Search Results - "PEARSON, P. G"

Copy number variations in three children with sudden infant death by Toruner, GA, Kurvathi, R, Sugalski, R, Shulman, L, Twersky, S, Pearson, PG, Tozzi, R, Schwalb, MN, Wallerstein, R

“…Sudden death of an infant is a devastating event that needs an explanation. When an explanation cannot be found, the case is labeled as sudden infant death…”
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Towards improved policy processes for promoting innovation in renewable electricity technologies in the UK by Foxon, T.J., Pearson, P.J.G.

“…This paper analyses recent, current and potential future relations between policy processes and substantive outcomes in UK low carbon innovation policy,…”
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2-amino-3-(methylamino)-propanoic acid (BMAA) pharmacokinetics and blood-brain barrier permeability in the rat by Duncan, M W, Villacreses, N E, Pearson, P G, Wyatt, L, Rapoport, S I, Kopin, I J, Markey, S P, Smith, Q R

“…2-Amino-3-(methylamino)-propanoic acid (BMAA) is a neurotoxic, excitatory amino acid which has been linked through cycad use and consumption with the onset of…”
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Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission by Kassahun, Kelem, Pearson, Paul G, Tang, Wei, McIntosh, Ian, Leung, Kwan, Elmore, Charles, Dean, Dennis, Wang, Regina, Doss, George, Baillie, Thomas A

“…Therapy with the oral antidiabetic agent troglitazone (Rezulin) has been associated with cases of severe hepatotoxicity and drug-induced liver failure, which…”
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Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes by Wienkers, L C, Steenwyk, R C, Sanders, P E, Pearson, P G

“…Tirilazad mesylate (Freedox), a potent inhibitor of membrane lipid peroxidation in vitro, is under clinical development for the treatment of subarachnoid…”
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Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma by STONE, Julie A, XIN XU, SINGH, Romi, DELUNA, Florencia, DILZER, Stacy C, LASSETER, Kenneth C, WINCHELL, Gregory A, DEUTSCH, Paul J, PEARSON, Paul G, MIGOYA, Elizabeth M, MISTRY, Goutam C, LIWEN XI, MILLER, Alisha, SANDHU, Punam

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities by Slatter, J. Greg, Rashed, Mohamed S, Pearson, Paul G, Han, Deog Hwa, Baillie, Thomas A

“…S-(N-Methylcarbamoyl)-N-acetylcysteine (AMCC), a chemically labile mercapturic acid conjugate, was identified by liquid chromatography-mass spectrometry…”
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Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates by Thomassen, D, Pearson, P G, Slattery, J T, Nelson, S D

“…The hepatotoxic monoterpene pulegone is a major constituent of the herbal abortifacient pennyroyal oil. An approximately equimolar mixture of 2H3- and…”
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Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability by Fleishaker, J C, Pearson, P G, Wienkers, L C, Pearson, L K, Peters, G R

“…The effect of ketoconazole, a CYP3A inhibitor, on the oral bioavailability of tirilazad mesylate was assessed in 12 healthy subjects, who received the…”
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Hormonal Effects on Tirilazad Clearance in Women: Assessment of the Role of CYP3A by Fleishaker, Joseph C., Pearson, Laura K., Pearson, Paul G., Wienkers, Larry C., Hopkins, Nancy K., Peters, Gary R.

“…This study assessed whether the previously reported difference in tirilazad clearance between pre‐ and postmenopausal women is reversed by hormone replacement…”
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In vitro metabolic transformations of 2,4-dipyrrolidinylpyrimidine: a chemical probe for P450-mediated oxidation of tirilazad mesylate by STREEPER, R. T, PEARSON, P. G, ZHAO, Z, MIZSAK, S. A, SANDERS, P. E, WIENKERS, L. C, VRBANAC, J. J

“…1. We have determined that 2,4-dipyrrolidinylpyrimidine (2,4-DPP), used as a model for studies of the metabolism of therapeutic agents containing this moiety,…”
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Replacing 14C with stable isotopes in drug metabolism studies by Abramson, F P, Teffera, Y, Kusmierz, J, Steenwyk, R C, Pearson, P G

“…After administration of a mixed dose of both radioisotope and stable-isotope-labeled tirilazad, we carried out a parallel set of HPLC analyses for drug…”
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EVALUATION OF MICRODOSING STRATEGIES FOR STUDIES IN PRECLINICAL DRUG DEVELOPMENT: DEMONSTRATION OF LINEAR PHARMACOKINETICS IN DOGS OF A NUCLEOSIDE ANALOG OVER A 50-FOLD DOSE RANGE by SANDHU, Punam, VOGEL, John S, BAILLIE, Thomas A, ROSE, Mark J, UBICK, Esther A, BRUNNER, Janice E, WALLACE, Michael A, ADELSBERGER, Jennifer K, BAKER, Maribeth P, HENDERSON, Paul T, PEARSON, Paul G

“…The technique of accelerator mass spectrometry (AMS) was validated successfully and used to study the pharmacokinetics and disposition in dogs of a preclinical…”
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S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate by Pearson, P G, Slatter, J G, Rashed, M S, Han, D H, Grillo, M P, Baillie, T A

“…S-(N-methylcarbamoyl)glutathione, a chemically-reactive glutathione conjugate, has been isolated from the bile of rats administered methyl isocyanate and…”
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Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite by Threadgill, M D, Axworthy, D B, Baillie, T A, Farmer, P B, Farrow, K C, Gescher, A, Kestell, P, Pearson, P G, Shaw, A J

“…S-(N-Methylcarbamoyl)glutathione has been identified by cesium ion liquid secondary ion mass spectrometry as a biliary metabolite in mice of the experimental…”
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Metabolic activation of 1,2-dibromo-3-chloropropane: evidence for the formation of reactive episulfonium ion intermediates by Pearson, Paul G, Soderlund, Erik J, Dybing, Erik, Nelson, Sidney D

“…The nematocide and soil fumigant 1,2-dibromo-3-chloropropane (DBCP) is a carcinogen and a mutagen and displays target-organ toxicity to the testes and the…”
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Disposition of Caspofungin, a Novel Antifungal Agent, in Mice, Rats, Rabbits, and Monkeys by SANDHU, Punam, XIN XU, BONDISKEY, Peter J, BALANI, Suresh K, MORRIS, Michael L, TANG, Yui S, MILLER, Alisha R, PEARSON, Paul G

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Metabolites of Caspofungin Acetate, a Potent Antifungal Agent, in Human Plasma and Urine by Balani, S K, Xu, X, Arison, B H, Silva, M V, Gries, A, DeLuna, F A, Cui, D, Kari, P H, Ly, T, Hop, C E, Singh, R, Wallace, M A, Dean, D C, Lin, J H, Pearson, P G, Baillie, T A

“…Caspofungin acetate (MK-0991) is a semisynthetic pneumocandin derivative being developed as a parenteral antifungal agent with broad-spectrum activity against…”
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Inhibition of in vitro lipid peroxidation by 21-aminosteroids. Evidence for differential mechanisms by Ryan, T P, Steenwyk, R C, Pearson, P G, Petry, T W

“…In a previous report (Ryan and Petry, Arch Biochem Biophys 300: 699-704, 1993), the effects of two 21-aminosteroids (U-74500A and U-74006F) on the oxidation…”
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Enzyme kinetics of cytochrome P450-mediated reactions by Shou, M, Lin, Y, Lu, P, Tang, C, Mei, Q, Cui, D, Tang, W, Ngui, J S, Lin, C C, Singh, R, Wong, B K, Yergey, J A, Lin, J H, Pearson, P G, Baillie, T A, Rodrigues, A D, Rushmore, T H

“…The most common drug-drug interactions may be understood in terms of alterations of metabolism, associated primarily with changes in the activity of cytochrome…”
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