Search Results - "PECHHOLD, K"

IGRP and insulin vaccination induce CD8+ T cell‐mediated autoimmune diabetes in the RIP‐CD80GP mouse by Fuchs, Y. F., Adler, K., Lindner, A., Karasinsky, A., Wilhelm, C., Weigelt, M., Balke, H., Förtsch, K., Mortler‐Hildebrandt, L. F., Harlan, D. M., Pechhold, K., Ziegler, A.‐G., Bonifacio, E.

“…Summary Autoimmune diabetes is characterized by autoantigen‐specific T cell‐mediated destruction of pancreatic islet beta cells, and CD8+ T cells are key…”
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Low Dose Streptozotocin-Induced Diabetes in Rat Insulin Promoter-mCD80-Transgenic Mice Is T Cell Autoantigen-Specific and CD28 Dependent by Pechhold, Klaus, Patterson, Noelle B, Blum, Carmen, Fleischacker, Christine L, Boehm, Bernhard O, Harlan, David M

“…Although transgenic mice expressing murine B7-1 (mCD80) on their pancreatic beta cells under the rat insulin-1 promoter (RIP-mCD80(+) mice) rarely develop…”
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Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice by Harlan, D. M., Barnett, M. A., Abe, R., Pechhold, K., Patterson, N. B., Gray, G. S., June, C. H.

“…Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice. D M Harlan , M A Barnett , R Abe , K Pechhold , N B Patterson , G S…”
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T cell apoptosis triggered via the CD3/T cell receptor complex and alternative activation pathways by Kabelitz, D, Pohl, T, Pechhold, K

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mRNA analysis of intracytoplasmically-stained, FACS-purified pancreatic islet cells using the quantitative nuclease protection assay by Pechhold, S, Stouffer, M, Walker, G, Martel, R, Seligmann, B, Hang, Y, Stein, R, Harlan, DM, Pechhold, K

“…Exploring the pathophysiology underlying diabetes mellitus requires characterizing the cellular constituents of pancreatic islets, primarily insulin-producing…”
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Apoptosis of mature T lymphocytes: putative role in the regulation of cellular immune responses and in the pathogenesis of HIV infection by Kabelitz, D, Pohl, T, Oberg, H H, Pechhold, K, Dobmeyer, T, Rossol, R

“…In this chapter, some aspects of programmed cell death, or apoptosis, of T lymphocytes are discussed. It has been recognized that transformed T cells and…”
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Leukaemic T cells from patients with chronic lymphocytic leukaemia of T-cell origin respond to Staphylococcus aureus enterotoxin superantigens by Metzger, R, Melmer, G, Schondelmaier, S, Heckl-Ostreicher, B, Nerl, C, Pechhold, K, Epplen, J T, Kabelitz, D

“…We investigated the in vitro responsiveness of peripheral blood lymphocytes from two patients with T-cell chronic lymphocytic leukaemia (T-CLL) to…”
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Primary activation of V gamma 9-expressing gamma delta T cells by Mycobacterium tuberculosis. Requirement for Th1-type CD4 T cell help and inhibition by IL-10 by Pechhold, K, Wesch, D, Schondelmaier, S, Kabelitz, D

“…Purified peripheral blood gamma delta T cells proliferated vigorously in response to killed Mycobacterium tuberculosis (M. tb.) in the presence of PBMC but not…”
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The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells by Kabelitz, D, Bender, A, Prospero, T, Wesselborg, S, Janssen, O, Pechhold, K

“…We have previously reported that peripheral blood gamma/delta + T cells proliferate in high frequency (1 in 2-20) in response to heat-killed Mycobacterium…”
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Perspectives in transplantation immunology 1991 by Kabelitz, D, da Silva Lobo, M L, Pechhold, K

“…The clinical success of organ transplantation depends to a large degree on the immunological acceptance of the grafted organ. This paper summarizes from an…”
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Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice by KARGES, Wolfram, PECHHOLD, Klaus, AL DAHOUK, Sascha, RIEGGER, Ines, RIEF, Matthias, WISSMANN, Andrea, SCHIRMBECK, Reinhold, BARTH, Christoph, BOEHM, Bernhard O

“…Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice Wolfram Karges 1 , Klaus Pechhold 3…”
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T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells by Janssen, O, Wesselborg, S, Heckl-Ostreicher, B, Pechhold, K, Bender, A, Schondelmaier, S, Moldenhauer, G, Kabelitz, D

“…mAb directed against the TCR/CD3 complex activate resting T cells. However, TCR/CD3 signaling induces death by apoptosis in immature (CD4+CD8+) murine…”
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Mycobacteria-reactive gamma delta T cells in HIV-infected individuals: lack of V gamma 9 cell responsiveness is due to deficiency of antigen-specific CD4 T helper type 1 cells by Wesch, D, Kabelitz, D, Friese, K, Pechhold, K

“…Human gamma delta T lymphocytes expressing the variable T cell receptor elements V gamma 9 paired with V delta 2 are activated by antigen derived from…”
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The primary response of human γ/δ+ T cells to Mycobacterium tuberculosis is restricted to Vγ9-bearing cells by KABELITZ, D, BENDER, A, PROSPERO, T, WESSELBORG, S, JANSSEN, O, PECHHOLD, K

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Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated diabetes by Pechhold, Klaus, Karges, Wolfram, Blum, Carmen, Boehm, Bernhard O., Harlan, David M.

“…T cell responses toward pancreatic beta cell autoantigens arise spontaneously or on immunization in many mouse strains, yet sustained islet infiltration and…”
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Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts by Pechhold, K, Patterson, NB, Craighead, N, Lee, KP, June, CH, Harlan, DM

“…Optimal T cell activation requires signals delivered via both the TCR and the costimulatory receptors. Considerable experimental data now suggest that this…”
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T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor γδ+ T cells by JANSSEN, O, WESSELBORG, S, HECKL-ÖSTREICHER, B, PECHHOLD, K, BENDER, A, SCHONDELMAIER, S, MOLDENHAUER, G, KABELITZ, D

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Activation and activation-driven death of human gamma/delta T cells by Kabelitz, D, Pechhold, K, Bender, A, Wesselborg, S, Wesch, D, Friese, K, Janssen, O

“…We have concentrated on three functional aspects of human gamma/delta+ T cells. (1) Peripheral blood gamma/delta+ T cells proliferate at a high frequency in…”
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Human peripheral blood gamma delta T cells are uniformly sensitive to destruction by the lysosomotropic agents leucine methyl ester and leucyl leucine methyl ester by Pechhold, K, Kabelitz, D

“…Treatment of peripheral blood mononuclear cells (PBMC) with the lysosomotropic agent leucine methyl ester (Leu-OMe) eliminates monocytes/macrophages and…”
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Antigen-induced death of mature T lymphocytes: analysis by flow cytometry by Kabelitz, D, Oberg, H H, Pohl, T, Pechhold, K

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