Search Results - "PAULA, A. C."

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents by Stokes, Barbara H, Yoo, Euna, Murithi, James M, Luth, Madeline R, Afanasyev, Pavel, da Fonseca, Paula C A, Winzeler, Elizabeth A, Ng, Caroline L, Bogyo, Matthew, Fidock, David A

“…Therapeutics with novel modes of action and a low risk of generating resistance are urgently needed to combat drug-resistant Plasmodium falciparum malaria…”
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Structure- and function-based design of Plasmodium-selective proteasome inhibitors by Li, Hao, O’Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew

“…Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human…”
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Structural basis for the subunit assembly of the anaphase-promoting complex by Schreiber, Anne, Stengel, Florian, Zhang, Ziguo, Enchev, Radoslav I., Kong, Eric H., Morris, Edward P., Robinson, Carol V., da Fonseca, Paula C. A., Barford, David

“…The anaphase-promoting complex or cyclosome (APC/C) is an unusually large E3 ubiquitin ligase responsible for regulating defined cell cycle transitions…”
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How to build a proteasome by Morris, Edward P., da Fonseca, Paula C. A.

“…The biogenesis of eukaryotic 20S proteasomes requires the accurate assembly of 14 closely related protein subunits and occurs in a complex series of…”
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The cryo‐EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria by Li, Hao, Bogyo, Matthew, Fonseca, Paula C. A.

“…Plasmodium falciparum is the parasite responsible for the most severe form of malaria. Its increasing resistance to existing antimalarials represents a major…”
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The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites by Santos, Viviane Corrêa, Oliveira, Antonio Edson Rocha, Campos, Augusto César Broilo, Reis-Cunha, João Luís, Bartholomeu, Daniella Castanheira, Teixeira, Santuza Maria Ribeiro, Lima, Ana Paula C. A., Ferreira, Rafaela Salgado

“…Cruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi , the protozoan parasite that causes Chagas disease. Encoded by a multigenic…”
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Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host by Levy, David Jessula, Goundry, Amy, Laires, Raquel S S, Costa, Tatiana F R, Novo, Carlos Mendes, Grab, Dennis J, Mottram, Jeremy C, Lima, Ana Paula C A

“…Trypanosoma brucei rhodesiense is one of the causative agents of Human African Trypanosomiasis (HAT), known as sleeping sickness. The parasite invades the…”
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Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice by DeSouza-Vieira, Thiago, Pretti, Marco Antônio M, Lima Gomes, Phillipe Souza, Paula-Neto, Heitor A, Goundry, Amy, Nascimento, Michelle T, Ganesan, Sundar, Gonçalves da Silva, Triciana, Kamenyeva, Olena, Kabat, Juraj, Manzella-Lapeira, Javier, B Canto, Fábio, Fraga-Junior, Vanderlei da Silva, Eustáquio Lopes, Mateus, Gomes Vaz, Leonardo, Pessenda, Gabriela, Paun, Andrea, Freitas-Mesquita, Anita L, Meyer-Fernandes, José Roberto, Boroni, Mariana, Bellio, Maria, Batista Menezes, Gustavo, Brzostowski, Joseph, Mottram, Jeremy, Sacks, David, Lima, Ana Paula C A, Saraiva, Elvira M

“…Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release and phagocytosis…”
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Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis by Živković, Dušan, Sanchez Dafun, Angelique, Menneteau, Thomas, Schahl, Adrien, Lise, Sandrine, Kervarrec, Christine, Toste Rêgo, Ana, da Fonseca, Paula C A, Chavent, Matthieu, Pineau, Charles, Burlet-Schiltz, Odile, Marcoux, Julien, Bousquet, Marie-Pierre

“…During spermatogenesis, spermatogonia undergo a series of mitotic and meiotic divisions on their path to spermatozoa. To achieve this, a succession of…”
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Optical sensors and biosensors based on sol–gel films by JERONIMO, Paula C. A, ARAUJO, Alberto N, MONTENEGRO, M. Conceicao B. S. M

“…The sol–gel technology is being increasingly used for the development of optical sensors and biosensors, due to its simplicity and versatility. By this…”
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Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response by Costa, Tatiana F R, Goundry, Amy, Morrot, Alexandre, Grab, Dennis J, Mottram, Jeremy C, Lima, Ana Paula C A

“…The protozoan causes Human African Trypanosomiasis, also known as sleeping sickness, and penetrates the central nervous system, leading to meningoencephalitis…”
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Peptide-Based Drugs and Drug Delivery Systems by Galdiero, Stefania, Gomes, Paula A C

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Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects by Jones, Nathaniel G, Catta-Preta, Carolina M. C, Lima, Ana Paula C. A, Mottram, Jeremy C

“…There has been a very limited number of high-throughput screening campaigns carried out with Leishmania drug targets. In part, this is due to the small number…”
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Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review by Costa, Bruna, Martínez-de-Tejada, Guillermo, Gomes, Paula A C, L Martins, M Cristina, Costa, Fabíola

“…Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and…”
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Tissue Specific Dual RNA-Seq Defines Host-Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum by Forrester, Sarah, Goundry, Amy, Dias, Bruna Torres, Leal-Calvo, Thyago, Moraes, Milton Ozório, Kaye, Paul M, Mottram, Jeremy C, Lima, Ana Paula C A

“…Visceral leishmaniasis is associated with hepato-splenomegaly and altered immune and hematological parameters in both preclinical animal models and humans. We…”
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Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C) by Zhang, Ziguo, Yang, Jing, Kong, Eric H, Chao, William C H, Morris, Edward P, da Fonseca, Paula C A, Barford, David

“…Mechanistic and structural studies of large multi-subunit assemblies are greatly facilitated by their reconstitution in heterologous recombinant systems. In…”
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Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages by Dias, Bruna T, Goundry, Amy, Vivarini, Aislan C, Costa, Tatiana F R, Mottram, Jeremy C, Lopes, Ulisses G, Lima, Ana Paula C A

“…is a protozoan parasite that causes visceral leishmaniasis, provoking liver and spleen tissue destruction that is lethal unless treated. The parasite…”
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Dhvar5 antimicrobial peptide (AMP) chemoselective covalent immobilization results on higher antiadherence effect than simple physical adsorption by Costa, Fabíola M.T.A, Maia, Sílvia R, Gomes, Paula A.C, Martins, M. Cristina L

“…Abstract Bacterial colonization and subsequent biofilm formation is still one of the major problems associated with medical devices. Antimicrobial peptides…”
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The hidden curve behind COVID-19 outbreak: the impact of delay in treatment initiation in cancer patients and how to mitigate the additional risk of dying—the head and neck cancer model by Matos, Leandro L., Forster, Carlos Henrique Q., Marta, Gustavo N., Castro Junior, Gilberto, Ridge, John A., Hirata, Daisy, Miranda-Filho, Adalberto, Hosny, Ali, Sanabria, Alvaro, Gregoire, Vincent, Patel, Snehal G., Fagan, Johannes J., D’Cruz, Anil K., Licitra, Lisa, Mehanna, Hisham, Hao, Sheng-Po, Psyrri, Amanda, Porceddu, Sandro, Galloway, Thomas J., Golusinski, Wojciech, Lee, Nancy Y., Shiguemori, Elcio H., Matieli, José Elias, Shiguemori, Ana Paula A. C., Diamantino, Letícia R., Schiaveto, Luiz Felipe, Leão, Lysia, Castro, Ana F., Carvalho, André Lopes, Kowalski, Luiz Paulo

“…Purpose The rapid spread of the SARS-CoV-2 pandemic around the world caused most healthcare services to turn substantial attention to treatment of these…”
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Crovirin, a snake venom cysteine-rich secretory protein (CRISP) with promising activity against Trypanosomes and Leishmania by Adade, Camila M, Carvalho, Ana Lúcia O, Tomaz, Marcelo A, Costa, Tatiana F R, Godinho, Joseane L, Melo, Paulo A, Lima, Ana Paula C A, Rodrigues, Juliany C F, Zingali, Russolina B, Souto-Padrón, Thaïs

“…The neglected human diseases caused by trypanosomatids are currently treated with toxic therapy with limited efficacy. In search for novel anti-trypanosomatid…”
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