Search Results - "PELTON, Stephen I"

The Global Evolution of Meningococcal Epidemiology Following the Introduction of Meningococcal Vaccines by Pelton, Stephen I., M.D

“…Abstract Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is associated with high morbidity and mortality. Although IMD incidence is…”
Get full text

Population genomics of post-vaccine changes in pneumococcal epidemiology by Croucher, Nicholas J, Finkelstein, Jonathan A, Pelton, Stephen I, Mitchell, Patrick K, Lee, Grace M, Parkhill, Julian, Bentley, Stephen D, Hanage, William P, Lipsitch, Marc

“…Nicholas Croucher and colleagues report whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae , a major cause of pneumonia,…”
Get full text

Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine by Yildirim, Inci, MD, MSc, Shea, Kimberly M., PhD, MPH, Pelton, Stephen I., MD

“…Universal immunization of infants and toddlers with pneumococcal conjugate vaccines over the last 15 years has dramatically altered the landscape of…”
Get full text

Modelling the population-level benefits and cost-effectiveness of cell-based quadrivalent influenza vaccine for children and adolescents aged 6 months to 17 years in the US by Pelton, Stephen I, Mould-Quevedo, Joaquin F, Nguyen, Van Hung

“…Cell-based quadrivalent influenza vaccines (QIVc) can increase effectiveness against seasonal influenza by avoiding mismatch from egg adaption of vaccine…”
Get full text

Direct and Indirect Effects of PCV13 on Nasopharyngeal Carriage of PCV13 Unique Pneumococcal Serotypes in Massachusetts’ Children by Loughlin, Anita M, Hsu, Katherine, Silverio, Amy L, Marchant, Colin D, Pelton, Stephen I

“…BACKGROUND:The direct impact of 13-valent pneumococcal conjugate vaccine (PCV13) on colonization with unique PCV13 serotypes and the uptake of vaccine…”
Get full text

Risk of exacerbation following pneumonia in adults with heart failure or chronic obstructive pulmonary disease by Bornheimer, Rebecca, Shea, Kimberly M, Sato, Reiko, Weycker, Derek, Pelton, Stephen I

“…Recent evidence demonstrates increased short-term risk of cardiac complications and respiratory failure among patients with heart failure (HF) and chronic…”
Get full text

Continued Impact of Pneumococcal Conjugate Vaccine on Carriage in Young Children by Huang, Susan S, Hinrichsen, Virginia L, Stevenson, Abbie E, Rifas-Shiman, Sheryl L, Kleinman, Ken, Pelton, Stephen I, Lipsitch, Marc, Hanage, William P, Lee, Grace M, Finkelstein, Jonathan A

“…The goals were to assess serial changes in Streptococcus pneumoniae serotypes and antibiotic resistance in young children and to evaluate whether risk factors…”
Get full text

A clinical and economic assessment of adjuvanted trivalent versus standard egg-derived quadrivalent influenza vaccines among older adults in the United States during the 2018-19 and 2019-20 influenza seasons by Levin, Myron J, Divino, Victoria, Postma, Maarten J, Pelton, Stephen I, Zhou, Zifan, DeKoven, Mitch, Mould-Quevedo, Joaquin

“…Clinical evidence supports use of enhanced influenza vaccines in older adults. Few economic outcome studies have compared adjuvanted trivalent inactivated…”
Get full text

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens by Cywes-Bentley, Colette, Skurnik, David, Zaidi, Tanweer, Roux, Damien, Deoliveira, Rosane B, Garrett, Wendy S, Lu, Xi, O'Malley, Jennifer, Kinzel, Kathryn, Zaidi, Tauqeer, Rey, Astrid, Perrin, Christophe, Fichorova, Raina N, Kayatani, Alexander K K, Maira-Litràn, Tomas, Gening, Marina L, Tsvetkov, Yury E, Nifantiev, Nikolay E, Bakaletz, Lauren O, Pelton, Stephen I, Golenbock, Douglas T, Pier, Gerald B

“…Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple…”
Get full text

Vaccination, underlying comorbidities, and risk of invasive pneumococcal disease by Yildirim, Inci, Shea, Kimberly M, Little, Brent A, Silverio, Amy L, Pelton, Stephen I

“…Children with underlying conditions remain at increased risk for invasive pneumococcal diseases (IPD). This study describes the epidemiology, serotype…”
Get full text

Serotype epidemiology and antibiotic resistance of pneumococcal isolates colonizing infants in Botswana (2016-2019) by Hurst, Jillian H, Shaik-Dasthagirisaheb, Yazdani B, Truong, Loc, Boiditswe, Sefelani C, Patel, Sweta M, Gilchrist, Jodi, Maciejewski, Julia, Luinstra, Kathy, Smieja, Marek, Steenhoff, Andrew P, Cunningham, Coleen K, Pelton, Stephen I, Kelly, Matthew S

“…In 2012, Botswana introduced 13-valent pneumococcal conjugate vaccine (PCV-13) to its childhood immunization program in a 3+0 schedule, achieving coverage…”
Get full text

Relative vaccine effectiveness of MF59-adjuvanted vs high-dose trivalent inactivated influenza vaccines for prevention of test-confirmed influenza hospitalizations during the 2017–2020 influenza seasons by McGovern, Ian, Chastek, Benjamin, Bancroft, Tim, Webb, Noah, Imran, Mahrukh, Pelton, Stephen I., Haag, Mendel D.M.

“…•Older adults have reduced response to vaccination with standard influenza vaccines.•Adjuvanted (aTIV) or high-dose (HD-TIV) influenza vaccines improve…”
Get full text

Otitis media and its consequences: beyond the earache by Vergison, Anne, MD, Dagan, Ron, MD, Arguedas, Adriano, MD, Bonhoeffer, Jan, MD, Cohen, Robert, MD, DHooge, Ingeborg, MD, Hoberman, Alejandro, MD, Liese, Johannes, MD, Marchisio, Paola, MD, Palmu, Arto A, MD, Ray, G Thomas, MBA, Sanders, Elisabeth AM, MD, Simões, Eric AF, MD, Uhari, Matti, MD, van Eldere, Johan, MD, Pelton, Stephen I, MD

“…Summary An international group of multidisciplinary experts on middle-ear and paediatric infections met to explore where consensus exists on the management of…”
Get full text

Vaccine Effectiveness of Cell-Based Quadrivalent Influenza Vaccine in Children: A Narrative Review by Mould-Quevedo, Joaquin F., Pelton, Stephen I., Nguyen, Van Hung

“…Cell-based manufacturing of seasonal influenza vaccines eliminates the risk of egg-adaptation of candidate vaccine viruses, potentially increasing vaccine…”
Get full text

The Impact of Adjuvanted Influenza Vaccine on Disease Severity in the US: A Stochastic Model by Pelton, Stephen I, Mould-Quevedo, Joaquin F, Nguyen, Van Hung

“…Influenza can exacerbate underlying medical conditions. In this study, we modelled the potential impact of an egg-based quadrivalent influenza vaccine (QIVe)…”
Get full text

The economic rationale for cell-based influenza vaccines in children and adults: A review of cost-effectiveness analyses by Fisman, David, Giglio, Norberto, Levin, Myron J, Nguyen, Van Hung, Pelton, Stephen I, Postma, Maarten, Ruiz-Aragón, Jesús, Urueña, Analia, Mould-Quevedo, Joaquin F

“…Seasonal influenza significantly affects both health and economic costs in children and adults. This narrative review summarizes published cost-effectiveness…”
Get full text

Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine by Patel, Sweta M, Shaik-Dasthagirisaheb, Yazdani B, Congdon, Morgan, Young, Rebecca R, Patel, Mohamed Z, Mazhani, Tiny, Boiditswe, Sefelani, Leburu, Tirayaone, Lechiile, Kwana, Arscott-Mills, Tonya, Steenhoff, Andrew P, Feemster, Kristen A, Shah, Samir S, Cunningham, Coleen K, Pelton, Stephen I, Kelly, Matthew S

“…Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase…”
Get full text

Effectiveness and impact of the 10-valent pneumococcal conjugate vaccine, PHiD-CV: review of clinical trials and post-marketing experience by Mrkvan, Tomas, Pelton, Stephen I, Ruiz-Guiñazú, Javier, Palmu, Arto A, Borys, Dorota

“…Pneumococcal diseases (including septicemia, meningitis, pneumonia, and upper respiratory infections) constitute a major public health problem. The World…”
Get full text

Editorial: Otitis media by Mason, Kevin M, Marsh, Robyn L, Pelton, Stephen I, Harvill, Eric T

Get full text

Immunogenicity and safety of MenACWY-TT, a quadrivalent meningococcal tetanus toxoid conjugate vaccine recently licensed in the United States for individuals ≥2 years of age by Marshall, Gary S., Pelton, Stephen I., Robertson, Corwin A., Oster, Philipp

“…Vaccination offers the best way to prevent invasive meningococcal disease (IMD). As demonstrated in countries with national immunization programs (NIPs)…”
Get full text