Search Results - "PATHIL, Anita"

Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study1 by Krawczyk, Marcin, Rau, Monika, Schattenberg, Jörn M., Bantel, Heike, Pathil, Anita, Demir, Münevver, Kluwe, Johannes, Boettler, Tobias, Lammert, Frank, Geier, Andreas

“…The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for nonalcoholic fatty liver disease (NAFLD). Here we…”
Get full text

Circulating Phospholipid Patterns in NAFLD Patients Associated with a Combination of Metabolic Risk Factors by Tiwari-Heckler, Shilpa, Gan-Schreier, Hongying, Stremmel, Wolfgang, Chamulitrat, Walee, Pathil, Anita

“…Non-alcoholic fatty liver disease (NAFLD) is associated with inefficient macro- and micronutrient metabolism, and alteration of circulating phospholipid…”
Get full text

Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma by Goeppert, Benjamin, Roessler, Stephanie, Renner, Marcus, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil, Anita, Czink, Elena, Köhler, Bruno, Springfeld, Christoph, Pfeiffenberger, Jan, Rupp, Christian, Weiss, Karl Heinz, Schirmacher, Peter, von Knebel Doeberitz, Magnus, Kloor, Matthias

“…Background A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is…”
Get full text

Ledipasvir plus sofosbuvir fixed-dose combination for 6 weeks in patients with acute hepatitis C virus genotype 1 monoinfection (HepNet Acute HCV IV): an open-label, single-arm, phase 2 study by Deterding, Katja, MD, Spinner, Christoph D, MD, Schott, Eckart, Prof, Welzel, Tania M, MD, Gerken, Guido, Prof, Klinker, Hartwig, Prof, Spengler, Ulrich, Prof, Wiegand, Johannes, MD, zur Wiesch, Julian Schulze, MD, Pathil, Anita, MD, Cornberg, Markus, Prof, Umgelter, Andreas, MD, Zöllner, Caroline, MD, Zeuzem, Stefan, Prof, Papkalla, Armin, PhD, Weber, Kristina, PhD, Hardtke, Svenja, PhD, von der Leyen, Heiko, Prof, Koch, Armin, Prof, von Witzendorff, Dorothee, PhD, Manns, Michael P, Prof, Wedemeyer, Heiner, Prof

“…Summary Background Early treatment of acute hepatitis C virus (HCV) infection with interferon alfa is highly effective, but can be associated with frequent…”
Get full text

miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR‐451a/ATF2 axis by Loeffler, Moritz A, Hu, Jun, Kirchner, Martina, Wei, Xiyang, Xiao, Yi, Albrecht, Thomas, De La Torre, Carolina, Sticht, Carsten, Banales, Jesus M, Vogel, Monika N, Pathil‐Warth, Anita, Mehrabi, Arianeb, Hoffmann, Katrin, Rupp, Christian, Köhler, Bruno, Springfeld, Christoph, Schirmacher, Peter, Ji, Junfang, Roessler, Stephanie, Goeppert, Benjamin

“…Distal cholangiocarcinoma (dCCA) is a biliary tract cancer with a dismal prognosis and is often preceded by biliary intraepithelial neoplasia (BilIN),…”
Get full text

Anti-inflammatory properties of ursodeoxycholyl lysophosphatidylethanolamide in endotoxin-mediated inflammatory liver injury by Ludwig, Johannes Maximilian, Zhang, Yuling, Chamulitrat, Walee, Stremmel, Wolfgang, Pathil, Anita

“…Endotoxin-mediated liver inflammation is a key component of many acute and chronic liver diseases contributing to liver damage, fibrosis and eventually organ…”
Get full text

Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma - correlation with clinicopathological data and comparison of antibodies by Kriegsmann, Mark, Roessler, Stephanie, Kriegsmann, Katharina, Renner, Marcus, Longuespée, Rémi, Albrecht, Thomas, Loeffler, Moritz, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil, Anita, Köhler, Bruno, Springfeld, Christoph, Rupp, Christian, Weiss, Karl Heinz, Goeppert, Benjamin

“…Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there…”
Get full text

Bivalent Ligand UDCA-LPE Inhibits Pro-Fibrogenic Integrin Signalling by Inducing Lipid Raft-Mediated Internalization by Su, Jie, Gan-Schreier, Hongying, Goeppert, Benjamin, Chamulitrat, Walee, Stremmel, Wolfgang, Pathil, Anita

“…Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) is a synthetic bile acid-phospholipid conjugate with profound hepatoprotective and anti-fibrogenic…”
Get full text

Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers by Krawczyk, Marcin, Bantel, Heike, Rau, Monika, Schattenberg, Jörn M, Grünhage, Frank, Pathil, Anita, Demir, Münevver, Kluwe, Johannes, Boettler, Tobias, Weber, Susanne N, Geier, Andreas, Lammert, Frank

“…Non-alcoholic fatty liver disease (NAFLD) is frequent among obese individuals with metabolic syndrome. Variants PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7…”
Get full text

Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma by Goeppert, Benjamin, Renner, Marcus, Singer, Stephan, Albrecht, Thomas, Zhang, Qiangnu, Mehrabi, Arianeb, Pathil, Anita, Springfeld, Christoph, Köhler, Bruno, Rupp, Christian, Weiss, Karl Heinz, Kühl, Anja A., Arsenic, Ruza, Pape, Ulrich Frank, Vogel, Arndt, Schirmacher, Peter, Roessler, Stephanie, Utku, Nalân

“…Carboxylesterase 2 (CES2) is instrumental for conversion of ester-containing prodrugs in cancer treatment. Novel treatment strategies are exceedingly needed…”
Get full text

Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate by ARMEANU, Sorin, BITZER, Michael, STEINLE, Alexander, SALIH, Helmut R, LAUER, Ulrich M, VENTURELLI, Sascha, PATHIL, Anita, KRUSCH, Matthias, KAISER, Stephan, JOBST, Jurgen, SMIRNOW, Irina, WAGNER, Annika

“…Natural killer (NK) cells as components of the innate immunity substantially contribute to antitumor immune responses. However, the tumor-associated ligands…”
Get full text

Successful direct acting antiviral (DAA) treatment of HCV/HIV-coinfected patients before and after liver transplantation by Grottenthaler, Julia M, Werner, Christoph R, Steurer, Martina, Spengler, Ulrich, Berg, Thomas, Engelmann, Cornelius, Wedemeyer, Heiner, von Hahn, Thomas, Stremmel, Wolfgang, Pathil, Anita, Seybold, Ulrich, Schott, Eckart, Blessin, Usha, Sarrazin, Christoph, Welker, Martin-Walter, Harrer, Ellen, Scholten, Stefan, Hinterleitner, Clemens, Lauer, Ulrich M, Malek, Nisar P, Berg, Christoph P

“…The aim of this multicenter retrospective study was to investigate safety and efficacy of direct acting antiviral (DAA) treatment in the rare subgroup of…”
Get full text

Low frequency of mismatch repair deficiency in gallbladder cancer by Goeppert, Benjamin, Roessler, Stephanie, Renner, Marcus, Loeffler, Moritz, Singer, Stephan, Rausch, Melina, Albrecht, Thomas, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil, Anita, Czink, Elena, Köhler, Bruno, Springfeld, Christoph, Rupp, Christian, Weiss, Karl Heinz, Schirmacher, Peter, von Knebel Doeberitz, Magnus, Kloor, Matthias

“…DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at…”
Get full text

Hepatic sarcoidosis: Clinical characteristics and outcome by Graf, Christiana, Arncken, Jeannette, Lange, Christian M., Willuweit, Katharina, Schattenberg, Jörn M., Seessle, Jessica, Lang-Meli, Julia, Böttler, Tobias, Dietz, Julia, Wetzstein, Nils, Mondorf, Antonia, Vermehren, Johannes, Rohde, Gernot, Zeuzem, Stefan, Pathil, Anita

“…Clinical manifestation of hepatic involvement in sarcoidosis can vary from asymptomatic disease to severe complications such as cirrhosis and portal…”
Get full text

Loss of aquaporin-4 expression and putative function in non-small cell lung cancer by Warth, Arne, Muley, Thomas, Meister, Michael, Herpel, Esther, Pathil, Anita, Hoffmann, Hans, Schnabel, Philipp A, Bender, Christian, Buness, Andreas, Schirmacher, Peter, Kuner, Ruprecht

“…Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel…”
Get full text

Epigenetic combination therapy as a tumor‐selective treatment approach for hepatocellular carcinoma by Venturelli, Sascha, Armeanu, Sorin, Pathil, Anita, Hsieh, Chih‐Jen, Weiss, Thomas S., Vonthein, Reinhard, Wehrmann, Manfred, Gregor, Michael, Lauer, Ulrich M., Bitzer, Michael

“…BACKGROUND. Innovative epigenetic therapeutics comprise histone deacetylase inhibitors (HDAC‐I) and demethylating agents (DA). It was recently found that…”
Get full text

HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis by Albrecht, Thomas, Rausch, Melina, Rössler, Stephanie, Albrecht, Michael, Braun, Jana Dorothea, Geissler, Veronika, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil-Warth, Anita, Mechtersheimer, Gunhild, Renner, Marcus, Rupp, Christian, Weiss, Karl Heinz, Busch, Elena, Köhler, Bruno, Springfeld, Christoph, Schirmacher, Peter, Goeppert, Benjamin

“…Cholangiocarcinoma is a rapidly fatal cancer entity with a median survival of less than one year. In contrast to many other malignancies, no substantial…”
Get full text

Prescription and efficacy of daclatasvir and sofosbuvir ± ribavirin for hepatitis C infection, including patient-reported outcomes, in routine practice in three European countries: The CMPASS-EU cohort study by Bourgeois, Stefan, van Erpecum, Karel, Delwaide, Jean, Naumann, Uwe, Christensen, Stefan, Moreno, Christophe, Pathil, Anita, Schippers, Emile, van Emmerik, Nancy, Caritey, Benoit, Fischer, Conrad, Mercier, Florence, Petersen, Joerg

“…Prescription and efficacy of daclatasvir and sofosbuvir ± ribavirin, including patient-reported outcomes, in routine practice in three European countries: the…”
Get full text

HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma by Albrecht, Thomas, Rausch, Melina, Roessler, Stephanie, Geissler, Veronika, Albrecht, Michael, Halske, Christine, Seifert, Carolin, Renner, Marcus, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil-Warth, Anita, Busch, Elena, Köhler, Bruno, Rupp, Christian, Weiss, Karl Heinz, Springfeld, Christoph, Röcken, Christoph, Schirmacher, Peter, Goeppert, Benjamin

“…Gallbladder carcinoma (GBC) is an aggressive type of cancer with a dismal prognosis. Recent case reports have highlighted the human epidermal growth factor…”
Get full text

DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data by Goeppert, Benjamin, Roessler, Stephanie, Becker, Natalia, Zucknick, Manuela, Vogel, Monika N, Warth, Arne, Pathil‐Warth, Anita, Mehrabi, Arianeb, Schirmacher, Peter, Mollenhauer, Jan, Renner, Marcus

“…Aims Deleted in malignant brain tumours 1 (DMBT1) exerts functions in the regulation of epithelial differentiation and inflammation and has been proposed as a…”
Get full text