Search Results - "PEINADO, Héctor"

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts by Peinado, Héctor, Lavotshkin, Simon, Lyden, David

“…Abstract Metastasis is a multistep process that requires acquisition of malignant cell phenotypes which allow tumor cells to escape from the primary tumor…”
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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis by Becker, Annette, Thakur, Basant Kumar, Weiss, Joshua Mitchell, Kim, Han Sang, Peinado, Héctor, Lyden, David

“…Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant…”
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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? by Cano, Amparo, Peinado, Héctor, Olmeda, David

“…The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these…”
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ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells by Fuentes, Pedro, Sesé, Marta, Guijarro, Pedro J., Emperador, Marta, Sánchez-Redondo, Sara, Peinado, Héctor, Hümmer, Stefan, Ramón y Cajal, Santiago

“…Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% of cancer-related deaths. The integrin ITGB3 has been previously…”
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Pre-metastatic niches: organ-specific homes for metastases by Peinado, Héctor, Zhang, Haiying, Matei, Irina R., Costa-Silva, Bruno, Hoshino, Ayuko, Rodrigues, Goncalo, Psaila, Bethan, Kaplan, Rosandra N., Bromberg, Jacqueline F., Kang, Yibin, Bissell, Mina J., Cox, Thomas R., Giaccia, Amato J., Erler, Janine T., Hiratsuka, Sachie, Ghajar, Cyrus M., Lyden, David

“…Key Points Organs of future metastasis are selectively and actively modified by the primary tumour before metastatic spread has occurred. Tumours induce the…”
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Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation by Zhang, Haiying, Freitas, Daniela, Kim, Han Sang, Fabijanic, Kristina, Li, Zhong, Chen, Haiyan, Mark, Milica Tesic, Molina, Henrik, Martin, Alberto Benito, Bojmar, Linda, Fang, Justin, Rampersaud, Sham, Hoshino, Ayuko, Matei, Irina, Kenific, Candia M., Nakajima, Miho, Mutvei, Anders Peter, Sansone, Pasquale, Buehring, Weston, Wang, Huajuan, Jimenez, Juan Pablo, Cohen-Gould, Leona, Paknejad, Navid, Brendel, Matthew, Manova-Todorova, Katia, Magalhães, Ana, Ferreira, José Alexandre, Osório, Hugo, Silva, André M., Massey, Ashish, Cubillos-Ruiz, Juan R., Galletti, Giuseppe, Giannakakou, Paraskevi, Cuervo, Ana Maria, Blenis, John, Schwartz, Robert, Brady, Mary Sue, Peinado, Héctor, Bromberg, Jacqueline, Matsui, Hiroshi, Reis, Celso A., Lyden, David

“…The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By…”
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FunRich proteomics software analysis, let the fun begin by Benito-Martin, Alberto, Peinado, Héctor

“…Protein MS analysis is the preferred method for unbiased protein identification. It is normally applied to a large number of both small‐scale and…”
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Mechanisms of lymph node metastasis: An extracellular vesicle perspective by García-Silva, Susana, Peinado, Héctor

“…In several solid tumors such as breast cancer, prostate cancer, colorectal cancer or melanoma, tumor draining lymph nodes are the earliest tissues where…”
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The influence of tumour-derived extracellular vesicles on local and distal metastatic dissemination by Nogués, Laura, Benito-Martin, Alberto, Hergueta-Redondo, Marta, Peinado, Héctor

“…Extracellular vesicles (EVs) are key mediators of intercellular communication that have been ignored for decades. Tumour cells benefit from the secretion of…”
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET by Peinado, Héctor, Alečković, Maša, Lavotshkin, Simon, Matei, Irina, Costa-Silva, Bruno, Moreno-Bueno, Gema, Hergueta-Redondo, Marta, Williams, Caitlin, García-Santos, Guillermo, Ghajar, Cyrus M, Nitadori-Hoshino, Ayuko, Hoffman, Caitlin, Badal, Karen, Garcia, Benjamin A, Callahan, Margaret K, Yuan, Jianda, Martins, Vilma R, Skog, Johan, Kaplan, Rosandra N, Brady, Mary S, Wolchok, Jedd D, Chapman, Paul B, Kang, Yibin, Bromberg, Jacqueline, Lyden, David

“…Exosomes can transfer proteins and nucleic acids from one cell to another, altering the phenotype of the recipient cell. In the case of cancer, tumor-derived…”
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Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo by Hyenne, Vincent, Ghoroghi, Shima, Collot, Mayeul, Bons, Joanna, Follain, Gautier, Harlepp, Sébastien, Mary, Benjamin, Bauer, Jack, Mercier, Luc, Busnelli, Ignacio, Lefebvre, Olivier, Fekonja, Nina, Garcia-Leon, Maria J., Machado, Pedro, Delalande, François, López, Ana Amor, Silva, Susana Garcia, Verweij, Frederik J., van Niel, Guillaume, Djouad, Farida, Peinado, Héctor, Carapito, Christine, Klymchenko, Andrey S., Goetz, Jacky G.

“…Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs…”
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Phagocytosis imprints heterogeneity in tissue-resident macrophages by A-Gonzalez, Noelia, Quintana, Juan A, García-Silva, Susana, Mazariegos, Marina, González de la Aleja, Arturo, Nicolás-Ávila, José A, Walter, Wencke, Adrover, Jose M, Crainiciuc, Georgiana, Kuchroo, Vijay K, Rothlin, Carla V, Peinado, Héctor, Castrillo, Antonio, Ricote, Mercedes, Hidalgo, Andrés

“…Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions,…”
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Macromolecular Crowding Meets Tissue Engineering by Self-Assembly: A Paradigm Shift in Regenerative Medicine by Satyam, Abhigyan, Kumar, Pramod, Fan, Xingliang, Gorelov, Alexander, Rochev, Yury, Joshi, Lokesh, Peinado, Héctor, Lyden, David, Thomas, Benjamin, Rodriguez, Brian, Raghunath, Michael, Pandit, Abhay, Zeugolis, Dimitrios

“…MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in…”
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Melanosomes foster a tumour niche by activating CAFs by García-Silva, Susana, Peinado, Héctor

“…Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches. Pigmented melanosomes are now shown to have a…”
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Gasdermin-B promotes invasion and metastasis in breast cancer cells by Hergueta-Redondo, Marta, Sarrió, David, Molina-Crespo, Ángela, Megias, Diego, Mota, Alba, Rojo-Sebastian, Alejandro, García-Sanz, Pablo, Morales, Saleta, Abril, Sandra, Cano, Amparo, Peinado, Héctor, Moreno-Bueno, Gema

“…Gasdermin B (GSDMB) belongs to the Gasdermin protein family that comprises four members (GSDMA-D). Gasdermin B expression has been detected in some tumor types…”
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The need for new treatments targeting MPNST: the potential of strategies combining MEK inhibitors with antiangiogenic agents by Gonzalez-Muñoz, Teresa, Kim, AeRang, Ratner, Nancy, Peinado, Héctor

“…Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive soft tissue sarcomas that represent an important clinical challenge, particularly given their…”
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Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis by Rodrigues, Gonçalo, Hoshino, Ayuko, Kenific, Candia M., Matei, Irina R., Steiner, Loïc, Freitas, Daniela, Kim, Han Sang, Oxley, Peter R., Scandariato, Ilana, Casanova-Salas, Irene, Dai, Jinxiang, Badwe, Chaitanya R., Gril, Brunilde, Tešić Mark, Milica, Dill, Brian D., Molina, Henrik, Zhang, Haiying, Benito-Martin, Alberto, Bojmar, Linda, Ararso, Yonathan, Offer, Katharine, LaPlant, Quincey, Buehring, Weston, Wang, Huajuan, Jiang, Xinran, Lu, Tyler M., Liu, Yuan, Sabari, Joshua K., Shin, Sandra J., Narula, Navneet, Ginter, Paula S., Rajasekhar, Vinagolu K., Healey, John H., Meylan, Etienne, Costa-Silva, Bruno, Wang, Shizhen Emily, Rafii, Shahin, Altorki, Nasser Khaled, Rudin, Charles M., Jones, David R., Steeg, Patricia S., Peinado, Héctor, Ghajar, Cyrus M., Bromberg, Jacqueline, de Sousa, Maria, Pisapia, David, Lyden, David

“…The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving…”
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Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas by Peinado, Héctor, Moreno-Bueno, Gema, Hardisson, David, Pérez-Gómez, Eduardo, Santos, Vanesa, Mendiola, Marta, de Diego, Juan Ignacio, Nistal, Manuel, Quintanilla, Miguel, Portillo, Francisco, Cano, Amparo

“…Lysyl oxidase-like 2 (Loxl2) interacts with and stabilizes Snai1 transcription factor, promoting epithelial-mesenchymal transition. Either Loxl2 or Snai1…”
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Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles by Olmeda, David, Cerezo-Wallis, Daniela, Castellano-Sanz, Elena, García-Silva, Susana, Peinado, Héctor, Soengas, María S.

“…[Display omitted] Imaging of the lymphatic vasculature has gained great attention in various fields, not only because lymphatic vessels act as a key draining…”
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DNA-Loaded Extracellular Vesicles in Liquid Biopsy: Tiny Players With Big Potential? by García-Silva, Susana, Gallardo, Miguel, Peinado, Héctor

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