Search Results - "PEIQING SUN"

Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence by Xu, Yingxi, Li, Na, Xiang, Rong, Sun, Peiqing

“…•Recent advances in OIS mechanisms are discussed.•The role of the p38 MAPK pathway in OIS is highlighted.•The role of the PI3K/AKT/mTOR pathway in OIS is…”
Get full text

The pathways to tumor suppression via route p38 by Han, Jiahuai, Sun, Peiqing

“…Besides its well-known functions in inflammation and other stresses, the p38 mitogen-activated protein kinase pathway also negatively regulates cell…”
Get full text

Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1 by Jiang, Huimin, Zhou, Chen, Zhang, Zhen, Wang, Qiong, Wei, Huimin, Shi, Wen, Li, Jianjun, Wang, Zhaoyang, Ou, Yang, Wang, Wenhao, Wang, Hang, Zhang, Quansheng, Sun, Wei, Sun, Peiqing, Yang, Shuang

“…Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it…”
Get full text

Simple Whole-Cell Biodetection and Bioremediation of Heavy Metals Based on an Engineered Lead-Specific Operon by Wei, Wei, Liu, Xiangzhi, Sun, Peiqing, Wang, Xin, Zhu, Hong, Hong, Mei, Mao, Zong-Wan, Zhao, Jing

“…A lead-specific binding protein, PbrR, and promoter pbr from the lead resistance operon, pbr, of Cupriavidus metallidurans CH34 was incorporated into E. coli…”
Get full text

Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1 by Zhao, Shaorong, Li, Jianjun, Zhang, Guomin, Wang, Qiong, Wu, Chao, Zhang, Quansheng, Wang, Hang, Sun, Peiqing, Xiang, Rong, Yang, Shuang

“…Emerging evidence suggests that exosomal microRNAs (miRNAs) mediate hepatoma progression through the post-translational regulation of their targets. However,…”
Get full text

ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM by Zhang, Xiang, Zhang, Zhen, Zhang, Qing, Zhang, Quansheng, Sun, Peiqing, Xiang, Rong, Ren, Guosheng, Yang, Shuang

“…Although zinc finger E-box binding homeobox 1 (ZEB1) has been identified as a key factor in the regulation of breast cancer differentiation and metastasis, its…”
Get full text

MZF1 mediates oncogene-induced senescence by promoting the transcription of p16INK4A by Wu, Dan, Tan, Hua, Su, Weijun, Cheng, Dongmei, Wang, Guanwen, Wang, Juan, Ma, Ding A., Dong, George M., Sun, Peiqing

“…Oncogene induced senescence is a tumor suppressing defense mechanism, in which the cell cycle-dependent protein kinase (CDK) inhibitor p16 INK4A (encoded by…”
Get full text

A surface-display biohybrid approach to light-driven hydrogen production in air by Wei, Wei, Sun, Peiqing, Li, Zhen, Song, Kuisong, Su, Wenyin, Wang, Bao, Liu, Yangzhong, Zhao, Jing

“…Solar-to-chemical production by artificial and bioinspired photosynthetic systems is of tremendous interest to help solve current global energy and…”
Get full text

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence by Kolesnichenko, Marina, Hong, Lixin, Liao, Rong, Vogt, Peter K., Sun, Peiqing

“…Numerous stimuli, including oncogenic signaling, DNA damage or eroded telomeres trigger proliferative arrest, termed cellular senescence. Accumulating evidence…”
Get full text

Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition by Wang, Juan, Wang, Guanwen, Cheng, Dongmei, Huang, Shan, Chang, Antao, Tan, Xiaoming, Wang, Qiong, Zhao, Shaorong, Wu, Dan, Liu, Andy T., Yang, Shuang, Xiang, Rong, Sun, Peiqing

“…Cancer can metastasize from early lesions without detectable tumors. Despite extensive studies on metastasis in cancer cells from patients with detectable…”
Get full text

CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism by Zhang, Zhen, Li, Jianjun, Ou, Yang, Yang, Guang, Deng, Kaiyuan, Wang, Qiong, Wang, Zhaoyang, Wang, Wenhao, Zhang, Quansheng, Wang, Hang, Sun, Wei, Sun, Peiqing, Yang, Shuang

“…Tumor metastasis is the most common cause of cancer-related deaths, yet it remains poorly understood. The transcription factor zinc-finger E-box binding…”
Get full text

Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2 by Wang, Guanwen, Wang, Juan, Chang, Antao, Cheng, Dongmei, Huang, Shan, Wu, Dan, Sirkisoon, Sherona, Yang, Shuang, Lin, Hui-Kuan, Lo, Hui-Wen, Xiang, Rong, Sun, Peiqing

“…While mechanisms for metastasis were extensively studied in cancer cells from patients with detectable tumors, pathways underlying metastatic dissemination…”
Get full text

The miR-17-92 Cluster of MicroRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence by LIXIN HONG, MAOYI LAI, CHEN, Michelle, CHANGCHUAN XIE, RONG LIAO, YOUNG JUN KANG, CHANGCHUN XIAO, HU, Wen-Yuan, JIAHUAI HAN, PEIQING SUN

“…In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, including apoptosis and senescence, which are…”
Get full text

A Novel CDK4/6 and PARP Dual Inhibitor ZC-22 Effectively Suppresses Tumor Growth and Improves the Response to Cisplatin Treatment in Breast and Ovarian Cancer by Tian, Chenchen, Wei, Yufan, Li, Jianjun, Huang, Zhi, Wang, Qiong, Lin, Yingxue, Lv, Xingping, Chen, Yanan, Fan, Yan, Sun, Peiqing, Xiang, Rong, Chang, Antao, Yang, Shuang

“…In recent years, three PARP inhibitors and three CDK4/6 inhibitors have been approved by the FDA for the treatment of recurrent ovarian cancer and advanced…”
Get full text

Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq by Song, Qianqian, Hawkins, Gregory A., Wudel, Leonard, Chou, Ping‐Chieh, Forbes, Elizabeth, Pullikuth, Ashok K., Liu, Liang, Jin, Guangxu, Craddock, Lou, Topaloglu, Umit, Kucera, Gregory, O’Neill, Stacey, Levine, Edward A., Sun, Peiqing, Watabe, Kounosuke, Lu, Yong, Alexander‐Miller, Martha A., Pasche, Boris, Miller, Lance D., Zhang, Wei

“…Tumor‐infiltrating myeloid cells are the most abundant leukocyte population within tumors. Molecular cues from the tumor microenvironment promote the…”
Get full text

The High-Risk HPV16 E7 Oncoprotein Mediates Interaction between the Transcriptional Coactivator CBP and the Retinoblastoma Protein pRb by Jansma, Ariane L., Martinez-Yamout, Maria A., Liao, Rong, Sun, Peiqing, Dyson, H. Jane, Wright, Peter E.

“…The oncoprotein E7 from human papillomavirus (HPV) strains that confer high cancer risk mediates cell transformation by deregulating host cellular processes…”
Get full text

Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway by Wang, Nan, Fang, Yan, Hou, Yigong, Cheng, Dongmei, Dressler, Emily V, Wang, Hao, Wang, Juan, Wang, Guanwen, Li, Yilei, Liu, Hong, Xiang, Rong, Yang, Shuang, Sun, Peiqing

“…Cellular senescence can be induced in mammalian tissues by multiple stimuli, including aging, oncogene activation and loss of tumor suppressor genes, and…”
Get full text

Ultrafast near-infrared pyroelectric detector based on inhomogeneous plasmonic metasurface by Lu, Youyan, Liu, Liyun, Gao, Ruoqian, Xiong, Ying, Sun, Peiqing, Wu, Zhanghao, Wu, Kai, Yu, Tong, Zhang, Kai, Zhang, Cheng, Bourouina, Tarik, Li, Xiaofeng, Liu, Xiaoyi

“…Pyroelectric (PE) detection technologies have attracted extensive attention due to the cooling-free, bias-free, and broadband properties. However, the PE…”
Get full text

WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC by Deng, Kaiyuan, Liu, Liang, Tan, Xiaoming, Zhang, Zhen, Li, Jianjun, Ou, Yang, Wang, Xin, Yang, Shuang, Xiang, Rong, Sun, Peiqing

“…Cancer stem cells (CSCs) are a small population of stem cell-like cancer cells that can initiate tumors in vivo, and are the major source of cancer initiation,…”
Get full text

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1 by Wu, Xiao-Nan, Wu, Su-Qin, Han, Jiahuai, Zhang, Hongbing, Wang, Yan-Hai, Lu, Bao-Ju, Dong, Meng-Qiu, Sun, Peiqing, Lin, Sheng-Cai, Guan, Kun-Liang, Zheng, Min

“…Cell growth can be suppressed by stressful environments, but the role of stress pathways in this process is largely unknown. Here we show that a cascade of…”
Get full text