Search Results - "PAU, B"

The mitochondrial ATP synthase is a shared drug target for aging and dementia by Goldberg, Joshua, Currais, Antonio, Prior, Marguerite, Fischer, Wolfgang, Chiruta, Chandramouli, Ratliff, Eric, Daugherty, Daniel, Dargusch, Richard, Finley, Kim, Esparza‐Moltó, Pau B., Cuezva, José M., Maher, Pamela, Petrascheck, Michael, Schubert, David

“…Summary Aging is a major driving force underlying dementia, such as that caused by Alzheimer's disease (AD). While the idea of targeting aging as a therapeutic…”
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Manipulating mitochondrial electron flow enhances tumor immunogenicity by Mangalhara, Kailash Chandra, Varanasi, Siva Karthik, Johnson, Melissa A, Burns, Mannix J, Rojas, Gladys R, Esparza Moltó, Pau B, Sainz, Alva G, Tadepalle, Nimesha, Abbott, Keene L, Mendiratta, Gaurav, Chen, Dan, Farsakoglu, Yagmur, Kunchok, Tenzin, Hoffmann, Filipe Araujo, Parisi, Bianca, Rincon, Mercedes, Vander Heiden, Matthew G, Bosenberg, Marcus, Hargreaves, Diana C, Kaech, Susan M, Shadel, Gerald S

“…Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the…”
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The Role of Mitochondrial H + -ATP Synthase in Cancer by Esparza-Moltó, Pau B, Cuezva, José M

“…Cancer cells reprogram energy metabolism by boosting aerobic glycolysis as a main pathway for the provision of metabolic energy and of precursors for anabolic…”
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Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition by Esparza-Moltó, Pau B, Romero-Carramiñana, Inés, Núñez de Arenas, Cristina, Pereira, Marta P, Blanco, Noelia, Pardo, Beatriz, Bates, Georgina R, Sánchez-Castillo, Carla, Artuch, Rafael, Murphy, Michael P, Esteban, José A, Cuezva, José M

“…The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the…”
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Regulation of the H+-ATP synthase by IF1: a role in mitohormesis by Esparza-Moltó, Pau B., Nuevo-Tapioles, Cristina, Cuezva, José M.

“…The mitochondrial H + -ATP synthase is a primary hub of cellular homeostasis by providing the energy required to sustain cellular activity and regulating the…”
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IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype by Domínguez-Zorita, Sonia, Romero-Carramiñana, Inés, Santacatterina, Fulvio, Esparza-Moltó, Pau B., Simó, Carolina, del-Arco, Araceli, Núñez de Arenas, Cristina, Saiz, Jorge, Barbas, Coral, Cuezva, José M.

“…ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP synthase. The expression of IF1 in differentiated human and mouse cells is highly…”
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Tissue‐specific expression and post‐transcriptional regulation of the ATPase inhibitory factor 1 (IF1) in human and mouse tissues by Esparza-Moltó, Pau B., Nuevo-Taρioles, Cristina, Chamorro, Margarita, Nájera, Laura, Torresano, Laura, Santacatterina, Fulvio, Cuezva, José M.

“…ABSTRACT The ATPase inhibitory factor 1 (IF1) is an intrinsically disordered protein that regulates the activity of the mitochondrial ATP synthase…”
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The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function by Domínguez-Zorita, Sonia, Romero-Carramiñana, Inés, Cuezva, José M, Esparza-Moltó, Pau B

“…The ATP synthase is an essential multifunctional enzyme complex of mitochondria that produces most of cellular ATP, shapes the structure of the inner membrane…”
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Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival by Romero-Carramiñana, Inés, Dominguez-Zorita, Sonia, Esparza-Moltó, Pau B., Cuezva, José M.

“…T cells experience metabolic reprogramming to an enhanced glycolysis upon activation. Herein, we have investigated whether ATPase Inhibitory Factor 1 (IF1),…”
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IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential by Romero-Carramiñana, Inés, Esparza-Moltó, Pau B., Domínguez-Zorita, Sonia, Nuevo-Tapioles, Cristina, Cuezva, José M.

“…The coexistence of two pools of ATP synthase in mitochondria has been largely neglected despite in vitro indications for the existence of reversible…”
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Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy by Torresano, Laura, Santacatterina, Fulvio, Domínguez-Zorita, Sonia, Nuevo-Tapioles, Cristina, Núñez-Salgado, Alfonso, Esparza-Moltó, Pau B., González-Llorente, Lucía, Romero-Carramiñana, Inés, Núñez de Arenas, Cristina, Sánchez-Garrido, Brenda, Nájera, Laura, Salas, Clara, Provencio, Mariano, Cuezva, José M.

“…Lung cancer is the leading cause of cancer-related death worldwide despite the success of therapies targeting oncogenic drivers and immune-checkpoint…”
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Different mitochondrial genetic defects exhibit the same protein signature of metabolism in skeletal muscle of PEO and MELAS patients: A role for oxidative stress by Santacatterina, Fulvio, Torresano, Laura, Núñez-Salgado, Alfonso, Esparza-Molto, Pau B., Olive, Montse, Gallardo, Eduard, García-Arumi, Elena, Blazquez, Alberto, González-Quintana, Adrián, Martín, Miguel A., Cuezva, José M.

“…A major challenge in mitochondrial diseases (MDs) is the identification of biomarkers that could inform of the mechanisms involved in the phenotypic expression…”
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ATPase Inhibitory Factor 1 (IF1): A main driver of metabolic reprogramming and nuclear signaling in cancer by Cuezva, José M., Formentini, Laura, Santacatterina, Fulvio, Soldevilla, Beatriz, Nuevo-Tapioles, Cristina, Esparza, Pau B., González, Lucía

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Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice by Santo, J, Lopez-Herrera, C, Apolit, C, Bareche, Y, Lapasset, L, Chavey, C, Capozi, S, Mahuteau-Betzer, F, Najman, R, Fornarelli, P, Lopez-Mejía, I C, Béranger, G, Casas, F, Amri, E-Z, Pau, B, Scherrer, D, Tazi, J

“…Bakground/Objectives: Intense drug discovery efforts in the metabolic field highlight the need for novel strategies for the treatment of obesity. Alternative…”
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Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat by Broca, Christophe, Breil, Vincent, Cruciani-Guglielmacci, Céline, Manteghetti, Michèle, Rouault, Christine, Derouet, Michel, Rizkalla, Salwa, Pau, Bernard, Petit, Pierre, Ribes, Gérard, Ktorza, Alain, Gross, René, Reach, Gérard, Taouis, Mohammed

“…ID-1101 (4-hydroxyisoleucine), an amino acid extracted from fenugreek seeds, exhibits an interesting glucose-dependent insulin-stimulating activity. The…”
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Release of muscle proteins after downhill running in male and female subjects by Sorichter, S., Mair, J., Koller, A., Calzolari, C., Huonker, M., Pau, B., Puschendorf, B.

“…The release of muscle proteins after downhill running, which mainly includes eccentric muscle action, was compared in females (F; n=9) and males (M; n=9). They…”
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Cardiac-specific immunoenzymometric assay of troponin I in the early phase of acute myocardial infarction by Larue, C, Calzolari, C, Bertinchant, J P, Leclercq, F, Grolleau, R, Pau, B

“…The screening by immunoenzymometric assay (IEMA) of 784 monoclonal antibody (MAb) combinations resulted in the selection of an optimal pair of MAbs for…”
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A peptide mimetic of an anti-CD4 monoclonal antibody by rational design by Casset, Florence, Roux, Florence, Mouchet, Patrick, Bes, Cedric, Chardes, Thierry, Granier, Claude, Mani, Jean-Claude, Pugnière, Martine, Laune, Daniel, Pau, Bernard, Kaczorek, Michel, Lahana, Roger, Rees, Anthony

“…The development of rational methods to design ‘continuous’ sequence mimetics of discontinuous regions of protein sequence has, to now, been only marginally…”
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Tau and apo E in CSF: potential aid for discriminating Alzheimerʼs disease from other dementias by Molina, L, Touchon, J, Herpé, M, Lefranc, D, Duplan, L, Cristol, J P, Sabatier, R, Vermersch, P, Pau, B, Mourton-Gilles, C

“…To evaluate the usefulness of tau proteins as biological markers in the diagnosis of dementia of the Alzheimer type (DAT), we analyzed the concentration of tau…”
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Regulation of the H^sup +^-ATP synthase by IF1: a role in mitohormesis by Esparza-moltó, Pau B, Nuevo-tapioles, Cristina, Cuezva, José M

“…The mitochondrial H+-ATP synthase is a primary hub of cellular homeostasis by providing the energy required to sustain cellular activity and regulating the…”
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