Search Results - "PAUL, Christer"

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer by LEHMANN, Sören, BYKOV, Vladimir J. N, PAUL, Christer, WIMAN, Klas G, ANDERSSON, Per-Ola, ALI, Dina, ANDREN, Ove, CHERIF, Honar, TIDEFELT, Ulf, UGGLA, Bertil, YACHNIN, Jeffrey, JULIUSSON, Gunnar, MOSHFEGH, Ali

“…APR-246 (PRIMA-1MET) is a novel drug that restores transcriptional activity of unfolded wild-type or mutant p53. The main aims of this first-in-human trial…”
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Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks by Deneberg, Stefan, Guardiola, Philippe, Lennartsson, Andreas, Qu, Ying, Gaidzik, Verena, Blanchet, Odile, Karimi, Mohsen, Bengtzén, Sofia, Nahi, Hareth, Uggla, Bertil, Tidefelt, Ulf, Höglund, Martin, Paul, Christer, Ekwall, Karl, Döhner, Konstanze, Lehmann, Sören

“…Cytogenetically normal acute myeloid leukemia (CN-AML) compose between 40% and 50% of all adult acute myeloid leukemia (AML) cases. In this clinically diverse…”
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Daunorubicin metabolism in leukemic cells isolated from patients with acute myeloid leukemia by Bogason, Alex, Masquelier, Michéle, Lafolie, Pierre, Skogastierna, Cristine, Paul, Christer, Gruber, Astrid, Vitols, Sigurd

“…Anthracyclines like daunorubicin (DNR) are important drugs in the treatment of acute myeloid leukaemia (AML). In vitro studies have shown that cellular…”
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Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity by Björkhem-Bergman, Linda, Jönsson, Kerstin, Eriksson, Lennart C., Olsson, Jerker M., Lehmann, Sören, Paul, Christer, Björnstedt, Mikael

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Anti‐leukaemic effects induced by APR‐246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells by Ali, Dina, Mohammad, Dara K., Mujahed, Huthayfa, Jonson‐Videsäter, Kerstin, Nore, Beston, Paul, Christer, Lehmann, Sören

“…Summary The small molecule APR‐246 (PRIMA‐1MET) is a novel drug that restores the activity of mutated and unfolded TP53 protein. However, the mechanisms of…”
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Acute Myelogenous Leukemia Cells Secrete Factors that Stimulate Cellular LDL Uptake via Autocrine and Paracrine Mechanisms by Bhuiyan, Hasanuzzaman, Masquelier, Michèle, Tatidis, Loukas, Gruber, Astrid, Paul, Christer, Vitols, Sigurd

“…Leukemic cells isolated from most patients with acute myelogenous leukemia (AML) have higher low density lipoprotein (LDL) uptake than normal mononuclear blood…”
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APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells by Ali, Dina, Jönsson-Videsäter, Kerstin, Deneberg, Stefan, Bengtzén, Sofia, Nahi, Hareth, Paul, Christer, Lehmann, Sören

“…Background:  APR‐246 belongs to a new generation of the compounds that restore normal p53 function in cells with mutated or wild type p53. The purpose of this…”
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Abstract 1170: Correlation between cytidine deaminase single nucleotide polymorphisms and in vitro drug sensitivity, DNA methylation and outcome in normal karyotype acute myelogenous leukemia by Jakobsen Falk, Ingrid, Fyrberg, Anna, Hermanson, Monica, Höglund, Martin, Nahi, Hareth, Palmqvist, Lars, Paul, Christer, Paul, Esbjörn, Rosenquist, Richard, Stockelberg, Dick, Wei, Yuan, Green, Henrik, Lotfi, Kourosh

“…Abstract Background: De novo AML with normal karyotype (NK-AML) comprise a large group of patients without common cytogenetic alterations but with a large…”
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Correlation between cytidine deaminase single nucleotide polymorphisms and in vitro drug sensitivity, DNA methylation and outcome in normal karyotype acute myelogenous leukemia by Falk, Ingrid Jakobsen, Fyrberg, Anna, Hermanson, Monica, Höglund, Martin, Nahi, Hareth, Palmqvist, Lars, Paul, Christer, Paul, Esbjorn, Rosenquist, Richard, Stockelberg, Dick, Wei, Yuan, Green, Henrik, Lotfi, Kourosh

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Time and Dose Dependent Synergism Between Conventional Cytostatics and the p53-Modulating Small Molecule PRIMA-Meth in p53 Mutated Leukemic Cells by Ali, Dina, Paul, Christer, Lehmann, S.ören

“…Background: P53 deletions and mutations can be found in 5 to 15% of patients with acute myeloid leukemia and in about 50% of all human cancers. Mutations in…”
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Abstract 2757: NT5C2 single nucleotide polymorphisms affects survival and response in de novo AML patients with normal karyotype by Fyrberg, Anna, Lofti, Kourosh, Paul, Esbjorn, Paul, Christer, Nahi, Hareth, Gréen, Henrik

“…Abstract The nucleoside analog cytosine arabinoside (Cytosar®, AraC) is one of the corner stones in the treatment of acute myeloid leukemia (AML). Activated…”
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Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia by Nahi, Hareth, Lehmann, Sören, Bengtzen, Sofia, Jansson, Monika, Möllgård, Lars, Paul, Christer, Merup, Mats

“…Chromosomal aberrations are important prognostic parameters in acute myeloid leukemia (AML). Indicators of poor prognosis include del(5q) −5, del(7q) −7,…”
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Intracellular uptake and cytotoxic effect in vitro of doxorubicin and epirubicin in human leukemic and normal hematopoietic cells by TIDEFELT, U, SUNDMAN-ENGBERG, B, PAUL, C

“…Leukemic cells from patients presenting with acute nonlymphoblastic leukemia and normal hematopoietic bone marrow cells from healthy donors for allogeneic bone…”
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In Vitro and Ex Vivo Studies On Cell Lines and Primary Human Leukemia Cells of the Effects of APR-246 Alone and in Combination with Conventional Chemotherapeutic Drugs by Jonsson-Videsater, Kerstin, Ali, Dina, Nahi, Hareth, Bengtzen, Sofia, Deneberg, Stefan, Paul, Christer, Lehmann, Soren

“…Abstract 2751 Poster Board II-727 Mutations of TP53 are associated with an extremely poor prognosis in hematopoietic malignancies and is found in 10 to 15% of…”
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Inverse relationship between leukaemic cell burden and plasma concentrations of daunorubicin in patients with acute myeloid leukaemia by Bogason, Alex, Quartino, Angelica L., Lafolie, Pierre, Masquelier, Michèle, Karlsson, Mats O., Paul, Christer, Gruber, Astrid, Vitols, Sigurd

“…WHAT IS ALREADY KNOWN ABOUT THE SUBJECT • In vitro studies show that daunorubicin (DNR) cytotoxicity decreases with increasing cell density because of a high…”
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Inverse relationship between leukaemic cell burden and plasma concentrations of daunorubicin in patients with acute myeloidleukaemia by Bogason, Alex, Quartino, Angelica L., Lafolie, Pierre, Masquelier, Michèle, Karlsson, Mats O., Paul, Christer, Gruber, Astrid, Vitols, Sigurd

“…center dot In vitro studies show that daunorubicin (DNR) cytotoxicity decreases with increasing cell density because of a high cellular uptake and depletion of…”
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APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells: APR-246 in acute myeloid leukemia by Ali, Dina, Jönsson-Videsäter, Kerstin, Deneberg, Stefan, Bengtzén, Sofia, Nahi, Hareth, Paul, Christer, Lehmann, Sören

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Implications On Drug Resistance and Survival of ABCB1 Single Nucleotide Polymorphisms in Normal Karyotype De Novo AML by Paul, Christer, Green, Henrik, Falk, Ingrid Jakobsen, Lotfi, Kourosh, Paul, Esbjorn, Hermansson, Monika, Rosenquist, Richard, Jonsson-Videsater, Kerstin, Nahi, Hareth

“…Abstract 2648 Poster Board II-624 Multidrug resistance and expression of the ATP-dependent drug transporting protein ABCB1 is a clinically relevant problem in…”
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BCRP mRNA expression v. clinical outcome in 40 adult AML patients by Uggla, Bertil, Ståhl, Elisabet, Wågsäter, Dick, Paul, Christer, Karlsson, Mats G., Sirsjö, Allan, Tidefelt, Ulf

“…Efflux pumps are considered being mechanisms behind drug resistance in acute myeloid leukaemia (AML). A recently described efflux pump, breast cancer…”
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Low Expression of p14ARF in De Novo AML with Normal Karyotype Is Associated with Short Survival but Increased in Vitro Sensitivity to p53 Modulating Drugs by Paul, Esbjörn, Uggla, Bertil, Wiman, Kals G, Paul, Christer, Lehmann, Soren, Nahi, Hareth

“…Background: The p53 protein is strongly regulated by the E3 ligase HDM-2, which specifically binds to p53 and causes proteosomal degradation. The p14ARF…”
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