Search Results - "PATTISON, Christine"

Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects by Dymond, Angela W., MSc, Howes, Colin, PhD, Pattison, Christine, MChem (Hons), So, Karen, MD, Mariani, Gabriella, MD, Savage, Mark, BSc, Mair, Stuart, MBChB, Ford, Gill, BSc, Martin, Paul, PhD

“…Abstract Purpose Selumetinib (AZD6244, ARRY-142886), an oral mitogen activated kinase 1/2 inhibitor, is in clinical development for the treatment of a variety…”
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Utility of Long-Term Cultured Human Hepatocytes as an in Vitro Model for Cytochrome P450 Induction by MENESES-LORENTE, Georgina, PATTISON, Christine, GUYOMARD, Claire, CHESNE, Christophe, HEAVENS, Robert, WATT, Alan P, SOHAL, Bindi

“…Cytochrome P450 (P450) induction may have considerable implications for drug therapy. Therefore, understanding the induction potential of a new chemical entity…”
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In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology by SCHULZ-UTERMOEHL, Timothy, SPEAR, Michael, POLLARD, Christopher R. J, PATTISON, Christine, ROLLISON, Helen, SARDA, Sunil, WARD, Michelle, BUSHBY, Nick, JORDAN, Angela, HARRISON, Mike

“…The in vitro metabolism of cediranib (4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline), a vascular endothelial…”
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3,4-Fused cyclohexyl sulfones as γ-secretase inhibitors by Shaw, Duncan, Best, Jonathan, Dinnell, Kevin, Nadin, Alan, Shearman, Mark, Pattison, Christine, Peachey, James, Reilly, Michael, Williams, Brian, Wrigley, Jonathan, Harrison, Timothy

“…The identification of a potent γ-secretase inhibitor, for example (ED 50 = 0.06 nM), is reported. The 3,4-fused sulfamides, sulfonamides and sulfone have been…”
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In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat by Best, Jonathan D, Jay, Mark T, Otu, Franklin, Churcher, Ian, Reilly, Michael, Morentin-Gutierrez, Pablo, Pattison, Christine, Harrison, Tim, Shearman, Mark S, Atack, John R

“…Plaques in the parenchyma of the brain containing Abeta peptides are one of the hallmarks of Alzheimer's disease. These Abeta peptides are produced by the…”
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Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide] by Best, Jonathan D, Jay, Mark T, Otu, Franklin, Ma, Jerome, Nadin, Alan, Ellis, Semantha, Lewis, Huw D, Pattison, Christine, Reilly, Michael, Harrison, Timothy, Shearman, Mark S, Williamson, Toni L, Atack, John R

“…The efficacy of gamma-secretase inhibitors in vivo has, to date, been generally assessed in transgenic mouse models expressing increased levels of amyloid-beta…”
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Increased intraoperative cardiovascular morbidity in diabetics with autonomic neuropathy by Burgos, L G, Ebert, T J, Asiddao, C, Turner, L A, Pattison, C Z, Wang-Cheng, R, Kampine, J P

“…Thirty-eight consenting subjects scheduled for elective ophthalmologic surgery were classified as nondiabetics (n = 21) or diabetics (n = 17) and were tested…”
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Transesophageal atrial pacing for intraoperative sinus bradycardia or AV junctional rhythm: feasibility as prophylaxis in 200 anesthetized adults and hemodynamic effects of treatment by Atlee, 3rd, J L, Pattison, C Z, Mathews, E L, Hedman, A G

“…Sinus bradycardia (SB) or atrioventricular junctional rhythm (AVJR) may produce circulatory insufficiency in anesthetized surgical patients, especially those…”
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Evaluation of transesophageal atrial pacing stethoscope in adult surgical patients under general anesthesia by Atlee, 3rd, J L, Pattison, C Z, Mathews, E L, Bilof, R M, Hedman, A G

“…Sinus bradycardia (SB) and atrioventricular junctional rhythm (AVJR) commonly cause circulatory insufficiency in anesthetized surgical patients. Treatment is…”
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Atrial pacing thresholds measured in anesthetized patients with the use of an esophageal stethoscope modified for pacing by PATTISON, C. Z, ATLEE, J. L, MATHEWS, E. L, BULJUBASIC, N, ENTRESS, J. J

“…Transesophageal atrial pacing (TAP) with the use of standard, thermistor-equipped, esophageal stethoscopes, modified for pacing by incorporation of a 4-French,…”
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Transesophageal indirect atrial pacing for drug-resistant sinus bradycardia by PATTISON, C. Z, ATLEE, J. L, KREBS, L. H, MADIREDDI, L, KETTLER, R. E

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Halothane anesthesia attenuates cardiopulmonary baroreflex control of peripheral resistance in humans by EBERT, T. J, KOTRLY, K. J, VUCINS, E. J, PATTISON, C. Z, KAMPINE, J. P

“…The effects of halothane anesthesia on cardiopulmonary (low pressure) baroreflex control of peripheral resistance were studied in 10 ASA class I young men…”
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Pulmonary artery rupture during cardiopulmonary bypass by Dhamee, M S, Pattison, C Z

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