Search Results - "PELZER, Theo"

Development and validation of a sensitive liquid chromatography tandem mass spectrometry assay for the simultaneous determination of ten kinase inhibitors in human serum and plasma by Aghai, Fatemeh, Zimmermann, Sebastian, Kurlbaum, Max, Jung, Pius, Pelzer, Theo, Klinker, Hartwig, Isberner, Nora, Scherf-Clavel, Oliver

“…A liquid chromatography tandem mass spectrometry method for the analysis of ten kinase inhibitors (afatinib, axitinib, bosutinib, cabozantinib, dabrafenib,…”
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Whitening and Impaired Glucose Utilization of Brown Adipose Tissue in a Rat Model of Type 2 Diabetes Mellitus by Lapa, Constantin, Arias-Loza, Paula, Hayakawa, Nobuyuki, Wakabayashi, Hiroshi, Werner, Rudolf A., Chen, Xinyu, Shinaji, Tetsuya, Herrmann, Ken, Pelzer, Theo, Higuchi, Takahiro

“…Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic…”
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[68Ga]Pentixafor-PET/CT for imaging of chemokine receptor 4 expression in small cell lung cancer--initial experience by Lapa, Constantin, Lückerath, Katharina, Rudelius, Martina, Schmid, Jan-Stefan, Schoene, Alexander, Schirbel, Andreas, Samnick, Samuel, Pelzer, Theo, Buck, Andreas K, Kropf, Saskia, Wester, Hans-Jürgen, Herrmann, Ken

“…Chemokine receptor CXCR4 is a key factor for tumor growth and metastasis in several types of human cancer. This study investigated the feasibility of…”
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Somatostatin receptor expression in small cell lung cancer as a prognostic marker and a target for peptide receptor radionuclide therapy by Lapa, Constantin, Hänscheid, Heribert, Wild, Vanessa, Pelzer, Theo, Schirbel, Andreas, Werner, Rudolf A, Droll, Sabine, Herrmann, Ken, Buck, Andreas K, Lückerath, Katharina

“…Despite initial responsiveness to both chemotherapy and radiotherapy, small cell lung cancer (SCLC) commonly relapses within months. Although neuroendocrine…”
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Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated 18F-FDG PET by Werner, Rudolf A., Eissler, Christoph, Hayakawa, Nobuyuki, Arias-Loza, Paula, Wakabayashi, Hiroshi, Javadi, Mehrbod S., Chen, Xinyu, Shinaji, Tetsuya, Lapa, Constantin, Pelzer, Theo, Higuchi, Takahiro

“…In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development…”
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Impact of tissue photon attenuation in small animal cardiac PET imaging by Hayakawa, Nobuyuki, Yamane, Tomohiko, Arias-Loza, Anahi Paula, Shinaji, Tetsuya, Wakabayashi, Hiroshi, Lapa, Constantin, Werner, Rudolf, Javadi, Mehrbod S, Pelzer, Theo, Higuchi, Takahiro

“…A bstract Objectives Tissue photon attenuation is one of the essential artifacts requiring correction in clinical cardiac positron emission tomography (PET)…”
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Impact of thoracic surgery on cardiac morphology and function in small animal models of heart disease: a cardiac MRI study in rats by Nordbeck, Peter, Bönhof, Leoni, Hiller, Karl-Heinz, Voll, Sabine, Arias-Loza, Paula, Seidlmayer, Lea, Williams, Tatjana, Ye, Yu-Xiang, Gensler, Daniel, Pelzer, Theo, Ertl, Georg, Jakob, Peter M, Bauer, Wolfgang R, Ritter, Oliver

“…Surgical procedures in small animal models of heart disease might evoke alterations in cardiac morphology and function. The aim of this study was to reveal and…”
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Genetic and pharmacologic strategies to determine the function of estrogen receptor α and estrogen receptor β in cardiovascular system by Arias-Loza, Paula Anahi, MSc, Jazbutyte, Virginija, PhD, Pelzer, Theo, MD

“…Abstract Background: The biological functions of estrogens extend beyond the female and male reproductive tract, affecting the cardiovascular and renal…”
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Efficacy of the irreversible ErbB family blocker afatinib in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-pretreated non-small-cell lung cancer patients with brain metastases or leptomeningeal disease by Hoffknecht, Petra, Tufman, Amanda, Wehler, Thomas, Pelzer, Theo, Wiewrodt, Rainer, Schütz, Martin, Serke, Monika, Stöhlmacher-Williams, Jan, Märten, Angela, Maria Huber, Rudolf, Dickgreber, Nicolas J

“…Afatinib is an effective first-line treatment in patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) and has shown…”
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Journey of a patient with chronic thromboembolic pulmonary hypertension by Liu, Dan, Hu, Kai, Pelzer, Heinz-Theo, Störk, Stefan, Weidemann, Frank

“…Right ventricle (RV) dysfunction is a key outcome determinant and a leading cause of death for patients with chronic thromboembolic pulmonary hypertension…”
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Volumetric absorptive microsampling (VAMS) for the quantification of ten kinase inhibitors and determination of their in vitro VAMS-to-plasma ratio by Zimmermann, Sebastian, Aghai, Fatemeh, Schilling, Bastian, Kraus, Sabrina, Grigoleit, Götz Ulrich, Kalogirou, Charis, Goebeler, Maria-Elisabeth, Jung, Pius, Pelzer, Theo, Klinker, Hartwig, Isberner, Nora, Scherf-Clavel, Oliver

“…•The VAMS method is capable for quantification of ten kinase inhibitors.•A compound specific VAMS-to-plasma conversion factor was established.•Clinical…”
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Comparison of a newly developed high performance liquid chromatography method with diode array detection to a liquid chromatography tandem mass spectrometry method for the quantification of cabozantinib, dabrafenib, nilotinib and osimertinib in human serum – Application to therapeutic drug monitoring by Aghai-Trommeschlaeger, Fatemeh, Zimmermann, Sebastian, Gesierich, Anja, Kalogirou, Charis, Goebeler, Maria-Elisabeth, Jung, Pius, Pelzer, Theo, Kurlbaum, Max, Klinker, Hartwig, Isberner, Nora, Scherf-Clavel, Oliver

“…Liquid chromatography tandem mass spectrometry (LC-MS/MS) is a highly selective and sensitive method for the quantification of kinase inhibitors, yet not…”
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Estrogen and estrogen receptors in cardiovascular oxidative stress by Arias-Loza, Paula-Anahi, Muehlfelder, Melanie, Pelzer, Theo

“…The cardiovascular system of a premenopausal woman is prepared to adapt to the challenges of increased cardiac output and work load that accompany pregnancy…”
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Somatostatin receptor based PET/CT in patients with the suspicion of cardiac sarcoidosis: an initial comparison to cardiac MRI by Lapa, Constantin, Reiter, Theresa, Kircher, Malte, Schirbel, Andreas, Werner, Rudolf A, Pelzer, Theo, Pizarro, Carmen, Skowasch, Dirk, Thomas, Lena, Schlesinger-Irsch, Ulrike, Thomas, Daniel, Bundschuh, Ralph A, Bauer, Wolfgang R, Gärtner, Florian C

“…Diagnosis of cardiac sarcoidosis is often challenging. Whereas cardiac magnetic resonance imaging (CMR) and positron emission tomography/computed tomography…”
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Mechanisms of Estrogen Receptor Action in the Myocardium by de Jager, Tertia, Pelzer, Theo, Müller-Botz, Stephan, Imam, Asiya, Muck, Jenny, Neyses, Ludwig

“…We have previously shown that the myocardium is a target tissue for estrogen. Here, we have identified rapid non-nuclear estrogen effects on the expression of…”
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Development and Characterization of an Inducible Rat Model of Chronic Thromboembolic Pulmonary Hypertension by Arias-Loza, Paula-Anahi, Jung, Pius, Abeer, Marco, Umbenhauer, Sandra, Williams, Tatjana, Frantz, Stefan, Schuh, Kai, Pelzer, Theo

“…Chronic thromboembolic pulmonary hypertension (CTEPH) is an entity of PH that not only limits patients quality of life but also causes significant morbidity…”
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In-Vivo Somatostatin-Receptor Expression in Small Cell Lung Cancer as a Prognostic Image Biomarker and Therapeutic Target by Şen, Feyza, Sheikh, Gabriel T, von Hinten, Johannes, Schindele, Andreas, Kircher, Malte, Dierks, Alexander, Pfob, Christian H, Serfling, Sebastian E, Buck, Andreas K, Pelzer, Theo, Higuchi, Takahiro, Weich, Alexander, Bundschuh, Ralph A, Werner, Rudolf A, Lapa, Constantin

“…Given the dismal prognosis of small cell lung cancer (SCLC), novel therapeutic targets are urgently needed. We aimed to evaluate whether SSTR expression, as…”
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Expression of the Plasma Membrane Ca2+-ATPase in Myogenic Cells by Hammes, Annette, Oberdorf-Maass, Silke, Jenatschke, Susanne, Pelzer, Theo, Maass, Alexander, Gollnick, Frank, Meyer, Rainer, Afflerbach, Jörn, Neyses, Ludwig

“…To study the physiological function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in intact cells, L6 myogenic cell lines stably…”
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Targeting CXCR4 with [ 68 Ga]Pentixafor: a suitable theranostic approach in pleural mesothelioma? by Lapa, Constantin, Kircher, Stefan, Schirbel, Andreas, Rosenwald, Andreas, Kropf, Saskia, Pelzer, Theo, Walles, Thorsten, Buck, Andreas K, Weber, Wolfgang A, Wester, Hans-Juergen, Herrmann, Ken, Lückerath, Katharina

“…C-X-C motif chemokine receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several types of human cancer. This study investigated the…”
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Both estrogen receptor subtypes, ERα and ERβ, prevent aldosterone-induced oxidative stress in VSMC via increased NADPH bioavailability by Muehlfelder, Melanie, Arias-Loza, Paula-Anahi, Fritzemeier, Karl Heinrich, Pelzer, Theo

“…► Estrogens attenuate ALDO-induced oxidative stress in VSMC via increased NADPH generation. ► Estrogens do not block aldosterone-induced increase in NADPH…”
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