Search Results - "PAUWELS, Petrus J"

A recombinant humanized anti‐insulin‐like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti‐epidermal growth factor receptor therapy against human cancer xenografts by Goetsch, Liliane, Gonzalez, Alexandra, Leger, Olivier, Beck, Alain, Pauwels, Petrus J., Haeuw, Jean François, Corvaia, Nathalie

“…Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of…”
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Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial) by Verry, Camille, Dufort, Sandrine, Villa, Julie, Gavard, Marylaure, Iriart, Carole, Grand, Sylvie, Charles, Julie, Chovelon, Benoit, Cracowski, Jean-Luc, Quesada, Jean-Louis, Mendoza, Christophe, Sancey, Lucie, Lehmann, Audrey, Jover, Florence, Giraud, Jean-Yves, Lux, François, Crémillieux, Yannick, McMahon, Stephen, Pauwels, Petrus J., Cagney, Daniel, Berbeco, Ross, Aizer, Ayal, Deutsch, Eric, Loeffler, Markus, Le Duc, Géraldine, Tillement, Olivier, Balosso, Jacques

“…•Administration of theranostics AGuIX nanoparticles is safe and feasible in patients with brain metastases.•Brain metastases are detected by MRI up to 1 week…”
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Determination of risks of lower adherence to CPAP treatment before their first use by patients by Bros, Julie, Poulet, Caroline, Methni, Jonathan El, Deschaux, Chrystèle, Gandit, Marc, Pauwels, Petrus J, Charavel, Marie

“…A better understanding of Continuous Positive Airway Pressure (CPAP) adherence is a priority in improving patient care. To Identify adherence typology with a…”
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5-HT1A receptor activation and antidepressant-like effects : F 13714 has high efficacy and marked antidepressant potential by KOEK, Wouter, VACHER, Bernard, COSI, Cristina, ASSIE, Marie-Bernadette, PATOISEAU, Jean-Francois, PAUWELS, Petrus J, COLPAERT, Francis C

“…To examine further the hypothesis that the magnitude of the intrinsic activity of agonists at 5-HT1A receptors determines the magnitude of their psychotropic…”
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Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents by HOLENZ, Jörg, PAUWELS, Petrus J, DIAZ, José Luis, MERCE, Ramon, CODONY, Xavier, BUSCHMANN, Helmut

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Efficacy of selective 5‐HT6 receptor ligands determined by monitoring 5‐HT6 receptor‐mediated cAMP signaling pathways by Romero, Gonzalo, Sánchez, Elisabeth, Pujol, Marta, Pérez, Pilar, Codony, Xavier, Holenz, Jörg, Buschmann, Helmut, Pauwels, Petrus J

“…1 Two novel selective 5‐HT6 receptor ligands E‐6801 (6‐chloro‐N‐(3‐(2‐(dimethylamino)ethyl)‐1H‐indol‐5‐yl)imidazo[2,1‐b]thiazole‐5‐sulfonamide) and E‐6837…”
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Reanalysis of constitutively active rat and human 5-HT7(a) receptors in HEK-293F cells demonstrates lack of silent properties for reported neutral antagonists by Romero, Gonzalo, Pujol, Marta, Pauwels, Petrus J

“…The present study reinvestigated a series of 5-HT receptor antagonists at both constitutively active rat and human 5-HT7(a) receptors in HEK-293F cells using…”
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Transferability of health cost evaluation across locations in oncology: cluster and principal component analysis as an explorative tool by Perrier, Lionel, Buja, Alessandra, Mastrangelo, Giuseppe, Baron, Patrick Sylvestre, Ducimetière, Françoise, Pauwels, Petrus J, Rossi, Carlo Riccardo, Gilly, François Noël, Martin, Amaury, Favier, Bertrand, Farsi, Fadila, Laramas, Mathieu, Baldo, Vincenzo, Collard, Olivier, Cellier, Dominic, Blay, Jean-Yves, Ray-Coquard, Isabelle

“…The transferability of economic evaluation in health care is of increasing interest in today's globalized environment. Here, we propose a methodology for…”
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Diverse signalling by 5-hydroxytryptamine (5-HT) receptors by Pauwels, Petrus J

“…Fourteen different receptor subtypes might be regarded as a diversity that is sufficient to accommodate the wide-ranging physiological roles of…”
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Unravelling multiple ligand-activation binding sites using RASSL receptors by Pauwels, Petrus J

“…The principle of receptors activated solely by synthetic ligands (RASSLs) as discovered for chimeric opioid peptide receptors has been extended to…”
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Whole spectrum analysis of ligand efficacy at constitutively active human wild-type and S267K 5-HT6 receptors in HEK-293F cells by Romero, Gonzalo, Pujol, Marta, Pérez, Pilar, Buschmann, Helmut, Pauwels, Petrus J.

“…Introduction: Modulation of constitutive activity by the recombinant wild-type human 5-HT6 receptor was investigated with a series of 5-HT6 receptor ligands by…”
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7th Cancer Scientific Forum of the Cancéropôle Lyon Auvergne Rhône-Alpes: March 20–21, 2012, Lyon, France by Pauwels, Petrus J., Dumontet, Charles, Reichert, Janice M., Beck, Alain, Goetsch, Liliane, Corvaïa, Nathalie, Klein, Christian, Coiffier, Bertrand, Teicher, Beverly A.

“…The Innovative Approaches in Anti-Cancer Monoclonal Antibodies meeting, held on March 20, 2012 in Lyon, was organized by Cancéropôle Lyon Auvergne-Rhône-Alps…”
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Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptors by Perez, Michel, Fourrier, Catherine, Sigogneau, Isabelle, Pauwels, Petrus J, Palmier, Christiane, John, Gareth W, Valentin, Jean-Pierre, Halazy, Serge

“…A series of new arylpiperazide derivatives of serotonin has been prepared and evaluated as 5-HT1D receptor agonists. Binding experiments at cloned human 5-HT1D…”
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Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation by Pauwels, Petrus J, Colpaert, Francis C

“…Little experimental evidence has been reported for diverse signaling via 5-hydroxytryptamine (5-HT)1A receptors despite the fact that agonists seem to be more…”
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La France peine à transformer son excellence scientifique en applications concrètes contre le cancer by Pauwels, Petrus J, Lévy, Laurent

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Modulation of ligand responses by coupling of α2A-adrenoceptors to diverse Gα-proteins by PAUWELS, Petrus J, TARDIF, Stéphanie, COLPAERT, Francis C, WURCH, Thierry

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Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht1F receptor by BHALLA, Pankaj, SHARMA, Hari S, WURCH, Thierry, PAUWELS, Petrus J, SAXENA, Pramod R

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Serotonin Dimers:  Application of the Bivalent Ligand Approach to the Design of New Potent and Selective 5-HT1B/1D Agonists by Halazy, Serge, Perez, Michel, Fourrier, Catherine, Pallard, Isabelle, Pauwels, Petrus J, Palmier, Christiane, John, Gareth W, Valentin, Jean-Pierre, Bonnafous, Régine, Martinez, Jean

“…A series of serotonin dimers of formula 4 in which two serotonin moeities are linked together through their 5-hydroxyl residue has been prepared and evaluated…”
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Molecular cloning, pharmacological properties and tissue distribution of the porcine 5‐HT1B receptor by Bhalla, Pankaj, Sharma, Hari S, Ma, Xiaoqian, Wurch, Thierry, Pauwels, Petrus J, Saxena, Pramod R

“…Using a combination of RT – PCR and inverse‐PCR techniques, we amplified, cloned and sequenced a full‐length porcine 5‐HT1B receptor cDNA derived from porcine…”
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Different regulation of RGS2 mRNA by haloperidol and clozapine by Robinet, Elisa A, Wurch, Thierry, Pauwels, Petrus J

“…Expression of RGS2 mRNA was transiently up-regulated in rat striatum (25% in the medial part and 50% in the lateral part), in contrast to cingulate cortex and…”
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