Influence of antimicrobial chemotherapy and smoking status on the plasma concentrations of vitamin C, vitamin E, β-carotene, acute phase reactants, iron and lipid peroxides in patients with pulmonary tuberculosis

SETTING: Inflammation-related oxidative stress has been implicated in the pathogenesis of lung fibrosis and dysfunction in patients with pulmonary tuberculosis.OBJECTIVE: To investigate the effects of antimicrobial chemotherapy and smoking status on the plasma concentrations of the anti-oxidative nu...

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Published in:	The international journal of tuberculosis and lung disease Vol. 2; no. 7; pp. 590 - 596
Main Authors:	PLIT, M. L, THERON, A. J, FICKL, H, VAN RENSBURG, C. E. J, PENDEL, S, ANDERSON, R
Format:	Journal Article
Language:	English
Published:	Paris, France IUATLD 01-07-1998 Union internationale contre la tuberculose et les maladies respiratoires
Subjects:	Acute-Phase Proteins - analysis Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antioxidants - metabolism Antitubercular Agents - therapeutic use Ascorbic Acid - blood beta Carotene - blood Biological and medical sciences Female Humans Iron - blood Lipid Peroxides Lipid Peroxides - blood Male Medical sciences Middle Aged Oxidative Stress Pharmacology. Drug treatments Pulmonary Tuberculosis Respiratory Function Tests Smoking - blood Smoking - physiopathology Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - physiopathology Vitamin C Vitamin E Vitamin E - blood Β-Carotene Human Lung disease Ascorbic acid Respiratory disease Lung Tobacco smoking Exploration Lipids α-Tocopherol Iron Mycobacterial infection Antioxidant Blood plasma Infection Chemotherapy Acute phase protein Tuberculosis Bacteriosis Antituberculous agent Peroxides Betacarotene Trace element (nutrient)
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Summary:	SETTING: Inflammation-related oxidative stress has been implicated in the pathogenesis of lung fibrosis and dysfunction in patients with pulmonary tuberculosis.OBJECTIVE: To investigate the effects of antimicrobial chemotherapy and smoking status on the plasma concentrations of the anti-oxidative nutrients vitamin C, vitamin E and β-carotene, as well as those of iron, lipid peroxides and the acute phase reactants C-reactive protein (CRP) and ferritin.DESIGN: A total of 41 patients with active pulmonary tuberculosis were studied at the outset and after 6 months of antimicrobial chemotherapy.RESULTS: Initial plasma concentrations of vitamin C and β-carotene were low, returning to normal values after chemotherapy in the non-smokers, but not in the smokers, while those of vitamin E remained low throughout in both groups. Ferritin and CRP concentrations decreased significantly following chemotherapy, with the former higher in smokers than in non-smokers. Serum lipid peroxides were elevated in patients with pulmonary tuberculosis and were unaffected by chemotherapy or smoking habits, while iron levels were not significantly affected by chemotherapy. Although residual dysfunction and infiltration were evident, pulmonary function (FEV1) and radiographic score improved equally in both smokers and non-smokers following antimicrobial chemotherapy.CONCLUSIONS: Even after 6 months of apparently successful antimicrobial chemotherapy, pulmonary tuberculosis is associated with increased oxidative stress, which is unrelated to cigarette smoking and characterized by increased levels of circulating lipid peroxides and low concentrations of plasma vitamin E.
Bibliography:	(R) Medicine - General 1027-3719(19980701)2:7L.590;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1027-3719 1815-7920