Search Results - "PATRONO, C."

Coxibs, Traditional NSAIDs, and Cardiovascular Safety Post‐PRECISION: What We Thought We Knew Then and What We Think We Know Now by Patrono, C, Baigent, C

“…The aim of the present review is to analyze how thinking about the cardiovascular safety of nonsteroidal antiinflammatory drugs has evolved during the past two…”
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Aspirin, 110 years later by PATRONO, C., ROCCA, B.

“…Although conceived at the end of the 19th century as a synthetic analgesic agent with improved gastric tolerability vs. naturally occurring salicylates,…”
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Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials by BAIGENT, Colin

“…Summary Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs)…”
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In Silico Modeling of the Antiplatelet Pharmacodynamics of Low‐dose Aspirin in Health and Disease by Giaretta, A, Rocca, B, Di Camillo, B, Toffolo, GM, Patrono, C

“…The influence of platelet turnover on cyclooxygenase (COX‐1) inhibition by low‐dose aspirin remains largely uncharacterized due to limited feasibility of…”
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Aspirin resistance: definition, mechanisms and clinical read-outs by Patrono, C

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Reappraisal of the clinical pharmacology of low‐dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action by Patrignani, P., Tacconelli, S., Piazuelo, E., Di Francesco, L., Dovizio, M., Sostres, C., Marcantoni, E., Guillem‐Llobat, P., Del Boccio, P., Zucchelli, M., Patrono, C., Lanas, A.

“…Summary Background Even though the acetylation of platelet cyclooxygenase (COX)‐1 at serine‐529 is the direct mechanism of action of low‐dose aspirin, its…”
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Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues by Thun, Michael J., Henley, S. Jane, Patrono, Carlo

“…Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective…”
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The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low‐dose aspirin in patients with and without diabetes by ROCCA, B., SANTILLI, F., PITOCCO, D., MUCCI, L., PETRUCCI, G., VITACOLONNA, E., LATTANZIO, S., MATTOSCIO, D., ZACCARDI, F., LIANI, R., VAZZANA, N., DEL PONTE, A., FERRANTE, E., MARTINI, F., CARDILLO, C., MOROSETTI, R., MIRABELLA, M., GHIRLANDA, G., DAVÌ, G., PATRONO, C.

“…See also Lordkipanidze M, Harrison P. Aspirin twice a day keeps new COX‐1 at bay. This issue, pp 1217–9. Summary  Background.  Interindividual variability in…”
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On‐pump Cardiac Surgery Enhances Platelet Renewal and Impairs Aspirin Pharmacodynamics: Effects of Improved Dosing Regimens by Cavalca, V, Rocca, B, Veglia, F, Petrucci, G, Porro, B, Myasoedova, V, Cristofaro, R, Turnu, L, Bonomi, A, Songia, P, Cavallotti, L, Zanobini, M, Camera, M, Alamanni, F, Parolari, A, Patrono, C, Tremoli, E

“…On‐pump cardiac surgery may trigger inflammation and accelerate platelet cyclooxygenase‐1 renewal, thereby modifying low‐dose aspirin pharmacodynamics…”
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A NOVEL BIOLOGICAL DOSIMETRY ASSAY AS A POTENTIAL TOOL FOR TRIAGE DOSE ASSESSMENT IN CASE OF LARGE-SCALE RADIOLOGICAL EMERGENCY by Testa, A, Palma, V, Patrono, C

“…Abstract In case of mass radiological emergencies, new strategies involving biological and clinical endpoints are requested for an efficient triage…”
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Determinants of the interindividual variability in response to antiplatelet drugs by ROCCA, B., PATRONO, C.

“…The aim of this review article is to discuss the main determinants of the interindividual variability in response to antiplatelet agents. The main sources of…”
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Low‐Dose Aspirin Acetylates Cyclooxygenase‐1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer by Patrignani, P, Sacco, A, Sostres, C, Bruno, A, Dovizio, M, Piazuelo, E, Di Francesco, L, Contursi, A, Zucchelli, M, Schiavone, S, Tacconelli, S, Patrono, C, Lanas, A

“…The mechanism of action of low‐dose aspirin in the prevention of colorectal cancer (CRC) remains largely hypothetical. We aimed to compare the effects of…”
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The Coxibs, Selective Inhibitors of Cyclooxygenase-2 by FitzGerald, Garret A, Patrono, Carlo

“…Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual pain, and headache. Although they are effective, their long-term use…”
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RENEB Inter-Laboratory Comparison 2021: The Cytokinesis-Block Micronucleus Assay by Vral, A., Endesfelder, D., Balázs, J., Beinke, C., Cuceu Petrenci, C., Finot, F., Garty, G., Hadjiiska, L., Hristova, R., Ivanova, I., Lee, Y., Lumniczky, K., Milanova, M., Monteiro Gil, O., Oestreicher, U., Pajic, J., Patrono, C., Pham, N.D., Perletti, G., Seong, K.M., Sommer, S., Szatmári, T., Testa, A., Tichy, A., Tran, T.M., Wilkins, R., Port, M., Abend, M., Baeyens, A.

“…The goal of the RENEB inter-laboratory comparison 2021 exercise was to simulate a large-scale radiation accident involving a network of biodosimetry labs. Labs…”
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Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus by SANTILLI, F., FORMOSO, G., SBRACCIA, P., AVERNA, M., MICCOLI, R., DI FULVIO, P., GANCI, A., PULIZZI, N., LATTANZIO, S., CIABATTONI, G., CONSOLI, A., LAURO, R., PATRONO, C., DAVÌ, G.

“…Background: Chronic hyperglycemia is a major contributor to in vivo platelet activation in diabetes mellitus. Objectives: To evaluate the effects of acarbose,…”
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Aspirin as an Antiplatelet Drug by Patrono, Carlo

“…The past 10 years have witnessed major changes in our understanding of the pathophysiologic mechanisms underlying vascular occlusion 1 , 2 and considerable…”
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An in silico model of aspirin-iduced inactivation of platelet and Megakaryocyte Cyclooxygenase-1 by Giaretta, A, Rocca, B, Di Camillo, B, Toffolo, G.M, Patrono, C

“…[...]the model explains an increased COX-1 acetylation following a shorter dosing interval (100 mg twice daily) as compared to a higher (200 mg) once-daily…”
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An in silico model of aspirin-iduced inactivation of platelet and Megakaryocyte Cyclooxygenase-1 by Giaretta, A, Rocca, B, Di Camillo, B, Toffolo, G.M, Patrono, C

“…[...]the model explains an increased COX-1 acetylation following a shorter dosing interval (100 mg twice daily) as compared to a higher (200 mg) once-daily…”
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ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD by Ryden, L., Grant, P. J., Anker, S. D., Berne, C., Cosentino, F., Danchin, N., Deaton, C., Escaned, J., Hammes, H.-P., Huikuri, H., Marre, M., Marx, N., Mellbin, L., Ostergren, J., Patrono, C., Seferovic, P., Uva, M. S., Taskinen, M.-R., Tendera, M., Tuomilehto, J., Valensi, P., Zamorano, J. L.

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Silver syndrome variant of hereditary spastic paraplegia : A locus to 4p and allelism with SPG4 by ORLACCHIO, A, PATRONO, C, GAUDIELLO, F, ROCCHI, C, MOSCHELLA, V, FLORIS, R, BERNARDI, G, KAWARAI, T

“…To perform a clinical and genetic study of two large Italian families (RM-36 and RM-51) showing the cardinal clinical features of Silver syndrome (SS), a rare…”
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