Search Results - "PECHAN, Peter A"

Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo by JACOBS, Andreas, TJUVAJEV, Juri G, PECHAN, Peter A, CHIOCCA, E. Antonio, BREAKEFIELD, Xandra O, BLASBERG, Ronald G, DUBROVIN, Michael, AKHURST, Timothy, BALATONI, Julius, BEATTI, Bradley, JOSHI, Revathi, FINN, Ronald, LARSON, Steven M, HERRLINGER, Ulrich

“…To evaluate the efficiency of gene delivery in gene therapy strategies for malignant brain tumors, it is important to determine the distribution and magnitude…”
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Free radicals induce gene expression of NGF and bFGF in rat astrocyte culture by Pechan, P A, Chowdhury, K, Seifert, W

“…Hydrogen peroxide (H2O2) is a type of active oxygen species produced mainly in blood by inflammation, ischemia or anoxia. Treatment of rat neonatal cortical…”
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Genetically modified fibroblasts producing NGF protect hippocampal neurons after ischemia in the rat by Pechan, P A, Yoshida, T, Panahian, N, Moskowitz, M A, Breakefield, X O

“…The neuroprotective effect of nerve growth factor (NGF) on the pyramidal cells in the vulnerable CA1-CA2 sectors of the hippocampus was investigated in a rat…”
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HSV-1 infected cell proteins influence tetracycline-regulated transgene expression by Herrlinger, Ulrich, Pechan, Peter A., Jacobs, Andreas H., Woiciechowski, Christian, Rainov, Nikolai G., Fraefel, Cornel, Paulus, Werner, Reeves, Steven A.

“…Background This study investigates elements of herpes simplex virus type 1 (HSV‐1) which influence transgene expression in tetracycline‐regulated expression…”
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Combined HSV-1 recombinant and amplicon piggyback vectors: replication-competent and defective forms, and therapeutic efficacy for experimental gliomas by Pechan, Peter A., Herrlinger, Ulrich, Aghi, Manish, Jacobs, Andreas, Breakefield, Xandra O.

“…Background The versatility of HSV‐1 vectors includes large transgene capacity, selective replication of mutants in dividing cells, and availability of…”
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bFGF induces its own gene expression in astrocytic and hippocampal cell cultures by Flott-Rahmel, B, Gerdes, W, Pechan, P A, Brysch, W, Schlingensiepen, K H, Seifert, W

“…Basic FGF mRNA induction by bFGF was investigated in cell cultures from rat brain, i.e. postnatal day 2 cortex and embryonic day 18 hippocampus. In situ…”
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HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells by Johnston, K M, Jacoby, D, Pechan, P A, Fraefel, C, Borghesani, P, Schuback, D, Dunn, R J, Smith, F I, Breakefield, X O

“…Novel hybrid vectors, which incorporate critical elements of both herpes simplex virus type 1 (HSV-1) amplicon vectors and adeno-associated virus (AAV)…”
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Gene therapy for brain tumors by Kramm, C M, Sena-Esteves, M, Barnett, F H, Rainov, N G, Schuback, D E, Yu, J S, Pechan, P A, Paulus, W, Chiocca, E A, Breakefield, X O

“…Gene therapy has opened new doors for treatment of neoplastic diseases. This new approach seems very attractive, especially for glioblastomas, since treatment…”
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A novel 'piggyback' packaging system for herpes simplex virus amplicon vectors by Pechan, P A, Fotaki, M, Thompson, R L, Dunn, R, Chase, M, Chiocca, E A, Breakefield, X O

“…Recombinant and amplicon vectors derived from herpes simplex virus type 1 (HSV-1) have proven to be an efficient means of gene delivery to cells in culture and…”
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Human fetal astrocytes as an ex vivo gene therapy vehicle for delivering biologically active nerve growth factor by Lin, Q, Cunningham, L A, Epstein, L G, Pechan, P A, Short, M P, Fleet, C, Bohn, M C

“…The therapeutic use of neurotrophic factors for neurodegenerative diseases is promising, however, optimal methods for continuous delivery of these substances…”
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Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors by Kramm, C M, Rainov, N G, Sena-Esteves, M, Chase, M, Pechan, P A, Chiocca, E A, Breakefield, X O

“…The present study investigated the ability of a recombinant herpes simplex virus type 1 (HSV) vector to deliver genes into disseminated brain tumor foci…”
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Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment by Kramm, C M, Rainov, N G, Sena-Esteves, M, Barnett, F H, Chase, M, Herrlinger, U, Pechan, P A, Chiocca, E A, Breakefield, X O

“…Brain tumors that have disseminated into cerebrospinal fluid (CSF) pathways are an unresolved therapeutic problem, especially in pediatric neurooncology. Here…”
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Glutamate induces the growth factors NGF, bFGF, the receptor FGF-R1 and c-fos mRNA expression in rat astrocyte culture by Pechán, P A, Chowdhury, K, Gerdes, W, Seifert, W

“…The effect of glutamate on primary cultures of rat cortical astrocytes was studied using Northern blot hybridization. Incubation with glutamate (100 microM, 15…”
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Syngeneic spleen cell immunization induces high mortality among progeny in mice by Pechan, P A

“…Syngeneic spleen cell immunization of C57BL/6J females prior to syngeneic matings resulted in significant perinatal and postnatal mortality and increased…”
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