Search Results - "PELLETT, Jackson D."

Impact of Food and the Proton Pump Inhibitor Rabeprazole on the Pharmacokinetics of GDC-0941 in Healthy Volunteers: Bench to Bedside Investigation of pH-Dependent Solubility by Ware, Joseph A, Dalziel, Gena, Jin, Jin Y, Pellett, Jackson D, Smelick, Gillian S, West, David A, Salphati, Laurent, Ding, Xiao, Sutton, Rebecca, Fridyland, Jane, Dresser, Mark J, Morrisson, Glenn, Holden, Scott N

“…GDC-0941 is an orally administered potent, selective pan-inhibitor of phosphatidylinositol 3-kinases (PI3Ks) with good preclinical antitumor activity in…”
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Predicting Long-Term Stability of an Oral Delivered Antibody Drug Product with Accelerated Stability Assessment Program Modeling by Dai, Lulu, Davis, Jeff, Nagapudi, Karthik, Mantik, Priscilla, Zhang, Kelly, Pellett, Jackson D., Wei, Bingchuan

“…The oral delivery of protein therapeutics offers numerous advantages for patients but also presents significant challenges in terms of development. Currently,…”
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Scaling laws for nanoparticles – Online shape heterogeneity analysis by size exclusion chromatography coupled with multi-angle light scattering by Tang, Shijia, Levy, Elizabeth S., Zang, Nanzhi, Goyon, Alexandre, Chang, Debby, Cebrero, Abigail, Tang, Yijing, Pellett, Jackson D.

“…•SEC method for separation of liposomes and lipodisks.•Nanoparticle shape heterogeneity analysis by scaling law of Rg vs. MW.•A semi-quantitative model to…”
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Deep eutectic solvents as green and sustainable diluents in headspace gas chromatography for the determination of trace level genotoxic impurities in pharmaceuticals by Abbasi, Nabeel Mujtaba, Anderson, Jared L., Pellett, Jackson D., Yehl, Peter M., del Barrio, Mary-Anne, Zhong, Qiqing

“…Genotoxic impurities (GTIs) are potential carcinogens that need to be controlled down to ppm or lower concentration levels in pharmaceuticals under strict…”
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Label-Free Composition Analysis of Supramolecular Polymer–Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector by Tang, Shijia, Pederson, Zachary, Meany, Emily L., Yen, Chun-Wan, Swansiger, Andrew K., Prell, James S., Chen, Bifan, Grosskopf, Abigail K., Eckman, Noah, Jiang, Grace, Baillet, Julie, Pellett, Jackson D., Appel, Eric A.

“…Supramolecular hydrogels formed through polymer–nanoparticle interactions are promising biocompatible materials for translational medicines. This class of…”
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Loss on Drying Using Halogen Moisture Analyzer: An Orthogonal Technique for Monitoring Volatile Content for In-Process Control Samples during Pharmaceutical Manufacturing by Razvi, Sayyeda Zeenat A, Kamm, Isabelle, Nguyen, Tina, Pellett, Jackson D, Kumar, Archana

“…Organic solvents and water are routinely used during the synthetic pathway of an active pharmaceutical ingredient (API) and extraction work up, respectively…”
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Deep eutectic solvents as green and sustainable diluents in headspace gas chromatography for the determination of trace level genotoxic impurities in pharmaceuticals by Abbasi, Nabeel Mujtaba, Anderson, Jared L., Pellett, Jackson D., Yehl, Peter M., del Barrio, Mary-Anne, Zhong, Qiqing

“…Genotoxic impurities (GTIs) are potential carcinogens that need to be controlled down to ppm or lower concentration levels in pharmaceuticals under strict…”
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Role of Aromatic Stacking Interactions in the Modulation of the Two-Electron Reduction Potentials of Flavin and Substrate/Product in Megasphaera elsdenii Short-Chain Acyl-Coenzyme A Dehydrogenase by Pellett, Jackson D, Becker, Donald F, Saenger, Amy K, Fuchs, James A, Stankovich, Marian T

“…The effects of aromatic stacking interactions on the stabilization of reduced flavin adenine dinucleotide (FAD) and substrate/product have been investigated in…”
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Reactive impurities in large and small molecule pharmaceutical excipients – A review by Zhang, Kelly, Pellett, Jackson D., Narang, Ajit S., Wang, Y. John, Zhang, Yonghua Taylor

“…Reactive impurities in excipients can cause drug product degradation or protein modification even at trace levels, and thus impact drug stability and quality…”
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Medium-Chain Acyl-Coenzyme A Dehydrogenase Bound to a Product Analogue, Hexadienoyl-Coenzyme A:  Effects on Reduction Potential, pK a, and Polarization by Pellett, Jackson D, Sabaj, Kim Marie, Stephens, Avery W, Bell, Alasdair F, Wu, Jiaquan, Tonge, Peter J, Stankovich, Marian T

“…2,4-Hexadienoyl-coenzyme A (HD-CoA) has been used to investigate the redox and ionization properties of medium-chain acyl-CoA dehydrogenase (MCAD) from pig…”
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Medium-Chain Acyl-Coenzyme A Dehydrogenase Bound to a Product Analogue, Hexadienoyl-Coenzyme A:  Effects on Reduction Potential, p K a , and Polarization by Pellett, Jackson D., Sabaj, Kim Marie, Stephens, Avery W., Bell, Alasdair F., Wu, Jiaquan, Tonge, Peter J., Stankovich, Marian T.

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Medium-Chain Acyl-Coenzyme A Dehydrogenase Bound to a Product Analogue, Hexadienoyl-Coenzyme A:  Effects on Reduction Potential, pKa, and Polarization by PELLETT, Jackson D., SABAJ, Kim Marie, STEPHENS, Avery W., BELL, Alasdair F., WU, Jiaquan, TONGE, Peter J., STANKOVICH, Marian T.

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GMPs for Small-Molecule Drugs in Early Development: Workshop Summary-Part VI by Li, Q Chan, Pellett, Jackson D, Szulc, Michael, Trone, Mark D, Wong-Moon, Kirby

“…The International Consortium on Innovation and Quality in Pharmaceutical Development (IQ Consortium) is a technically focused organization of pharmaceutical…”
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Part VII: GMPs for small-molecule drugs in early development--workshop summary: the authors explore and define common industry approaches and practices when applying GMPs in early development by Li, Q. Chan, Pellett, Jackson D, Szulc, Michael, Trone, Mark D, Wong-Moon, Kirby

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GMPs for small-molecule drugs in early development: workshop summary--Part VI: the authors explore and define common industry approaches and practices when applying GMPs in early development by Li, Q. Chan, Pellett, Jackson D, Szulc, Michael, Trone, Mark D, Wong-Moon, Kirby

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