Search Results - "PELICANO, Hélène"

Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential by Pelicano, Hélène, Zhang, Wan, Liu, Jinyun, Hammoudi, Naima, Dai, Jiale, Xu, Rui-Hua, Pusztai, Lajos, Huang, Peng

“…Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. TNBC is not amenable to endocrine therapy and often…”
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Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism by Pelicano, Hélène, Xu, Rui-hua, Du, Min, Feng, Li, Sasaki, Ryohei, Carew, Jennifer S, Hu, Yumin, Ramdas, Latha, Hu, Limei, Keating, Michael J, Zhang, Wei, Plunkett, William, Huang, Peng

“…Cancer cells exhibit increased glycolysis for ATP production due, in part, to respiration injury (the Warburg effect). Because ATP generation through…”
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Simultaneous inhibition of PDK1/AKT and fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia by ZHIHONG ZENG, SAMUDIO, Ismael J, PENG HUANG, YILING LU, MILLS, Gordon B, ANDREEFF, Michael, KONOPLEVA, Marina, WEIGUO ZHANG, ESTROV, Zeev, PELICANO, Hélène, HARRIS, David, FROLOVA, Olga, HAIL, Numsen, WENJING CHEN, KORNBLAU, Steven M

“…Phosphoinositol-3-kinase (PI3K)/protein kinase B (AKT) and Fms-like tyrosine kinase 3 (FLT3) signaling are aberrantly activated in acute myelogenous leukemia…”
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Resistance of chronic lymphocytic leukemia cells in apoptosis: key role of stromal cells in maintaining the redox potential of CLL cells by Zhang, Wan, Feng, Li, Pelicano, Hélène, Huang, Peng

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Cancer Metabolism: Is Glutamine Sweeter than Glucose? by Lu, Weiqin, Pelicano, Helene, Huang, Peng

“…Glutamine is an essential nutrient for cancer cells. In this issue of Cancer Cell, Wang et al. (2010) show that malignant transformation by Rho GTPases leads…”
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ROS stress in cancer cells and therapeutic implications by Pelicano, Helene, Carney, Dennis, Huang, Peng

“…Reactive oxygen species (ROS) are constantly generated and eliminated in the biological system, and play important roles in a variety of normal biochemical…”
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Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer by Liu, Junchen, Chen, Guo, Liu, Zezhen, Liu, Shaoyou, Cai, Zhiduan, You, Pan, Ke, Yuepeng, Lai, Li, Huang, Yun, Gao, Hongchang, Zhao, Liangcai, Pelicano, Helene, Huang, Peng, McKeehan, Wallace L, Wu, Chin-Lee, Wang, Cong, Zhong, Weide, Wang, Fen

“…The acquisition of ectopic fibroblast growthfactor receptor 1 (FGFR1) expression is well documented in prostate cancer progression. How it contributes to…”
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Novel action of paclitaxel against cancer cells : Bystander effect mediated by reactive oxygen species by ALEXANDRE, Jérome, YUMIN HU, WEIQIN LU, PELICANO, Helene, PENG HUANG

“…Generation of reactive oxygen species (ROS) has been observed in cancer cells treated with paclitaxel, but the underlying mechanisms and therapeutic…”
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Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism by PELICANO, Helene, WEIQIN LU, YAN ZHOU, WAN ZHANG, ZHAO CHEN, YUMIN HU, PENG HUANG

“…Although mitochondrial dysfunction and reactive oxygen species (ROS) stress have long been observed in cancer cells, their role in promoting malignant cell…”
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Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression by Chen, Dong-Liang, Ju, Huai-Qiang, Lu, Yun-Xin, Chen, Le-Zong, Zeng, Zhao-Lei, Zhang, Dong-Sheng, Luo, Hui-Yan, Wang, Feng, Qiu, Miao-Zhen, Wang, De-Shen, Xu, Da-Zhi, Zhou, Zhi-Wei, Pelicano, Helene, Huang, Peng, Xie, Dan, Wang, Feng-Hua, Li, Yu-Hong, Xu, Rui-Hua

“…Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the role and molecular mechanism of lncRNA XIST in gastric…”
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Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy by Lu, Weiqin, Hu, Yumin, Chen, Gang, Chen, Zhao, Zhang, Hui, Wang, Feng, Feng, Li, Pelicano, Helene, Wang, Hua, Keating, Michael J, Liu, Jinsong, McKeehan, Wallace, Wang, Huamin, Luo, Yongde, Huang, Peng

“…Elevated aerobic glycolysis in cancer cells (the Warburg effect) may be attributed to respiration injury or mitochondrial dysfunction, but the underlying…”
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Identification of MicroRNA‐214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression by Chen, Dong‐liang, Wang, Zhi‐qiang, Zeng, Zhao‐lei, Wu, Wen‐jing, Zhang, Dong‐sheng, Luo, Hui‐yan, Wang, Feng, Qiu, Miao‐zhen, Wang, De‐shen, Ren, Chao, Wang, Feng‐hua, Chiao, Lucia J., Pelicano, Helene, Huang, Peng, Li, Yu‐hong, Xu, Rui‐hua

“…The purpose of this study was to identify microRNAs (miRNAs) involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their…”
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Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway by Honeychurch, Jamie, Alduaij, Waleed, Azizyan, Mahsa, Cheadle, Eleanor J., Pelicano, Helene, Ivanov, Andrei, Huang, Peng, Cragg, Mark S., Illidge, Tim M.

“…Monoclonal antibodies (mAbs) have revolutionized the treatment of B-cell malignancies. Although Fc-dependent mechanisms of mAb-mediated tumor clearance have…”
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Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism by Trachootham, Dunyaporn, Zhang, Hui, Zhang, Wan, Feng, Li, Du, Min, Zhou, Yan, Chen, Zhao, Pelicano, Helene, Plunkett, William, Wierda, William G., Keating, Michael J., Huang, Peng

“…Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, and resistance to fludarabine-based therapies is a major challenge in CLL treatment…”
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The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo by Fu, Loning, Pelicano, Helene, Liu, Jinsong, Huang, Peng, Lee, Cheng Chi

“…The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene are cancer prone. After γ…”
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Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications by Ju, Huai-Qiang, Lu, Yun-Xin, Chen, Dong-Liang, Tian, Tian, Mo, Hai-Yu, Wei, Xiao-Li, Liao, Jian-Wei, Wang, Feng, Zeng, Zhao-Lei, Pelicano, Helene, Aguilar, Mitzi, Jia, Wei-Hua, Xu, Rui-Hua

“…Colorectal cancer (CRC) is a common neoplastic disease and a frequent cause of death. Drug resistance is a major challenge to CRC treatment and stem-like…”
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microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer by Chen, Dong-liang, Zhang, Dong-sheng, Lu, Yun-xin, Chen, Le-zong, Zeng, Zhao-lei, He, Ming-ming, Wang, Feng-hua, Li, Yu-hong, Zhang, Hui-zhong, Pelicano, Helene, Zhang, Wei, Xu, Rui-hua

“…microRNA-217 (miR-217) is frequently dysregulated in cancer. Here, we report that miR-217 levels were lower in tumor tissue compared with the adjacent normal…”
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Correction: Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy by Lu, Weiqin, Hu, Yumin, Chen, Gang, Chen, Zhao, Zhang, Hui, Wang, Feng, Feng, Li, Pelicano, Helene, Wang, Hua, Keating, Michael J, Liu, Jinsong, McKeehan, Wallace, Wang, Huamin, Luo, Yongde, Huang, Peng

“…[This corrects the article DOI: 10.1371/journal.pbio.1001326.]…”
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Correction to: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression by Chen, Dong-liang, Ju, Huai-qiang, Lu, Yun-xin, Chen, Le-zong, Zeng, Zhao-lei, Zhang, Dong-sheng, Luo, Hui-yan, Wang, Feng, Qiu, Miao-zhen, Wang, De-shen, Xu, Da-zhi, Zhou, Zhi-wei, Pelicano, Helene, Huang, Peng, Xie, Dan, Wang, Feng-hua, Li, Yu-hong, Xu, Rui-hua

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A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis by Samudio, Ismael, Konopleva, Marina, Pelicano, Helene, Huang, Peng, Frolova, Olga, Bornmann, William, Ying, Yunming, Evans, Randall, Contractor, Rooha, Andreeff, Michael

“…Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me) is a synthetic oleanolic acid derivative that displays antitumorigenic and anti-inflammatory…”
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