Search Results - "PEARSE, L"

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease by Terzioglu, Gizem, Young-Pearse, Tracy L

“…Abstract Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes…”
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APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly by Preitner, Nicolas, Quan, Jie, Nowakowski, Dan W., Hancock, Melissa L., Shi, Jianhua, Tcherkezian, Joseph, Young-Pearse, Tracy L., Flanagan, John G.

“…Adenomatous polyposis coli (APC) is a microtubule plus-end scaffolding protein important in biology and disease. APC is implicated in RNA localization,…”
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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons by Muratore, Christina R, Rice, Heather C, Srikanth, Priya, Callahan, Dana G, Shin, Taehwan, Benjamin, Lawrence N P, Walsh, Dominic M, Selkoe, Dennis J, Young-Pearse, Tracy L

“…Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by extracellular plaques containing amyloid β (Aβ)-protein and intracellular…”
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Comparison and optimization of hiPSC forebrain cortical differentiation protocols by Muratore, Christina R, Srikanth, Priya, Callahan, Dana G, Young-Pearse, Tracy L

“…Several protocols have been developed for human induced pluripotent stem cell neuronal differentiation. We compare several methods for forebrain cortical…”
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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration by Neel, Dylan V., Basu, Himanish, Gunner, Georgia, Bergstresser, Matthew D., Giadone, Richard M., Chung, Haeji, Miao, Rui, Chou, Vicky, Brody, Eliza, Jiang, Xin, Lee, Edward, Watts, Michelle E., Marques, Christine, Held, Aaron, Wainger, Brian, Lagier-Tourenne, Clotilde, Zhang, Yong-Jie, Petrucelli, Leonard, Young-Pearse, Tracy L., Chen-Plotkin, Alice S., Rubin, Lee L., Lieberman, Judy, Chiu, Isaac M.

“…Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate…”
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C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death by Kanmert, Daniel, Cantlon, Adam, Muratore, Christina R, Jin, Ming, O'Malley, Tiernan T, Lee, Gloria, Young-Pearse, Tracy L, Selkoe, Dennis J, Walsh, Dominic M

“…Recent evidence suggests that tau aggregation may spread via extracellular release and subsequent uptake by synaptically connected neurons, but little is known…”
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PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins by Corbett, Grant T., Wang, Zemin, Hong, Wei, Colom-Cadena, Marti, Rose, Jamie, Liao, Meichen, Asfaw, Adhana, Hall, Tia C., Ding, Lai, DeSousa, Alexandra, Frosch, Matthew P., Collinge, John, Harris, David A., Perkinton, Michael S., Spires-Jones, Tara L., Young-Pearse, Tracy L., Billinton, Andrew, Walsh, Dominic M.

“…Neurodegenerative diseases are an enormous public health problem, affecting tens of millions of people worldwide. Nearly all of these diseases are…”
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Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons by Hsieh, Yi‐Chen, Augur, Zachary M., Arbery, Mason, Ashour, Nancy, Barrett, Katharine, Pearse, Richard V., Tio, Earvin S., Duong, Duc M., Felsky, Daniel, De Jager, Philip L., Bennett, David A., Seyfried, Nicholas T., Young‐Pearse, Tracy L.

“…BACKGROUND Impairment of the ubiquitin‐proteasome system (UPS) has been implicated in abnormal protein accumulation in Alzheimer's disease. It remains unclear…”
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Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate by Srikanth, Priya, Han, Karam, Callahan, Dana G., Makovkina, Eugenia, Muratore, Christina R., Lalli, Matthew A., Zhou, Honglin, Boyd, Justin D., Kosik, Kenneth S., Selkoe, Dennis J., Young-Pearse, Tracy L.

“…Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is…”
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Somatic mosaicism of sex chromosomes in the blood and brain by Graham, Emma J., Vermeulen, Michael, Vardarajan, Badri, Bennett, David, De Jager, Phil, Pearse, Richard V., Young-Pearse, Tracy L., Mostafavi, Sara

“…•Somatic mosaicism (SM) of the Y chr. occurs more frequently in blood than brain.•SM of the Y and female X chr. are associated with aggregate gene…”
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INPP5D regulates inflammasome activation in human microglia by Chou, Vicky, Pearse, Richard V., Aylward, Aimee J., Ashour, Nancy, Taga, Mariko, Terzioglu, Gizem, Fujita, Masashi, Fancher, Seeley B., Sigalov, Alina, Benoit, Courtney R., Lee, Hyo, Lam, Matti, Seyfried, Nicholas T., Bennett, David A., De Jager, Philip L., Menon, Vilas, Young-Pearse, Tracy L.

“…Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (…”
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Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing by Nguyen, Lien D., Wei, Zhiyun, Silva, M. Catarina, Barberán-Soler, Sergio, Zhang, Jiarui, Rabinovsky, Rosalia, Muratore, Christina R., Stricker, Jonathan M. S., Hortman, Colin, Young-Pearse, Tracy L., Haggarty, Stephen J., Krichevsky, Anna M.

“…MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or…”
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Barriers and facilitators to implementing evidence based bleeding management in Australian Cardiac Surgery Units: a qualitative interview study analysed with the theoretical domains framework and COM-B model by Pearse, Bronwyn L., Keogh, Samantha, Rickard, Claire M., Fung, Yoke L.

“…Abstract Background Bleeding during cardiac surgery is a common complication that often requires the transfusion of blood products. The combination of bleeding…”
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Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model by Palotai, Miklos, Schregel, Katharina, Nazari, Navid, Merchant, Julie P., Taylor, Walter M., Guttmann, Charles R. G., Sinkus, Ralph, Young‐Pearse, Tracy L., Patz, Samuel

“…Background and Purpose Biomechanical changes in the brain have not been fully elucidated in Alzheimer's disease (AD). We aimed to investigate the effect of…”
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Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids by Srikanth, Priya, Lagomarsino, Valentina N., Muratore, Christina R., Ryu, Steven C., He, Amy, Taylor, Walter M., Zhou, Constance, Arellano, Marlise, Young-Pearse, Tracy L.

“…The development of three-dimensional culture methods has allowed for the study of developing cortical morphology in human cells. This provides a new tool to…”
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Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model by Rice, Heather C, Marcassa, Gabriele, Chrysidou, Iordana, Horré, Katrien, Young-Pearse, Tracy L, Müller, Ulrike C, Saito, Takashi, Saido, Takaomi C, Vassar, Robert, de Wit, Joris, De Strooper, Bart

“…The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer's disease (AD) brains, is derived from sequential proteolytic…”
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Protocol guided bleeding management improves cardiac surgery patient outcomes by Pearse, B. L., Smith, I., Faulke, D., Wall, D., Fraser, J. F., Ryan, E. G., Drake, L., Rapchuk, I. L., Tesar, P., Ziegenfuss, M., Fung, Y. L.

“…Background and Objectives Excessive bleeding is a risk associated with cardiac surgery. Treatment invariably requires transfusion of blood products; however,…”
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Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1 by Lee, Hyo, Aylward, Aimee J., Pearse, Richard V., Lish, Alexandra M., Hsieh, Yi-Chen, Augur, Zachary M., Benoit, Courtney R., Chou, Vicky, Knupp, Allison, Pan, Cheryl, Goberdhan, Srilakshmi, Duong, Duc M., Seyfried, Nicholas T., Bennett, David A., Taga, Mariko F., Huynh, Kevin, Arnold, Matthias, Meikle, Peter J., De Jager, Philip L., Menon, Vilas, Young, Jessica E., Young-Pearse, Tracy L.

“…SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null…”
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Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development by Young-Pearse, Tracy L, Suth, Seiyam, Luth, Eric S, Sawa, Akira, Selkoe, Dennis J

“…Although clinically distinct, schizophrenia and Alzheimer's disease are common and devastating disorders that profoundly impair cognitive function. For…”
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Targeted Bleeding Management Reduces the Requirements for Blood Component Therapy in Lung Transplant Recipients by Smith, Ian, MBChB, FANZCA, Pearse, Bronwyn L., RN, MClPract, Faulke, Daniel J., MBChB, FANZCA, Naidoo, Rishen, FRACS, Nicotra, Lisa, RN, BHSc, Hopkins, Peter, FRACP, Ryan, Elizabeth G., PhD

“…Objective Lung transplantation is associated with high rates of bleeding and frequent blood transfusion. The authors aimed to determine if point-of-care…”
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