Search Results - "PELTON, S. I"

Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease by Yildirim, Inci, Hanage, William P, Lipsitch, Marc, Shea, Kimberly M, Stevenson, Abbie, Finkelstein, Jonathan, Huang, Susan S, Lee, Grace M, Kleinman, Ken, Pelton, S.I

“…Abstract Defining the propensity of Streptococcus pneumoniae (SP) serotypes to invade sterile body sites following nasopharyngeal (NP) acquisition has the…”
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Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae by Figueira, M, Fernandes, P, Pelton, S I

“…Solithromycin (CEM-101) is a "fourth-generation" macrolide, as it has three binding site and is acid stable. The three binding sites confer activity against…”
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Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness by Yildirim, I, Little, B.A, Finkelstein, J, Lee, G, Hanage, W.P, Shea, K, Pelton, S.I

“…Abstract Background Following the introduction of pneumococcal conjugate vaccines (PCV), overall nasopharyngeal colonization rates have not changed…”
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Clonal replacement among 19A Streptococcus pneumoniae in Massachusetts, prior to 13 valent conjugate vaccination by Hanage, W.P, Bishop, C.J, Lee, G.M, Lipsitch, M, Stevenson, A, Rifas-Shiman, S.L, Pelton, S.I, Huang, S.S, Finkelstein, J.A

“…Highlights ► Long-term ongoing study of PCV-7 impact on pneumococcal population structure using MLST. ► Multiply resistant 19A clone ST 320 replacing…”
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Modeling the decline in pneumococcal acute otitis media following the introduction of pneumococcal conjugate vaccines in the US by Shea, K.M, Weycker, D, Stevenson, A.E, Strutton, D.R, Pelton, S.I

“…Highlights ► We hypothesized serotype replacement has resulted in fewer episodes of SP-AOM. ► We modeled the change in proportion of SP colonized children who…”
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Streptococcus pneumoniae Serotype 6C: an Intra- and Interclonal Complex Comparison by THOMAS, J. C, KONG, Y, SABHARWAL, V, PELTON, S. I, PETTIGREW, M. M

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Do community-level predictors of pneumococcal carriage continue to play a role in the conjugate vaccine era? by HSU, K. K., RIFAS-SHIMAN, S. L., SHEA, K. M., KLEINMAN, K. P., LEE, G. M., LAKOMA, M., PELTON, S. I., FINKELSTEIN, J. A., HUANG, S. S.

“…This paper examined whether previously identified community-level factors (high proportion of crowded households and/or persons below the poverty level)…”
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Serotype 15C Streptococcus pneumoniae resistant to classical complement deposition and agglutination by polyclonal rabbit anti-capsular 15B sera by Kochis, E.J., Shaik-Dasthagirisaheb, Y.B., Munarriz, N., Kretzmann, I., Nahm, M., Pelton, S.I., Lapidot, R.

“…S. pneumoniae (SP) serotypes 15B and 15C are frequent causative agents of invasive pneumococcal disease (IPD), otitis media, and nasopharyngeal colonization in…”
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Parents, Physicians, and Antibiotic Use by Bauchner, Howard, Pelton, Stephen I, Klein, Jerome O

“…Emergence of resistant bacterial pathogens has increased concerns about antibiotic prescribing patterns. Parent expectations and pressure may influence these…”
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Differential Narrow Focusing of Immunodominant Human Immunodeficiency Virus Gag-Specific Cytotoxic T-Lymphocyte Responses in Infected African and Caucasoid Adults and Children by Goulder, P J, Brander, C, Annamalai, K, Mngqundaniso, N, Govender, U, Tang, Y, He, S, Hartman, K E, O'Callaghan, C A, Ogg, G S, Altfeld, M A, Rosenberg, E S, Cao, H, Kalams, S A, Hammond, M, Bunce, M, Pelton, S I, Burchett, S A, McIntosh, K, Coovadia, H M, Walker, B D

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Efficacy of Linezolid in Experimental Otitis Media by PELTON, S. I, FIGUEIRA, M, ALBUT, R, STALKER, D

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Otoscopy for the diagnosis of otitis media by PELTON, STEPHEN I

“…The diagnosis of acute otitis media (AOM) is neither easy nor straightforward. Signs and symptoms of upper respiratory illness overlap with AOM. Fever,…”
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Improving the outcome of pneumococcal meningitis by Pelton, S I, Yogev, R

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Impact of 13-Valent Pneumococcal Conjugate Vaccination on Streptococcus pneumoniae Carriage in Young Children in Massachusetts by Lee, Grace M., Kleinman, Ken, Pelton, Stephen I., Hanage, William, Huang, Susan S., Lakoma, Matthew, Dutta-Linn, Maya, Croucher, Nicholas J., Stevenson, Abbie, Finkelstein, Jonathan A.

“…Background In April 2010, a 13-valent pneumococcal conjugate vaccine (PCV13) replaced PCV7 for use in the United States. We evaluated rates of pneumococcal…”
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Otitis media across nine countries: Disease burden and management by Arguedas, A, Kvaerner, K, Liese, J, Schilder, A.G.M, Pelton, S.I

“…Abstract Objective To assess the perceived disease burden and management of otitis media (OM) among an international cohort of experienced physicians. Methods…”
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Constancy of Distribution of Serogroups of Invasive Pneumococcal Isolates Among Children: Experience during 4 Decades by Babl, Franz E., Pelton, Steven I., Theodore, Sam, Klein, Jerome O.

“…Serogroups of pneumococci that caused bacteremia or meningitis in children were examined from 1981 through 1998 at Boston City Hospital/Boston Medical Center…”
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Abnormal body-fat distribution in HIV-1-infected children on antiretrovirals by Babl, Franz E, Regan, Anne Marie, Pelton, Stephen I

“…An increasing number of HIV-1-infected children are being given protease inhibitors, but little is known about the prevalence and risk factors of abnormal…”
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Variability of Outer Membrane Protein P1 and Its Evaluation as a Vaccine Candidate against Experimental Otitis Media due to Nontypeable Haemophilus influenzae: an Unambiguous, Multifaceted Approach by BOLDUC, G. R, BOUCHET, V, JIANG, R.-Z, GEISSELSODER, J, TRUONG-BOLDUC, Q. C, RICE, P. A, PELTON, S. I, GOLDSTEIN, R

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Management of the Young Febrile Child: A Continuing Controversy by Bauchner, Howard, Pelton, Stephen I

“…A criticism of practice guidelines for treating feverish children may be as extreme as the guidelines themselves. The guidelines recommend aggressively testing…”
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The promise of immunoprophylaxis for prevention of acute otitis media by PELTON, STEPHEN I, KLEIN, JEROME O

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