling preclinical rationale for the use of anti-angiogenic drugs in urothelial cancer (UC), short-living responses have been observed in…”
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Circulating angiogenesis-related markers as predictors of benefit from regorafenib in metastatic colorectal cancer (mCRC) patients (pts) by Antoniotti, C., Marmorino, F., Pennati, M., Zaffaroni, N., Rossini, D., Borelli, B., Zucchelli, G., Moretto, R., Pietrantonio, F., Masi, G., Vannini, F., Colombo, C., Saettini, A., Gini, S., Delliponti, L., Pfanner, E., Brunetti, I., Falcone, A., Cremolini, C.

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Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer by Zaffaroni, N, Pennati, M, Colella, G, Perego, P, Supino, R, Gatti, L, Pilotti, S, Zunino, F, Daidone, M G

“…Stable transfection of human ovarian carcinoma cells with survivin cDNA caused a four- to sixfold increase in cell resistance to taxotere and taxol (two-sided…”
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Parameter Sensitivity Analysis of a Passenger/Seat Model for Ride Comfort Assessment by Brogioli, M., Gobbi, M., Mastinu, G., Pennati, M.

“…The paper deals with the parameter sensitivity analysis of a passenger/seat model that can be used for ride comfort assessments. The final aim is to produce a…”
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Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation by Lopergolo, A, Pennati, M, Gandellini, P, Orlotti, N I, Poma, P, Daidone, M G, Folini, M, Zaffaroni, N

“…We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the…”
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Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy by Necchi, A, Pennati, M, Zaffaroni, N, Landoni, E, Giannatempo, P, Raggi, D, Schwartz, L H, Morosi, C, Crippa, F, Farè, E, Nicolai, N, Lanocita, R, Sava, T, Sacco, C, Messina, C, Ortega, C, De Braud, F G, Salvioni, R, Daidone, M G, Gianni, A M, Mariani, L

“…Background: Pazopanib achieved the end point of clinical activity in pretreated patients with urothelial cancer in a single-group, phase 2 trial. The objective…”
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A dummy for the objective ride comfort evaluation of ground vehicles by Pennati, M., Gobbi, M., Mastinu, G.

“…A new device for an objective evaluation of ground vehicle ride comfort is presented. In this study, the ride comfort (frequency range 0-30 Hz) has been…”
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75 YM155-mediated Inhibition of Survivin Expression Enhances TRAIL-induced Apoptosis in Human Triple-negative Breast Cancer Cells by Pennati, M, Sbarra, S, De Cesare, M, Locatelli, S.L, Carlo-Stella, C, Zaffaroni, N

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Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment by Gatti, L, Cossa, G, Tinelli, S, Carenini, N, Arrighetti, N, Pennati, M, Cominetti, D, De Cesare, M, Zunino, F, Zaffaroni, N, Perego, P

“…Since response to platinum-based therapy in non-small-cell lung cancer (NSCLC) is poor, the present study was designed to rationally identify novel drug…”
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Ribozyme-mediated down-regulation of survivin expression sensitizes human melanoma cells to topotecan in vitro and in vivo by Pennati, Marzia, Binda, Mara, De Cesare, Michelandrea, Pratesi, Graziella, Folini, Marco, Citti, Lorenzo, Daidone, Maria Grazia, Zunino, Franco, Zaffaroni, Nadia

“…The ability of melanoma cells to evade engagement of apoptosis plays a significant role in their resistance to chemotherapy. In an attempt to lower the…”
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436 Interleukin-8 (IL8) and Transforming Growth-Factor Beta (TGF-β) as Drugable Biomarkers of Response, Progression-free (PFS) and Overall Survival (OS) with Pazopanib (PZP): a Phase II Study in Relapsed Urothelial Cancer (UC) by Necchi, A, Zaffaroni, N, Mariani, L, Giannatempo, P, Nicolai, N, Pennati, M, Daidone, M.G, Gianni, A.M, De Braud, F.G, Salvioni, R

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Evaluation of extraction-free RT-qPCR methods for SARS-CoV-2 diagnostics by Domnich, Alexander, De Pace, Vanessa, Pennati, Beatrice M., Caligiuri, Patrizia, Varesano, Serena, Bruzzone, Bianca, Orsi, Andrea

“…Extraction-based real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) is currently the “gold standard” in SARS-CoV-2 diagnostics…”
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Indoor testing of road vehicle suspensions by Gobbi, M., Mastinu, G., Pennati, M.

“…The paper presents a method for the indoor testing of road vehicle suspension systems. A car suspension is positioned on a rotating drum located in the…”
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Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions by COLELLA, G, PENNATI, M, BEARZATTO, A, LEONE, R, COLANGELO, D, MANZOTTI, C, DAIDONE, M. G, ZAFFARONI, N

“…A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to…”
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Approaches for the inhibition of human telomerase based on the use of peptide nucleic acids and hammerhead ribozymes by Zaffaroni, N, Villa, R, Pennati, M, Folini, M

“…The ability of peptide nucleic acids and hammerhead ribozymes, which target different subunits of human telomerase, to efficiently inhibit the enzyme's…”
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535 miR-205-mediated reversal of epithelial–mesenchymal transition modifies the drug sensitivity profile of prostate cancer cells by Pennati, M, Gandellini, P, Profumo, V, Orlotti, N.I, Daidone, M.G, Folini, M, Zaffaroni, N

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