Search Results - "PAULOSE, C. S"

GABA and 5-HT chitosan nanoparticles decrease striatal neuronal degeneration and motor deficits during liver injury by Shilpa, J., Paulose, C. S.

“…The metabolic alterations resulted from hepatic injury and cell loss lead to synaptic defects and neurodegeneration that undoubtedly contribute motor deficits…”
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Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A by Mathew, Jobin, Balakrishnan, Savitha, Antony, Sherin, Abraham, Pretty Mary, Paulose, C S

“…Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances…”
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Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats by Kumar, T Peeyush, Antony, Sherin, Gireesh, G, George, Naijil, Paulose, C S

“…Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory…”
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Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats by Sherin, A, Anu, J, Peeyush, K.T, Smijin, S, Anitha, M, Roshni, B.T, Paulose, C.S

“…Abstract Neurotransmitter receptor functional regulation plays an important role in controlling the excitability and responsiveness of hippocampal neurons…”
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Behavioral Deficit and Decreased GABA Receptor Functional Regulation in the Hippocampus of Epileptic Rats: Effect of Bacopa monnieri by Mathew, Jobin, Gangadharan, Gireesh, Kuruvilla, Korah P., Paulose, C. S.

“…In the present study, alterations of the General GABA and GABA A receptors in the hippocampus of pilocarpine-induced temporal lobe epileptic rats and the…”
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Role of GABA and serotonin coupled chitosan nanoparticles in enhanced hepatocyte proliferation by Shilpa, J., Roshni, B. T., Chinthu, R., Paulose, C. S.

“…The development of nanoparticles containing active molecules having improved stability, sustained release and maximum half life helps in cell proliferation…”
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Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture by Gireesh, G., Thomas, Santhosh K., Joseph, Binoy, Paulose, C.S.

“…The leaves of Costus pictus D. Don were used extensively for its antihyperglycemic activity by the people in Kerala, India. In the present study, the…”
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Enhanced Dopamine D1 and D2 Receptor Gene Expression in the Hippocampus of Hypoglycaemic and Diabetic Rats by Robinson, Remya, Krishnakumar, Amee, Paulose, C. S

“…Hypoglycaemic coma and brain injury are potential complications of insulin therapy. Hippocampal neurons are particularly vulnerable to hypoglycaemic stress…”
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Decreased GABA Receptor Binding in the Cerebral Cortex of Insulin Induced Hypoglycemic and Streptozotocin Induced Diabetic Rats by Antony, Sherin, Peeyush Kumar, T., Kuruvilla, Korah P., George, Naijil, Paulose, C. S.

“…Hypoglycemia is the major problem to blood glucose homeostasis in treatment of diabetes and is associated with severe irreversible consequences including…”
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Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose by Abraham, Pretty Mary, Kuruvilla, Korah P, Mathew, Jobin, Malat, Anitha, Joy, Shilpa, Paulose, C S

“…Diabetes and stress stimulate hippocampal 5-HT synthesis, metabolism and release. The present study was carried out to find the effects of insulin, Aegle…”
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Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats by George, Naijil, Peeyush Kumar, T., Antony, Sherin, Jayanarayanan, S., Paulose, C. S.

“…Diabetes mellitus is a growing health problem worldwide and is associated with severe liver complications. The aim of the present study is to analyse the…”
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Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats by Joseph, A, Antony, S, Paulose, C.S

“…Abstract Hypoglycemia causes brain fuel deprivation, resulting in functional brain failure and brain death. It is a serious complication of insulin therapy in…”
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Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: Functional regulation with Vitamin D3 supplementation by PEEYUSH, Kumar T, SAVITHA, Balakrishnan, SHERIN, Antony, ANJU, T. R, JES, Paul, PAULOSE, C. S

“…The study was to find out the effect of Vitamin D3 supplementation on preventing the altered gene expression of cholinergic, dopaminergic, insulin receptors…”
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Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of unilateral 6-hydroxydopamine induced Parkinson's rats: effect of 5-HT, GABA and bone marrow cell supplementation by Nandhu, M S, Paul, Jes, Kuruvilla, Korah P, Malat, Anitha, Romeo, Chinthu, Paulose, C S

“…Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and…”
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Disruption of cerebellar cholinergic system in hypoxic neonatal rats and its regulation with glucose, oxygen and epinephrine resuscitations by Anju, T.R, Ajayan, M.S, Paulose, C.S

“…Graphical abstract Highlights ► Cerebellar muscarinic M1/2/3 receptor was decreased due to neonatal hypoxia. ► Acetylcholine metabolism was also disturbed –…”
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Alterations in cortical GABAB receptors in neonatal rats exposed to hypoxic stress: role of glucose, oxygen, and epinephrine resuscitation by Anju, T. R, Abraham, Pretty Mary, Antony, Sherin, Paulose, C. S

“…Hypoxia in neonates can cause permanent brain damage by gene and receptor level alterations mediated through changes in neurotransmitters. The present study…”
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Increased cortical neuronal survival during liver injury: effect of gamma aminobutyric acid and 5-HT chitosan nanoparticles by Shilpa, J, Anju, T R, Ajayan, M S, Paulose, C S

“…Use of nanoparticulate drug delivery system for an effective therapeutic outcome against diseases gains immense hope in the study of drug delivery to partially…”
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Dopaminergic regulation of glucose‐induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro by Shankar, Eswar, Santhosh, K. T., Paulose, C. S.

“…The stimulatory effect of dopamine through dopamine D2 receptor on glucose‐induced insulin secretion was studied in the pancreatic islets in vitro. Dopamine…”
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Cortical cholinergic dysregulation as a long-term consequence of neonatal hypoglycemia by Anju, T R, Paulose, C S

“…Neonatal hypoglycemia limits the glucose supply to cells, affecting the function of brain due to its high energy demand. This can cause long-term consequences…”
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Serotonergic receptor upregulation in cerebral cortex and down regulation in brainstem of streptozotocin induced diabetic rats: Antagonism by pyridoxine and insulin by Abraham, Pretty Mary, Anju, T.R., Jayanarayanan, S., Paulose, C.S.

“…Insulin secretion and glucose homeostasis is implicated through serotonergic function. Pyridoxine is involved in decarboxylation step in synthesis of…”
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