Search Results - "PATLEWICZ, Grace Y"

A chemical dataset for evaluation of alternative approaches to skin-sensitization testing by Gerberick, G. Frank, Ryan, Cindy A., Kern, Petra S., Dearman, Rebecca J., Kimber, Ian, Patlewicz, Grace Y., Basketter, David A.

“…Allergic contact dermatitis resulting from skin sensitization is a common occupational and environmental health problem. In recent years, the local lymph node…”
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Further evaluation of quantitative structure-activity relationship models for the prediction of the skin sensitization potency of selected fragrance allergens by Patlewicz, Grace Y., Basketter, David A., Smith Pease, Camilla K., Wilson, Karen, Wright, Zoe M., Roberts, David W., Bernard, Guillaume, Arnau, Elena Giménez, Lepoittevin, Jean-Pierre

“…Fragrance substances represent a very diverse group of chemicals; a proportion of them are associated with the ability to cause allergic reactions in the skin…”
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The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements? by Kimber, Ian, Dearman, Rebecca J., Betts, Catherine J., Gerberick, G. Frank, Ryan, Cindy A., Kern, Petra S., Patlewicz, Grace Y., Basketter, David A.

“…The local lymph node assay (LLNA), an alternative approach to skin‐sensitizing testing, has made a significant contribution to animal welfare by permitting a…”
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Integrated testing and assessment approaches for skin sensitization: a commentary by Roberts, David W., Patlewicz, Grace Y.

“…ABSTRACT A Bayesian integrated testing strategy (ITS) approach, aiming to assess skin sensitization potency, has been presented, in which data from various…”
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Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships by Netzeva, T.I, Worth, A.P, Aldenberg, T, Benigni, R, Cronin, M.T.D, Gramatica, P, Jaworska, J.S, Kahn, S, Klopman, G, Marchant, C.A

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Current status of methods for defining the applicability domain of (Quantitative) structure-activity relationships : The report and recommendations of ECVAM workshop 52 by NETZEVA, Tatiana I, WORTH, Andrew P, MYATT, Glenn, NIKOLOVA-JELIAZKOVA, Nina, PATLEWICZ, Grace Y, PERKINS, Roger, ROBERTS, David W, SCHULTZ, Terry W, STANTON, David T, VAN DE SANDT, Johannes J. M, TONG, Weida, VEITH, Gilman, ALDENBERG, Tom, YANG, Chihae, BENIGNI, Romualdo, CRONIN, Mark T. D, GRAMATICA, Paola, JAWORSKA, Joanna S, KAHN, Scott, KLOPMAN, Gilles, MARCHANT, Carol A

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Updating the Skin Sensitization in Vitro Data Assessment Paradigm in 2009 - a chemistry and QSAR perspective by Roberts, David W., Patlewicz, Grace Y.

“…This communication is stimulated by a recent Toxicology Update by Basketter and Kimber (2009), updating an earlier paradigm (Jowsey et al., 2006) for…”
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Structure-activity relationships for skin sensitization: recent improvements to Derek for Windows by Langton, Kate, Patlewicz, Grace Y., Long, Anthony, Marchant, Carol A., Basketter, David A.

“…Derek for Windows (DfW) is a knowledge‐based expert system that predicts the toxicity of a chemical from its structure. Its predictions are based in part on…”
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Nonanimal Alternatives for Skin Sensitization: Letter to the Editor by Roberts, David W., Patlewicz, Grace Y.

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Skin Sensitization: Modeling Based on Skin Metabolism Simulation and Formation of Protein Conjugates by Dimitrov, Sabcho D., Low, Lawrence K., Patlewicz, Grace Y., Kern, Petra S., Dimitrova, Gergana D., Comber, Mike H. I., Phillips, Richard D., Niemela, Jay, Bailey, Paul T., Mekenyan, Ovanes G.

“…A quantitative structure-activity relationship (QSAR) system for estimating skin sensitization potency has been developed that incorporates skin metabolism and…”
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The reduced local lymph node assay: the impact of group size by Ryan, Cindy A., Chaney, Joel G., Kern, Petra S., Patlewicz, Grace Y., Basketter, David A., Betts, Catherine J., Dearman, Rebecca J., Kimber, Ian, Gerberick, G. Frank

“…The local lymph node assay (LLNA) is a skin sensitization test that provides animal welfare benefits. To reduce animal usage further, a modified version…”
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Investigation of the skin sensitizing activity of linalool by Basketter, David A., Wright, Zoë M., Colson, Neil R., Patlewicz, Grace Y., Pease, Camilla K. Smith

“…An increasing range of chemicals appears to be capable of causing skin sensitization as a result of their capacity to undergo air oxidation (autoxidation) with…”
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Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods by Gerberick, G Frank, Ryan, Cindy A, Kern, Petra S, Schlatter, Harald, Dearman, Rebecca J, Kimber, Ian, Patlewicz, Grace Y, Basketter, David A

“…Within the toxicology community, considerable effort is directed toward the development of alternative methods for skin sensitization testing. The availability…”
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A step change towards risk assessment in the 21st century by Patlewicz, Grace Yvonne, Lander, Deborah Rosemary

“…Chemical Regulation and the means by which data is generated for the purposes of risk assessment is undergoing a tremendous shift. There is a strong impetus in…”
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Contact allergy: the role of skin chemistry and metabolism by Smith Pease, C. K., Basketter, D. A., Patlewicz, G. Y.

“…Summary Chemical reactivity plays the driving role in the biological processes that result in the induction of allergic contact dermatitis. This paper presents…”
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