Search Results - "PEARSON, T. C"

Renal Transplantation Using Belatacept Without Maintenance Steroids or Calcineurin Inhibitors by Kirk, A. D., Guasch, A., Xu, H., Cheeseman, J., Mead, S. I., Ghali, A., Mehta, A. K., Wu, D., Gebel, H., Bray, R., Horan, J., Kean, L. S., Larsen, C. P., Pearson, T. C.

“…Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative, but existing…”
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Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long‐Term Renal Allograft Function by Adams, A. B., Goldstein, J., Garrett, C., Zhang, R., Patzer, R. E., Newell, K. A., Turgeon, N. A., Chami, A. S., Guasch, A., Kirk, A. D., Pastan, S. O., Pearson, T. C., Larsen, C. P.

“…Belatacept, a T cell costimulation blocker, demonstrated superior renal function, lower cardiovascular risk, and improved graft and patient survival in renal…”
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Detection of contaminated hazelnuts and ground red chili pepper flakes by multispectral imaging by Kalkan, H., Beriat, P., Yardimci, Y., Pearson, T.C.

“…► Aflatoxin contaminated food items can be detected by multispectral imaging. ► Aflatoxin level of the food lot can be decreased by elimination of the detected…”
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Donor‐Directed MHC Class I Antibody Is Preferentially Cleared from Sensitized Recipients of Combined Liver/Kidney Transplants by Dar, W., Agarwal, A., Watkins, C., Gebel, H. M., Bray, R. A., Kokko, K. E., Pearson, T. C., Knechtle, S. J.

“…For patients with chronic renal and liver diseases, simultaneous liver and kidney transplantation (SLKT) is the best therapeutic option. The role of a…”
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Experience with a Novel Efalizumab‐Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation by Turgeon, N. A., Avila, J. G., Cano, J. A., Hutchinson, J. J., Badell, I. R., Page, A. J., Adams, A. B., Sears, M. H., Bowen, P. H., Kirk, A. D., Pearson, T. C., Larsen, C. P.

“…Islet transplantation is an experimental therapy for selected patients with type 1 diabetes (T1DM). It remains limited by immunosuppressive drug toxicity,…”
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Transplant Tolerance in Non‐Human Primates: Progress, Current Challenges and Unmet Needs by Kean, L. S., Gangappa, S., Pearson, T. C., Larsen, C. P.

“…Given the significant morbidity associated with current post‐transplant immunosuppressive regimens, induction of immune tolerance continues to be an important…”
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Engraftment of Adult Porcine Islet Xenografts in Diabetic Nonhuman Primates Through Targeting of Costimulation Pathways by Cardona, K., Milas, Z., Strobert, E., Cano, J., Jiang, W., Safley, S. A., Gangappa, S., Hering, B. J., Weber, C. J., Pearson, T. C., Larsen, C. P.

“…Recent advances in human allogeneic islet transplantation have established β‐cell replacement therapy as a potentially viable treatment option for individuals…”
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Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis by MCMULLIN, Mary F, BAREFORD, D, RYAN, Kate, PEARSON, T. C, WILKINS, Bridget, CAMPBELL, P, GREEN, A. R, HARRISON, Claire, HUNT, Beverley, OSCIER, D, POLKEY, M. I, REILLY, J. T, ROSENTHAL, E

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Reduction of aflatoxin and fumonisin contamination in yellow corn by high-speed dual-wavelength sorting by Pearson, T.C, Wicklow, D.T, Pasikatan, M.C

“…A high-speed dual-wavelength sorter was tested for removing corn contaminated in the field with aflatoxin and fumonisin. To achieve accurate sorting, single…”
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NK Cells Mediate Costimulation Blockade‐Resistant Rejection of Allogeneic Stem Cells During Nonmyeloablative Transplantation by Kean, L. S., Hamby, K., Koehn, B., Lee, E., Coley, S., Stempora, L., Adams, A. B., Heiss, E., Pearson, T. C., Larsen, C. P.

“…Although T‐cell CD28/CD40 costimulation blockade represents a powerful mechanism to promote immune tolerance during murine allotransplantation, it has not yet…”
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Induction of Chimerism in Rhesus Macaques through Stem Cell Transplant and Costimulation Blockade‐Based Immunosuppression by Kean, L. S., Adams, A. B., Strobert, E., Hendrix, R., Gangappa, S., Jones, T. R., Shirasugi, N., Rigby, M. R., Hamby, K., Jiang, J., Bello, H., Anderson, D., Cardona, K., Durham, M. M., Pearson, T. C., Larsen, C. P.

“…A strategy for producing high‐level hematopoietic chimerism after non‐myeloablative conditioning has been established in the rhesus macaque. This strategy…”
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CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40‐Specific Antibody 3A8 by Badell, I. R., Russell, M. C., Cardona, K., Shaffer, V. O., Turner, A. P., Avila, J. G., Cano, J. A., Leopardi, F. V., Song, M., Strobert, E. A., Ford, M. L., Pearson, T. C., Kirk, A. D., Larsen, C. P.

“…Islet transplantation to treat type 1 diabetes has been limited in part by toxicities of current immunosuppression and recipient humoral sensitization…”
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NK Cells Rapidly Reject Allogeneic Bone Marrow in the Spleen Through a Perforin‐ and Ly49D‐Dependent, but NKG2D‐Independent Mechanism by Hamby, K., Trexler, A., Pearson, T. C., Larsen, C. P., Rigby, M. R., Kean, L. S.

“…We have used a sensitive and specific in vivo killing assay to monitor the kinetics, anatomic location and mechanisms controlling NK‐mediated rejection of…”
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Organ Donation and Utilization, 1995–2004: Entering the Collaborative Era by Marks, W. H., Wagner, D., Pearson, T. C., Orlowski, J. P., Nelson, P. W., McGowan, J. J., Guidinger, M. K., Burdick, J.

“…Continued progress in organ donation will help enable transplantation to alleviate the increasing incidence of end‐stage organ disease. This article discusses…”
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Hyperhemolytic transfusion reaction in sickle cell disease by Win, Nay, Doughty, Heidi, Telfer, Paul, Wild, Barbara J., Pearson, T.C.

“…BACKGROUND: An atypical form of life‐threatening hemolytic transfusion reaction (HTR) in patients with sickle cell disease (SCD) has been well described in the…”
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A Mouse Model for Polyomavirus‐Associated Nephropathy of Kidney Transplants by Han Lee, E. D., Kemball, C. C., Wang, J., Dong, Y., Stapler, D. C., Hamby, K. M., Gangappa, S., Newell, K. A., Pearson, T. C., Lukacher, A. E., Larsen, C. P.

“…Polyomavirus‐associated nephropathy is an important cause of dysfunction and failure of renal transplants. BK virus is an ubiquitous human polyoma virus that…”
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Interpretation of measured red cell mass and plasma volume in adults: Expert Panel on Radionuclides of the International Council for Standardization in Haematology by Pearson, T C, Guthrie, D L, Simpson, J, Chinn, S, Barosi, G, Ferrant, A, Lewis, S M, Najean, Y

“…Four European centres provided height and weight data on 202 males and 204 females undergoing red cell mass (RCM) and plasma volume (PV) measurements. For…”
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Role of CD28-B7 Interactions in Generation and Maintenance of CD8 T Cell Memory by Suresh, M, Whitmire, Jason K, Harrington, Laurie E, Larsen, Christian P, Pearson, Thomas C, Altman, John D, Ahmed, Rafi

“…Although the role of CD28-B7 interaction in the activation of naive T cells is well established, its importance in the generation and maintenance of T cell…”
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Regulation of immunostimulatory function and costimulatory molecule (B7- 1 and B7-2) expression on murine dendritic cells by Larsen, CP, Ritchie, SC, Hendrix, R, Linsley, PS, Hathcock, KS, Hodes, RJ, Lowry, RP, Pearson, TC

“…Dendritic cells (DC) play a critical role in the initiation of T cell-mediated immune responses, and express costimulatory molecules that are required for…”
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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways by Larsen, Christian P, Elwood, Eric T, Alexander, Diane Z, Ritchie, Shannon C, Hendrix, Rose, Tucker-Burden, Carol, Cho, Hong Rae, Aruffo, Alejandro, Hollenbaugh, Diane, Linsley, Peter S, Winn, Kevin J, Pearson, Thomas C

“…The receptor-ligand pairs CD28-B7 and CD40-gp39 are essential for the initiation and amplification of T-cell-dependent immune responses. CD28-B7 interactions…”
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