Search Results - "PATHARE, P. M"

Development of a Unique Bismuth (Bi-213) Automated Generator for Use in Cancer Therapy by Bray, Lane A, Tingey, Joel M, DesChane, Jaquetta R, Egorov, Oleg B, Tenforde, Thomas S, Wilbur, D. Scott, Hamlin, Don K, Pathare, P. M

“…A unique separations chemistry and an automated “generator” have been developed for application of the α-emitting radionuclide 213Bi to cancer therapy. The…”
Get full text

Biotin Reagents for Antibody Pretargeting. 5. Additional Studies of Biotin Conjugate Design To Provide Biotinidase Stability by Wilbur, D. Scott, Hamlin, Donald K, Chyan, Ming-Kuan, Kegley, Brian B, Pathare, Pradip M

“…An investigation was conducted in which the stabilities of four structurally different biotin derivatives were assessed with regard to biotinamide bond…”
Get full text

Cobalamin analogues modulate the growth of leukemia cells in vitro by MCLEAN, G. R, PATHARE, P. M, WILBUR, D. S, MORGAN, A. C, WOODHOUSE, C. S, SCHRADER, J. W, ZILTENER, H. J

“…Analogues of cyanocobalamin (CN-Cbl), with functional groups attached to either the various propionamide groups of the corrin ring or to the ribose-nucleotide…”
Get full text

Biotin Reagents for Antibody Pretargeting. 3. Synthesis, Radioiodination, and Evaluation of Biotinylated Starburst Dendrimers by Wilbur, D. Scott, Pathare, Pradip M, Hamlin, Donald K, Buhler, Kent R, Vessella, Robert L

“…We are investigating the hypothesis that biotin multimers can be used with streptavidin and monoclonal antibody conjugates in cancer pretargeting protocols to…”
Get full text

Synthesis and radiolabeling of a biotin-CHX-B chelate for Bi-213 by Pathare, P. M., Hamlin, D. K., Wilbur, D.S., Brechbiel, M. W., Bray, L. A.

“…The synthesis and radiolabeling of a biotin derivative which contains a chelating group (CHX‐B) for binding the α‐emitting radionuclide, 213Bi, is described…”
Get full text

Biotin Reagents for Antibody Pretargeting. 4. Selection of Biotin Conjugates for in Vivo Application Based on Their Dissociation Rate from Avidin and Streptavidin by Wilbur, D. Scott, Chyan, Ming-Kuan, Pathare, Pradip M, Hamlin, Donald K, Frownfelter, Milah B, Kegley, Brian B

“…An investigation was conducted to determine the affect of structural variation of biotin conjugates on their dissociation rates from Av and SAv. This…”
Get full text

Biotin Reagents for Antibody Pretargeting. Synthesis, Radioiodination, and in Vitro Evaluation of Water Soluble, Biotinidase Resistant Biotin Derivatives by Wilbur, D. Scott, Hamlin, Donald K., Pathare, Pradip M., Weerawarna, S. Ananda

“…As part of our development of antibody pretargeting for cancer therapy, an investigation has been conducted to examine the stability of water solubilized,…”
Get full text

Synthesis of Cobalamin−Biotin Conjugates That Vary in the Position of Cobalamin Coupling. Evaluation of Cobalamin Derivative Binding to Transcobalamin II by Pathare, Pradip M, Wilbur, D. Scott, Heusser, Shannon, Quadros, Edward V, McLoughlin, Patricia, Morgan, A. Charles

“…Six cobalamin−biotin conjugates have been prepared. The cobalamin−biotin conjugates were prepared to evaluate the effect that the location of attachment had on…”
Get full text

Antibody Fragments in Tumor Pretargeting. Evaluation of Biotinylated Fab‘ Colocalization with Recombinant Streptavidin and Avidin by Wilbur, D. Scott, Hamlin, Donald K, Vessella, Robert L, Stray, James E, Buhler, Kent R, Stayton, Patrick S, Klumb, Lisa A, Pathare, Pradip M, Weerawarna, S. Ananda

“…An evaluation of the use of a biotinylated monoclonal antibody Fab‘ fragment in tumor pretargeting was conducted. As a model system, tumor colocalization of…”
Get full text

Biotin Reagents for Antibody Pretargeting. 2. Synthesis and in Vitro Evaluation of Biotin Dimers and Trimers for Cross-Linking of Streptavidin by Wilbur, D. Scott, Pathare, Pradip M, Hamlin, Donald K, Weerawarna, S. Ananda

“…Polymerization and/or cross-linking of recombinant streptavidin (r-SAv) with biotin derivatives containing two biotin moieties (biotin dimers) or three biotin…”
Get full text

Evaluation of Biotin−Dye Conjugates for Use in an HPLC Assay To Assess Relative Binding of Biotin Derivatives with Avidin and Streptavidin by Wilbur, D. Scott, Pathare, Pradip M, Hamlin, Donald K, Frownfelter, Milah B, Kegley, Brian B, Leung, Wai-Yee, Gee, Kyle R

“…In this investigation, studies were conducted to determine if size exclusion HPLC could be used to assess relative association rates (on-rates) and…”
Get full text

Streptavidin in Antibody Pretargeting. 2. Evaluation of Methods for Decreasing Localization of Streptavidin to Kidney while Retaining Its Tumor Binding Capacity by Wilbur, D. Scott, Hamlin, Donald K, Buhler, Kent R, Pathare, Pradip M, Vessella, Robert L, Stayton, Patrick S, To, Richard

“…An investigation has been conducted to determine if the kidney localization of recombinant streptavidin can be decreased to improve its characteristics in…”
Get full text

Radioiodination of Cyanocobalamin Conjugates Containing Hydrophilic Linkers: Preparation of a Radioiodinated Cyanocobalamin Monomer and Two Dimers, and Assessment of Their Binding with Transcobalamin II by Wilbur, D. Scott, Pathare, Pradip M, Hamlin, Donald K, Rothenberg, Sheldon P, Quadros, Edward V

“…This report describes an investigation aimed at preparation of radioiodinated cyanocobalamin (CN-Cbl) monomers and dimers with improved water solubility and…”
Get full text

Synthesis of Cobalamin Dimers Using Isophthalate Cross-Linking of Corrin Ring Carboxylates and Evaluation of Their Binding to Transcobalamin II by Pathare, Pradip M, Wilbur, D. Scott, Hamlin, Donald K, Heusser, Shannon, Quadros, Edward V, McLoughlin, Patricia, Morgan, A. Charles

“…Several cobalamin (Cbl) dimers have been prepared for evaluation as potential antiproliferative agents in the treatment of AIDS-related lymphoma. The Cbl…”
Get full text

Synthesis and nca-Radioiodination of Arylstannyl−Cobalamin Conjugates. Evaluation of Aryliodo−Cobalamin Conjugate Binding to Transcobalamin II and Biodistribution in Mice by Wilbur, D. Scott, Hamlin, Donald K, Pathare, Pradip M, Heusser, Shannon, Vessella, Robert L, Buhler, Kent R, Stray, James E, Daniel, Janna, Quadros, Edward V, McLoughlin, Patricia, Morgan, A. Charles

“…A new method of preparing radiolabeled cobalamin derivatives has been developed. The method involves the use of cobalamin−tri-n-butylstannyl hippurate…”
Get full text

Is adjuvant systemic therapy necessary for all axillary node negative breast cancer patients? by Pathare, P M, Peschel, R E

“…One hundred eighty-six breast cancer patients with either T1 or T2 primary tumors and negative axillary lymph nodes (N-) underwent only local therapy at…”
Get more information

SYNTHESIS OF PYRANOBENZOXAZINES AND 2-CHLOROMETHYLPYRANOBENZOXAZOLES by MERCHANT, J. R., PATHARE, P. M., SHINDE, N. M.

Get full text

SYNTHESIS AND PHYSIOLOGICAL ACTIVITY OF SOME NEW PYRANOBENZOXAZOLES by MERCHANT, J. R., SHINDE, N. M., PATHARE, P. M.

Get full text

Development of new biotin/streptavidin reagents for pretargeting by Scott Wilbur, D, Pathare, Pradip M, Hamlin, Donald K, Stayton, Patrick S, To, Richard, Klumb, Lisa A, Buhler, Kent R, Vessella, Robert L

“…The high affinity of biotin for streptavidin has made this pair of molecules very useful for in vivo applications. To optimize reagents for one potential in…”
Get full text

Reagents for Astatination of Biomolecules:  Comparison of the in Vivo Distribution and Stability of Some Radioiodinated/Astatinated Benzamidyl and nido-Carboranyl Compounds by Wilbur, D. Scott, Chyan, Ming-Kuan, Hamlin, Donald K, Kegley, Brian B, Risler, Reudi, Pathare, Pradip M, Quinn, Janna, Vessella, Robert L, Foulon, Catherine, Zalutsky, Michael, Wedge, Timothy J, Hawthorne, M. Frederick

“…An investigation has been conducted to assess the in vivo stability of a series of astatinated benzamides and astatinated nido-carborane compounds in mice. It…”
Get full text