Search Results - "PAZDRAK, Barbara"

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy by Sharma, Meenu, Khong, Hiep, Fa’ak, Faisal, Bentebibel, Salah-Eddine, Janssen, Louise M. E., Chesson, Brent C., Creasy, Caitlin A., Forget, Marie-Andrée, Kahn, Laura Maria S., Pazdrak, Barbara, Karki, Binisha, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Vennam, Srinivas, Bharadwaj, Uddalak, Tweardy, David J., Haymaker, Cara, Bernatchez, Chantale, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Hurwitz, Michael E., Sznol, Mario, Hwu, Patrick, Hoch, Ute, Addepalli, Murali, Charych, Deborah H., Zalevsky, Jonathan, Diab, Adi, Overwijk, Willem W.

“…High dose interleukin-2 (IL-2) is active against metastatic melanoma and renal cell carcinoma, but treatment-associated toxicity and expansion of suppressive…”
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Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes by Sonnemann, Heather M, Pazdrak, Barbara, Nassif, Barbara, Sun, Yimo, Elzohary, Lama, Talukder, Amjad H, Katailiha, Arjun S, Bhat, Krishna, Lizée, Gregory

“…Vestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain-containing transcription factors (TEADs). Its expression is upregulated in…”
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Human Lactoferrin Synergizes with Etoposide to Inhibit Lung Adenocarcinoma Cell Growth While Attenuating Etoposide-Mediated Cytotoxicity of Human Endothelial Cells by Olszewska, Paulina, Pazdrak, Barbara, Kruzel, Marian L

“…Lung cancer continues to be the deadliest cancer worldwide. A new strategy of combining chemotherapeutics with naturally occurring anticancer compounds, such…”
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Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells by Olszewska-Pazdrak, Barbara, Hein, Travis W, Olszewska, Paulina, Carney, Darrell H

“…Coronary artery disease results in progressive vascular stenosis associated with chronic myocardial ischemia. Vascular endothelial growth factor (VEGF)…”
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Cell-Specific Expression of RANTES, MCP-1, and MIP-1α by Lower Airway Epithelial Cells and Eosinophils Infected with Respiratory Syncytial Virus by Olszewska-Pazdrak, Barbara, Casola, Antonella, Saito, Tadahito, Alam, Rafeul, Crowe, Sheila E., Mei, Fang, Ogra, Pearay L., Garofalo, Roberto P.

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation by Pazdrak, K, Olszewska-Pazdrak, B, Stafford, S, Garofalo, R P, Alam, R

“…Interleukin (IL)-5 has been shown to activate many signaling molecules in eosinophils, but their functional relevance remains unknown. We have examined the…”
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Thrombin peptide TP508 stimulates rapid nitric oxide production in human endothelial cells by Olszewska-Pazdrak, Barbara, Hart-Vantassell, Audrey, Carney, Darrell H

“…TP508, a 23-amino-acid peptide representing a portion of human thrombin, promotes tissue revascularization and repair. The molecular mechanisms of TP508…”
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Vestigial-like 1 (VGLL1): An ancient co-transcriptional activator linking wing, placenta, and tumor development by Sonnemann, Heather M., Pazdrak, Barbara, Antunes, Dinler A., Roszik, Jason, Lizée, Gregory

“…Vestigial-like 1 (VGLL1) is a recently discovered driver of proliferation and invasion that is expressed in many aggressive human malignancies and is strongly…”
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Abstract 70: Obesity-induced impairment of antitumor immunity is associated with an immunosuppressive tumor immune landscape by Pazdrak, Barbara, Mak, Duncan, Damsky, William, Bosenberg, Marcus, Lochmann, Brooklyn, Gubin, Matthew, McQuade, Jennifer

“…Abstract Obesity is associated with an increased risk and progression in a variety of cancers. In melanoma, obesity is associated with an increased risk of…”
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Agonist-independent Activation of Src Tyrosine Kinase by a Cholecystokinin-2 (CCK2) Receptor Splice Variant by Olszewska-Pazdrak, Barbara, Townsend, Courtney M., Hellmich, Mark R.

“…Src activity is elevated in a majority of colonic and pancreatic cancers and is associated with late stage aggressive cancers. However, the mechanisms leading…”
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MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression by Pazdrak, Konrad, Olszewska-Pazdrak, Barbara, Liu, Tianshuang, Takizawa, Ryuta, Brasier, Allan R, Garofalo, Roberto P, Casola, Antonella

“…Airway epithelial cells represent the primary cell target of respiratory syncytial virus (RSV) infection. They actively participate in the lung…”
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A Novel Human Recombinant Lactoferrin Inhibits Lung Adenocarcinoma Cell Growth and Migration with No Cytotoxic Effect on Normal Human Epithelial Cells by Olszewska, Paulina, Pazdrak, Barbara, Kruzel, Marian L.

“…Lung cancer remains the leading cause of cancer death worldwide. Despite the recent advances in cancer treatment, only a subset of patients responds to…”
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Cross-Talk between ICAM-1 and GM-CSF Receptor Signaling Modulates Eosinophil Survival and Activation by Pazdrak, Konrad, Young, Travis W, Stafford, Susan, Olszewska-Pazdrak, Barbara, Straub, Christof, Starosta, Vitaliy, Brasier, Allan, Kurosky, Alexander

“…Abstract Reversal of eosinophilic inflammation has been an elusive therapeutic goal in the management of asthma pathogenesis. In this regard, GM-CSF is a…”
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Abstract 5079: Intratumoral CD40 agonist enhances the antitumor effect of anti-PD1 immunotherapy by activation of antigen-presenting cells and selective expansion of effector CD8+ T cells by Pazdrak, Barbara, Sonnemann, Heather M., Bentebibel, Salah-Eddine, Nassif, Barbara M., Lizee, Greg, Diab, Adi

“…Abstract Agonistic CD40 antibodies have shown promise when used in combination with checkpoint inhibitors in clinical trials for the treatment of malignancies…”
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Epidermal Growth Factor Potentiates Cholecystokinin/Gastrin Receptor-mediated Ca2+ Release by Activation of Mitogen-activated Protein Kinases by Olszewska-Pazdrak, Barbara, Ives, Kirk L., Park, Jeseong, Townsend, Courtney M., Hellmich, Mark R.

“…Small differences in amplitude, duration, and temporal patterns of change in the concentration of free intracellular Ca2+ ([Ca2+]i) can profoundly affect cell…”
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Abstract 1485: Elucidating the role of VGLL1 in pancreatic cancer tumorigenesis by Sonnemann, Heather M., Pazdrak, Barbara, Nassif, Barbara, Sun, Yimo, Elzohary, Lama, Talukder, Amjad, Katailiha, Arjun, Bentebibel, Salah-Eddine, Diab, Adi, Lizee, Gregory

“…Abstract Vestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain-containing transcription factors (TEADs). Its expression is…”
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Respiratory Syncytial Virus-Infected Pulmonary Epithelial Cells Induce Eosinophil Degranulation by a CD18-Mediated Mechanism by Olszewska-Pazdrak, Barbara, Pazdrak, Konrad, Ogra, Pearay L, Garofalo, Roberto P

“…Respiratory syncytial virus (RSV)-induced bronchiolitis in infants is characterized by wheezing, respiratory distress, and the histologic findings of necrosis…”
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Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia by Olszewska-Pazdrak, Barbara, Carney, Darrell H

“…Revascularization of chronic wounds and ischemic tissue is attenuated by endothelial dysfunction and the inability of angiogenic factors to stimulate…”
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782 Intratumoral sotigalimab with pembrolizumab activates antigen-presenting cells and induces local and distant anti-tumor responses in first-line metastatic melanoma: results of a phase I/II study by Salah-Eddine Bentebibel, Johnson, Daniel, Pazdrak, Barbara, McGrail, Daniel, Lecagoonporn, Srisuda, Haymaker, Cara, Duose, Dzifa Y, Wani, Khalida, Sonnemann, Heather, Safa, Houssein, Burks, Jared K, Hwu, Patrick, cho Sungnam, Bernatchez, Chantale, Ekmekcioglu, Suhendan, Lizée, Gregory, Diab, Adi

“…BackgroundCheckpoint inhibitors (CPI) provide significant clinical benefits for patients with metastatic melanoma (MM). However, the majority of patients do…”
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Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair by Olszewska-Pazdrak, Barbara, McVicar, Scott D., Rayavara, Kempaiah, Moya, Stephanie M., Kantara, Carla, Gammarano, Chris, Olszewska, Paulina, Fuller, Gerald M., Sower , Laurie E., Carney , Darrell H.

“…There is increasing evidence that radiation-induced damage to endothelial cells and loss of endothelial function may contribute to both acute radiation…”
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