Search Results - "PELLAGATTI, Andrea"

The molecular pathogenesis of the myelodysplastic syndromes by Pellagatti, Andrea, Boultwood, Jacqueline

“…Recent studies have greatly illuminated the genomic landscape of the myelodysplastic syndromes (MDS), and the pace of discovery is accelerating. The most…”
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U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies by Smith, Molly A., Choudhary, Gaurav S., Pellagatti, Andrea, Choi, Kwangmin, Bolanos, Lyndsey C., Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Von Ahrens, Dagny, Pradhan, Kith, Steeples, Violetta, Kim, Sanghyun, Steidl, Ulrich, Walter, Matthew, Fraser, Iain D. C., Kulkarni, Aishwarya, Salomonis, Nathan, Komurov, Kakajan, Boultwood, Jacqueline, Verma, Amit, Starczynowski, Daniel T.

“…Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have…”
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Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications by Pellagatti, Andrea, Boultwood, Jacqueline

“…Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid malignancy myelodysplastic syndrome (MDS), suggesting that…”
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IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells by Schinke, Carolina, Giricz, Orsolya, Li, Weijuan, Shastri, Aditi, Gordon, Shanisha, Barreyro, Laura, Bhagat, Tushar, Bhattacharyya, Sanchari, Ramachandra, Nandini, Bartenstein, Matthias, Pellagatti, Andrea, Boultwood, Jacqueline, Wickrema, Amittha, Yu, Yiting, Will, Britta, Wei, Sheng, Steidl, Ulrich, Verma, Amit

“…Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional…”
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SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications by Singh, Shalini, Ahmed, Doaa, Dolatshad, Hamid, Tatwavedi, Dharamveer, Schulze, Ulrike, Sanchi, Andrea, Ryley, Sarah, Dhir, Ashish, Carpenter, Lee, Watt, Suzanne M., Roberts, David J., Abdel-Aal, Amal M., Sayed, Sohair K., Mohamed, Somaia A., Schuh, Anna, Vyas, Paresh, Killick, Sally, Kotini, Andriana G., Papapetrou, Eirini P., Wiseman, Daniel H., Pellagatti, Andrea, Boultwood, Jacqueline

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Application of CRISPR/Cas9 genome editing to the study and treatment of disease by Pellagatti, Andrea, Dolatshad, Hamid, Valletta, Simona, Boultwood, Jacqueline

“…CRISPR/Cas is a microbial adaptive immune system that uses RNA-guided nucleases to cleave foreign genetic elements. The CRISPR/Cas9 method has been engineered…”
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Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow by Gerlevik, Sila, Seymen, Nogayhan, Hama, Shan, Mumtaz, Warisha, Thompson, I Richard, Jalili, Seyed R, Kaya, Deniz E, Iacoangeli, Alfredo, Pellagatti, Andrea, Boultwood, Jacqueline, Napolitani, Giorgio, Mufti, Ghulam J, Karimi, Mohammad M

“…Mutational profiles of myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2…”
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Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline by Hennrich, Marco L., Romanov, Natalie, Horn, Patrick, Jaeger, Samira, Eckstein, Volker, Steeples, Violetta, Ye, Fei, Ding, Ximing, Poisa-Beiro, Laura, Lai, Mang Ching, Lang, Benjamin, Boultwood, Jacqueline, Luft, Thomas, Zaugg, Judith B., Pellagatti, Andrea, Bork, Peer, Aloy, Patrick, Gavin, Anne-Claude, Ho, Anthony D.

“…Diminishing potential to replace damaged tissues is a hallmark for ageing of somatic stem cells, but the mechanisms remain elusive. Here, we present…”
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ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine by Rahmani, Nora E., Ramachandra, Nandini, Sahu, Srabani, Gitego, Nadege, Lopez, Andrea, Pradhan, Kith, Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Pena, Bianca Rivera, Kazemi, Mohammad, Rao, Keshav, Giricz, Orsi, Maqbool, Shahina Bano, Olea, Raul, Zhao, Yongmei, Zhang, Jinghang, Dolatshad, Hamid, Tittrea, Vickram, Tatwavedi, Dharamveer, Singh, Shalini, Lee, Juseong, Sun, Tianyu, Steidl, Ulrich, Shastri, Aditi, Inoue, Daichi, Abdel-Wahab, Omar, Pellagatti, Andrea, Gavathiotis, Evripidis, Boultwood, Jacqueline, Verma, Amit

“…The BCL2-inhibitor, Venetoclax (VEN), has shown significant anti-leukemic efficacy in combination with the DNMT-inhibitor, Azacytidine (AZA). To explore the…”
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SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function by Sun, Jie, He, Xin, Zhu, Yinghui, Ding, Zonghui, Dong, Haojie, Feng, Yimei, Du, Juan, Wang, Hanying, Wu, Xiwei, Zhang, Lei, Yu, Xiaochun, Lin, Allen, McDonald, Tinisha, Zhao, Dandan, Wu, Herman, Hua, Wei-Kai, Zhang, Bin, Feng, Lifeng, Tohyama, Kaoru, Bhatia, Ravi, Oberdoerffer, Philipp, Chung, Yang Jo, Aplan, Peter D., Boultwood, Jacqueline, Pellagatti, Andrea, Khaled, Samer, Kortylewski, Marcin, Pichiorri, Flavia, Kuo, Ya-Huei, Carlesso, Nadia, Marcucci, Guido, Jin, Hongchuan, Li, Ling

“…Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that…”
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Gene expression and risk of leukemic transformation in myelodysplasia by Shiozawa, Yusuke, Malcovati, Luca, Gallì, Anna, Pellagatti, Andrea, Karimi, Mohsen, Sato-Otsubo, Aiko, Sato, Yusuke, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Shiraishi, Yuichi, Chiba, Kenichi, Makishima, Hideki, Boultwood, Jacqueline, Hellström-Lindberg, Eva, Miyano, Satoru, Cazzola, Mario, Ogawa, Seishi

“…Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic disorders with a highly variable prognosis. To identify a gene…”
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Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability by Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul

“…Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of…”
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Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations by Will, Britta, Zhou, Li, Vogler, Thomas O., Ben-Neriah, Susanna, Schinke, Carolina, Tamari, Roni, Yu, Yiting, Bhagat, Tushar D., Bhattacharyya, Sanchari, Barreyro, Laura, Heuck, Christoph, Mo, Yonkai, Parekh, Samir, McMahon, Christine, Pellagatti, Andrea, Boultwood, Jacqueline, Montagna, Cristina, Silverman, Lewis, Maciejewski, Jaroslaw, Greally, John M., Ye, B. Hilda, List, Alan F., Steidl, Christian, Steidl, Ulrich, Verma, Amit

“…Even though hematopoietic stem cell (HSC) dysfunction is presumed in myelodysplastic syndrome (MDS), the exact nature of quantitative and qualitative…”
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Advances in the 5q− syndrome by Boultwood, Jacqueline, Pellagatti, Andrea, McKenzie, Andrew N.J., Wainscoat, James S.

“…The 5q− syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The significant progress made during…”
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Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes by Follo, Matilde Y., Pellagatti, Andrea, Armstrong, Richard N., Ratti, Stefano, Mongiorgi, Sara, De Fanti, Sara, Bochicchio, Maria Teresa, Russo, Domenico, Gobbi, Marco, Miglino, Maurizio, Parisi, Sarah, Martinelli, Giovanni, Cavo, Michele, Luiselli, Donata, McCubrey, James A., Suh, Pann-Ghill, Manzoli, Lucia, Boultwood, Jacqueline, Finelli, Carlo, Cocco, Lucio

“…Specific myeloid-related and inositide-specific gene mutations can be linked to myelodysplastic syndromes (MDS) pathogenesis and therapy. Here, 44 higher-risk…”
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Recent Advances in the 5q- Syndrome by Pellagatti, Andrea, Boultwood, Jacqueline

“…The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this disorder have a deletion of chromosome 5q [del(5q)] as the…”
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Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS by Barreyro, Laura, Will, Britta, Bartholdy, Boris, Zhou, Li, Todorova, Tihomira I., Stanley, Robert F., Ben-Neriah, Susana, Montagna, Cristina, Parekh, Samir, Pellagatti, Andrea, Boultwood, Jacqueline, Paietta, Elisabeth, Ketterling, Rhett P., Cripe, Larry, Fernandez, Hugo F., Greenberg, Peter L., Tallman, Martin S., Steidl, Christian, Mitsiades, Constantine S., Verma, Amit, Steidl, Ulrich

“…Cellular and interpatient heterogeneity and the involvement of different stem and progenitor compartments in leukemogenesis are challenges for the…”
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Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes by Yip, Bon Ham, Dolatshad, Hamid, Roy, Swagata, Pellagatti, Andrea, Boultwood, Jacqueline

“…Splicing is an essential cellular process which is carried out by the spliceosome in order to remove the introns and join the exons present in pre-mRNA…”
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Phospholipase C beta1 (PI‐PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron‐induced oxidative stress in myelodysplastic syndromes (MDS) by Cappellini, Alessandra, Mongiorgi, Sara, Finelli, Carlo, Fazio, Antonietta, Ratti, Stefano, Marvi, Maria Vittoria, Curti, Antonio, Salvestrini, Valentina, Pellagatti, Andrea, Billi, Anna Maria, Suh, Pann‐Ghill, McCubrey, James A., Boultwood, Jacqueline, Manzoli, Lucia, Cocco, Lucio, Follo, Matilde Y.

“…MDS are characterized by anemia and transfusion requirements. Transfused patients frequently show iron overload that negatively affects hematopoiesis. Iron…”
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ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts by Valletta, Simona, Dolatshad, Hamid, Bartenstein, Matthias, Yip, Bon Ham, Bello, Erica, Gordon, Shanisha, Yu, Yiting, Shaw, Jacqueline, Roy, Swagata, Scifo, Laura, Schuh, Anna, Pellagatti, Andrea, Fulga, Tudor A, Verma, Amit, Boultwood, Jacqueline

“…Recurrent somatic mutations of the epigenetic modifier and tumor suppressor ASXL1 are common in myeloid malignancies, including chronic myeloid leukemia (CML),…”
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