Search Results - "PEDATA, Felicita"

Adenosine in the central nervous system: release mechanisms and extracellular concentrations by Latini, Serena, Pedata, Felicita

“…Adenosine has several functions within the CNS that involve an inhibitory tone of neurotransmission and neuroprotective actions in pathological conditions. The…”
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A2B Adenosine Receptors: When Outsiders May Become an Attractive Target to Treat Brain Ischemia or Demyelination by Coppi, Elisabetta, Dettori, Ilaria, Cherchi, Federica, Bulli, Irene, Venturini, Martina, Lana, Daniele, Giovannini, Maria Grazia, Pedata, Felicita, Pugliese, Anna Maria

“…Adenosine is a signaling molecule, which, by activating its receptors, acts as an important player after cerebral ischemia. Here, we review data in the…”
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Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype by Coppi, Elisabetta, Cherchi, Federica, Lucarini, Elena, Ghelardini, Carla, Pedata, Felicita, Jacobson, Kenneth A., Di Cesare Mannelli, Lorenzo, Pugliese, Anna Maria, Salvemini, Daniela

“…Agonists of the Gi protein-coupled A3 adenosine receptor (A3AR) have shown important pain-relieving properties in preclinical settings of several pain models…”
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Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia by Melani, Alessia, Corti, Francesca, Cellai, Lucrezia, Giuliana Vannucchi, Maria, Pedata, Felicita

“…Abstract Evidence indicate that adenosine A2A receptor subtype is of critical importance in stroke. An overexpression of A2A adenosine receptors occurs at…”
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Therapeutic Potential of Highly Selective A3 Adenosine Receptor Ligands in the Central and Peripheral Nervous System by Coppi, Elisabetta, Cherchi, Federica, Venturini, Martina, Lucarini, Elena, Corradetti, Renato, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Pedata, Felicita, Pugliese, Anna

“…Ligands of the Gi protein-coupled adenosine A3 receptor (A3R) are receiving increasing interest as attractive therapeutic tools for the treatment of a number…”
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Protective Effect of Adenosine A2B Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat by Dettori, Ilaria, Gaviano, Lisa, Ugolini, Filippo, Lana, Daniele, Bulli, Irene, Magni, Giada, Rossi, Francesca, Giovannini, Maria Grazia, Pedata, Felicita

“…Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to excitotoxicity, followed by a secondary brain injury that…”
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Role of Carbonic Anhydrase in Cerebral Ischemia and Carbonic Anhydrase Inhibitors as Putative Protective Agents by Bulli, Irene, Dettori, Ilaria, Coppi, Elisabetta, Cherchi, Federica, Venturini, Martina, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Nocentini, Alessio, Supuran, Claudiu T, Pugliese, Anna Maria, Pedata, Felicita

“…Ischemic stroke is a leading cause of death and disability worldwide. The only pharmacological treatment available to date for cerebral ischemia is tissue…”
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Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation by Chen, Jiang-Fan, Sonsalla, Patricia K, Pedata, Felicita, Melani, Alessia, Domenici, Maria Rosaria, Popoli, Patrizia, Geiger, Jonathan, Lopes, Luísa V, de Mendonça, Alexandre

“…This review summarizes recent developments that have contributed to understand how adenosine receptors, particularly A2A receptors, modulate brain injury in…”
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New Insight into the Role of Adenosine in Demyelination, Stroke and Neuropathic Pain by Coppi, Elisabetta, Dettori, Ilaria, Cherchi, Federica, Bulli, Irene, Venturini, Martina, Pedata, Felicita, Pugliese, Anna Maria

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Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum by Melani, Alessia, Corti, Francesca, Stephan, Holger, Müller, Christa E., Donati, Chiara, Bruni, Paola, Vannucchi, Maria Giuliana, Pedata, Felicita

“…In the central nervous system (CNS) ATP and adenosine act as transmitters and neuromodulators on their own receptors but it is still unknown which part of…”
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Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors by Chen, Jiang-Fan, Pedata, Felicita

“…Over the past 5 years, the adenosine A(2A) receptor (A(2A)R) is emerging as an attractive therapeutic target for modulating brain injury in a variety of animal…”
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The Selective Antagonism of Adenosine A2B Receptors Reduces the Synaptic Failure and Neuronal Death Induced by Oxygen and Glucose Deprivation in Rat CA1 Hippocampus in Vitro by Fusco, Irene, Ugolini, Filippo, Lana, Daniele, Coppi, Elisabetta, Dettori, Ilaria, Gaviano, Lisa, Nosi, Daniele, Cherchi, Federica, Pedata, Felicita, Giovannini, Maria G., Pugliese, Anna M.

“…Ischemia is a multifactorial pathology characterized by different events evolving in time. Immediately after the ischemic insult, primary brain damage is due…”
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A2B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis by Coppi, Elisabetta, Cencetti, Francesca, Cherchi, Federica, Venturini, Martina, Donati, Chiara, Bruni, Paola, Pedata, Felicita, Pugliese, Anna Maria

“…Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain. Impairments in the process of myelination, or demyelinating insults, might…”
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Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models by Dettori, Ilaria, Fusco, Irene, Bulli, Irene, Gaviano, Lisa, Coppi, Elisabetta, Cherchi, Federica, Venturini, Martina, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Nocentini, Alessio, Supuran, Claudiu T., Pugliese, Anna Maria, Pedata, Felicita

“…Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic…”
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Adenosine A_(2A) Receptors Modulate Acute Injury and Neuroinflammation in Brain Ischemia by Pedata, Felicita, Pugliese, Anna Maria, Coppi, Elisabetta, Dettori, Ilaria, Maraula, Giovanna, Cellai, Lucrezia, Melani, Alessia

“…The extracellular concentration of adenosine in the brain increases dramatically during ischemia. Adenosine [A.sub.2A] receptor is expressed in neurons and…”
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UDP-glucose enhances outward K+ currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors by Coppi, Elisabetta, Maraula, Giovanna, Fumagalli, Marta, Failli, Paola, Cellai, Lucrezia, Bonfanti, Elisabetta, Mazzoni, Luca, Coppini, Raffaele, Abbracchio, Maria P., Pedata, Felicita, Pugliese, Anna Maria

“…In the developing and mature central nervous system, NG2 expressing cells comprise a population of cycling oligodendrocyte progenitor cells (OPCs) that…”
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A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Is Protective in a Rat Model of Transient Cerebral Ischemia by Dettori, Ilaria, Gaviano, Lisa, Melani, Alessia, Lucarini, Laura, Durante, Mariaconcetta, Masini, Emanuela, Pedata, Felicita

“…Cerebral ischemia is a multifactorial pathology characterized by different events evolving in time. The acute injury, characterized by excitoxicity, is…”
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Equilibrative Nucleoside Transporter ENT1 as a Biomarker of Huntington Disease by Guitart, Xavier, Bonaventura, Jordi, Rea, William, Orrú, Marco, Cellai, Lucrezia, Dettori, Ilaria, Pedata, Felicita, Brugarolas, Marc, Cortés, Antonio, Casadó, Vicent, Chang, Ching-Pang, Narayanan, Manikandan, Chern, Yijuang, Ferré, Sergi

“…Abstract The initial goal of this study was to investigate alterations in adenosine A2A receptor (A2A R) density or function in a rat model of Huntington…”
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CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation by Impellizzeri, Daniela, Di Paola, Rosanna, Esposito, Emanuela, Mazzon, Emanuela, Paterniti, Irene, Melani, Alessia, Bramanti, Placido, Pedata, Felicita, Cuzzocrea, Salvatore

“…Adenosine A2A receptor agonists may be important regulators of inflammation. The aim of this study was to investigate the effects of CGS 21680 (0.1mg/kgi.p.),…”
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Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus by Venturini, Martina, Cherchi, Federica, Santalmasi, Clara, Frulloni, Lucia, Dettori, Ilaria, Catarzi, Daniela, Pedata, Felicita, Colotta, Vittoria, Varano, Flavia, Coppi, Elisabetta, Pugliese, Anna Maria

“…In recent years, the use of multi-target compounds has become an increasingly pursued strategy to treat complex pathologies, including cerebral ischemia…”
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